Navigation Links
MET protein levels show promise as biomarker for aggressive colon cancer
Date:6/4/2013

HOUSTON - MET protein levels correlate strongly with epithelial-mesenchymal transition (EMT) phenotype, a treatment-resistant type of colorectal cancer and may be used as a surrogate biomarker, according to new research from The University of Texas MD Anderson Cancer Center.

The study results, which compared MET protein expression with protein/gene expression of EMT markers and evaluated impact on survival, were released today at the annual meeting of the American Society of Clinical Oncology.

"When the epithelial cells that line the colon become cancerous, some of them develop special features to allow migration, causing the cancer to be more aggressive," said Kanwal Pratap Singh Raghav, M.D., fellow in MD Anderson's Division of Cancer Medicine. "Although EMT is a dominant molecular subtype, a biomarker suitable for clinical use has not been found. This research gives us an important step toward learning more about treating this colorectal cancer subtype."

In a bigger picture view, the study provides another piece of the puzzle of personalized cancer diagnosis and treatment.

"While we know there are many of types of colorectal cancer, we're not as advanced as we'd like to be in our understanding of them," said Scott Kopetz, M.D., Ph.D., associate professor in MD Anderson's Department of Gastrointestinal Medical Oncology and senior author of the study. "One of the larger goals of our research is to classify simple biomarkers that can be used by doctors in the community to identify subtypes. We want to condense sophisticated gene signatures down to single markers and simple tests that can be used to guide therapy."

The data were tested with:

  • Mann-Whitney U-test and Spearman rank correlation to determine association between MET protein expression and protein/gene expression of EMT markers and EMT gene signature scores
  • Regression tree method and Kaplan-Meier estimates to assess overall survival

Results of the analysis showed higher MET levels were found more often in colon tumors than rectal tumors.

Overexpression of MET was associated with:

  • Decreased overall survival
  • Higher gene expression of 28 EMT markers
  • Higher gene scores derived from three published EMT gene signatures

The researchers also determined that MET protein expression did not correlate with MET gene expression.

Next steps

Going forward, the group plans to apply this approach to other colorectal cancer subtypes, hopefully defining other simple and readily available biomarkers.

"The ultimate success in targeting colorectal cancer requires understanding molecular subsets of the disease," Kopetz said. "If we can identify and group cancers with similar behaviors, we'll be closer to identifying vulnerabilities and optimal therapies for each subset."


'/>"/>

Contact: Laura Sussman
sussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Researchers gain insight into key protein linked to cancers, neurodegenerative disorders
2. Advancement in Biologic Protein Expression Webinar Hosted by Selexis SA
3. German and Israeli scientists gain new insights into protein disposal
4. Proteins in migration
5. Preclinical tests shows agent stops slippery proteins from binding, causing Ewing sarcoma
6. Study IDs key protein for cell death
7. Tumor-activated protein promotes cancer spread
8. Cancer drug prevents build-up of toxic brain protein
9. Amplification of a Stat5 gene produces excess oncogenic protein that drives prostate cancer spread
10. Can High-Protein, Low-Carb Diet Boost Fertility Treatment?
11. Assembly of a protein degradation machine could lead to treatments in cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... 2017 , ... Anahata Ananda of Shamangelic Healing, Sedona ... announce her “Spring Rejuvenation in Sedona” personally tailored retreats. For those wanting an ... soul an excellent opportunity to come out of hibernation and do some inner ...
(Date:2/27/2017)... ... February 27, 2017 , ... This ... diffraction analysis as a tool to characterize particle size distributions in the field ... improved results and novel scientific findings. It describes methods of optimized and standardized ...
(Date:2/27/2017)... ... 27, 2017 , ... Silicon Valley Hair Institute, a professional ... informational post on robotic hair transplantation. San Francisco residents may be confused over ... Unit Transplantation (FUT) can sound similar. Either treatment can be used to provide ...
(Date:2/26/2017)... ... February 26, 2017 , ... This is an extension of ... to be ISO/IEC 17025:2005 INAB accredited for Der p 1 (house dust mite ... globally recognised standard that sets out requirements for the technical competence of testing ...
(Date:2/26/2017)... ... ... ODH, Inc.™ announced today it will exhibit and speak at the ... in Arlington, VA. ODH’s director of medical strategy, Candace Saldarini, M.D., will present on ... health management. , ODH will also have an exhibit booth where attendees may speak ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Mass. , Feb. 24, 2017  Today, ... US dental labs have a new path to ... using the Biodenta implant library integrated into exocad ... must implement FDA compliant Good Manufacturing Processes (GMP,s) ... manufacturer with Biodenta, and complete an audit process. Then, ...
(Date:2/24/2017)... Feb 24, 2017 Research and Markets has announced ... 2016" report to their offering. ... The latest research Hemophilia Drugs Price Analysis and Strategies - ... The research answers the following questions: ... How are they positioned in the Global Hemophilia market? ...
(Date:2/24/2017)... 24, 2017 Juan Monteverde , founder ... , a boutique securities firm headquartered at the Empire ... , announces that a class action lawsuit has been ...  against Inotek Pharmaceuticals Corporation (NASDAQ:  ITEK)("Inotek" or the ... July 23, 2015 and December 30, 2016, inclusive (the ...
Breaking Medicine Technology: