Navigation Links
MEK4, genistein and invasion of human prostate cancer cells
Date:7/28/2009

Researchers have identified MEK4 as a pro-invasion protein and the target for genistein, a dietary compound, in prostate cancer cells, according to a new study published online July 28 in the Journal of the National Cancer Institute.

Li Xu, M.D., Ph.D., and Raymond C. Bergan, M.D., of the Department of Medicine at Northwestern University in Chicago, and colleagues investigated the target for genistein in prostate cancer cells by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and matrix metalloproteinase-2 (MMP-2), which is associated with cell invasion.

Overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically significantly higher in normal prostate epithelial cells, which are target cells for chemoprevention, from untreated patients with prostate cancer than from genistein-treated patients.

"Thus, we have shown that it is possible to target motility-associated processes with genistein in patients with prostate cancer, have identified MEK4 as the therapeutic target for genistein in all six prostate cell lines examined, and have provided a possible mechanism to link high dietary consumption of genistein-containing foods with lower rates of prostate cancer metastasis and mortality," the authors write.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. A new weapon for attacking tumor invasion and metastasis
2. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
3. Consumer Advocate Speaks Out Against Bill Allowing Invasions of Medical Privacy; Author Received $21k from Bill Benefactors
4. Consumer Advocate to Testify Against Bill Allowing Invasions of Medical Privacy
5. Humanitas Designated as Approved Provider by California Board of Registered Nursing for Continuing Education Course Credit and Units
6. Itanium Solutions Alliance Selects Swedens Kiwok as the 2009 Innovation Awards Winner for Humanitarian Impact
7. Ozen Engineering Inc. donates human body-modeling software to Clemson
8. Human Rights Campaign Announces Speakers at 25th Annual Bay Area Gala
9. Human cells secrete cancer-killing protein, UK study finds
10. Human Genome Sciences Announces Second-Quarter 2009 Financial Results and Key Developments
11. Vaxine Wins Line Honours With Worlds First Human Swine Flu Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and ... explains one of the most popular and least understood books in the Holy Scriptures, ... puzzling descriptions that have baffled scholars for centuries. Many have tossed it off as ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
Breaking Medicine Technology: