Navigation Links
MEMS thermal sensor detects pre-atherosclerotic lesions
Date:3/7/2011

New York / Heidelberg, 7 March 2011 A new study published in the Annals of Biomedical Engineering shows that a MEMS thermal sensor deployed by an angiogram catheter can detect the earliest stages of atherosclerosis. The MEMS thermal sensor used convective heat transfer to detect pre-atherosclerotic regions of arteries that otherwise showed no clinical signs of atherosclerosis.

Although diet and lifestyle changes can often reverse atherosclerosis in its earliest stages, no real-time means of detecting pre-atherosclerotic regions exists. The MEMS sensor method has the advantage of being both minimally invasive and sensitive. The technology has the potential for widespread and rapid application during diagnostic angiograms.

The study's lead author, Dr. Tzung Hsiai, an Associate Professor of Biomedical Engineering and Cardiology at the University of Southern California, said, "The innovation of this study lies in the convective heat transfer strategy to detect changes in output voltage signals in the non-obstructive, albeit inflammatory and otherwise considered normal arterial regions."

Scientists have demonstrated that frictional force acting on the walls of vessels by blood flow, known as shear stress, is intimately involved in oxidative stress and inflammatory responses that lead to atherosclerosis. In athero-prone regions, the flow is disturbed, yet detection of changing flow patterns in real-time remains a challenge.

Dr. Hsiai's group developed a micro-electro-mechanical system (MEMS) by depositing titanium and platinum on a flexible polymer membrane and patterning them to form the sensing elements. They deployed the sensor via an angiogram catheter into the aortic and abdominal arteries of rabbits that had eaten a high fat, high cholesterol diet, and a control group that had eaten a normal diet.

An electric current passed through the sensing element and generated a thermal layer in the flow field, from which convective heat transfer was measured as a function of the voltage signals. In the regions of atherosclerotic lesions, blood flow is disturbed. This causes changes in convective heat transfer from the sensing element to the flow field, and thus, changes in voltage signals. The sensor measured a high voltage upstream from the part of the blood vessel that harbored the atherosclerotic plaque, and a low voltage downstream.

The scientists concluded that the MEMS thermal sensor method could sensitively detect pre-atherosclerotic regions that otherwise showed no clinical signs of atherosclerosis. The authors integrated mathematical simulations, fluoroscopic images, and dissection of the aortas to verify their results.

Once the MEMS thermal sensors have identified the atherosclerotic lesion, doctors can identify whether this lesion is a vulnerable or stable plaque. A vulnerable plaque could rupture, which blocks the arteries and causes heart attacks and strokes. Doctors perform angioplasty and implant stents to prevent blockage of vessels. However, lifestyle changes and medication can manage stable plaque.

According to Dr. Hsiai, "Despite imaging modalities, we have yet to develop a means to differentiate vulnerable from stable plaque. If we can differentiate vulnerable from stable plaque during a diagnostic angiogram, we can avoid unnecessary complications from angioplasty and stenting, and deliver an enhanced risk-to-benefit profile for our patients. It could also reduce health costs by eliminating unnecessary procedures and for treating procedure-related complications."


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Case Western Reserve University grants Thermalin Diabetes exclusive license
2. Implantable Sensor Measures Blood Sugar Levels
3. Insulin Pump With Blood Sugar Sensor May Improve on Injections
4. Sensor and insulin pump results in better blood-sugar control in all age groups with diabetes
5. New method manipulates particles for sensors, crime scene testing
6. Nanotech breath sensor detects diabetes and potentially serious complication
7. Long-lasting sensory loss in WTC workers
8. Loadstar Sensors Releases LoadVUE-1000 Load Cell Software with Logging, Plotting and Alerting features
9. Biosensor chip enables high-sensitivity protein analysis for disease diagnosis
10. Loadstar Sensors Announces New Website for its Innovative Digital Load Cell Solutions
11. Immune sensors suppress colitis-associated cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite ... program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017 West Pharmaceutical Services, Inc. ... for injectable drug administration, today announced that it will ... on Thursday, October 26, 2017, and will follow with ... expectations at 9:00 a.m. Eastern Time. To participate on ... The conference ID is 94093362. ...
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
Breaking Medicine Technology: