Navigation Links
MEK4, genistein and invasion of human prostate cancer cells
Date:7/28/2009

Researchers have identified MEK4 as a pro-invasion protein and the target for genistein, a dietary compound, in prostate cancer cells, according to a new study published online July 28 in the Journal of the National Cancer Institute.

Li Xu, M.D., Ph.D., and Raymond C. Bergan, M.D., of the Department of Medicine at Northwestern University in Chicago, and colleagues investigated the target for genistein in prostate cancer cells by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and matrix metalloproteinase-2 (MMP-2), which is associated with cell invasion.

Overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed that genistein could bind to the active site of MEK4, and an enzymatic assay showed that genistein inhibited MEK4 kinase activity. The MMP-2 transcript level was statistically significantly higher in normal prostate epithelial cells, which are target cells for chemoprevention, from untreated patients with prostate cancer than from genistein-treated patients.

"Thus, we have shown that it is possible to target motility-associated processes with genistein in patients with prostate cancer, have identified MEK4 as the therapeutic target for genistein in all six prostate cell lines examined, and have provided a possible mechanism to link high dietary consumption of genistein-containing foods with lower rates of prostate cancer metastasis and mortality," the authors write.


'/>"/>

Contact: Steve Graff
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. A new weapon for attacking tumor invasion and metastasis
2. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
3. Consumer Advocate Speaks Out Against Bill Allowing Invasions of Medical Privacy; Author Received $21k from Bill Benefactors
4. Consumer Advocate to Testify Against Bill Allowing Invasions of Medical Privacy
5. Humanitas Designated as Approved Provider by California Board of Registered Nursing for Continuing Education Course Credit and Units
6. Itanium Solutions Alliance Selects Swedens Kiwok as the 2009 Innovation Awards Winner for Humanitarian Impact
7. Ozen Engineering Inc. donates human body-modeling software to Clemson
8. Human Rights Campaign Announces Speakers at 25th Annual Bay Area Gala
9. Human cells secrete cancer-killing protein, UK study finds
10. Human Genome Sciences Announces Second-Quarter 2009 Financial Results and Key Developments
11. Vaxine Wins Line Honours With Worlds First Human Swine Flu Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... been awarded a three-year $1.7 million grant from ... new imaging technologies and data analysis techniques that ... of neurons in the brain interact to process ... the precise interactions between millions of nerve cells ... alterations in these interactions that may be responsible ...
(Date:9/30/2014)... EverStryke , the permanent match currently offered by ... a free book and class all about survival education and ... investigative review. , “Joe Marshall of SurvivalLife.com is one ... niche, and this product is an excellent way to get ... that Joe offers on his website to help people be ...
(Date:9/30/2014)... Elevate , the latest product from Blue Start ... of the gym by providing natural ingredients that boost brain ... Michaels, prompting an investigative review. , “When it comes ... simply just don’t have the ability to perform the way ... the motivation to finish a project, or even feeling like ...
(Date:9/30/2014)... Los Angeles, CA (PRWEB) September 30, 2014 ... plastic surgery providers in Turkey has gone up more ... of growth. The medical tourism company also reported total ... since October 2012. , The company’s professional strategy has ... in Turkey — ultimately designed for patient comfort and ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Hospice ... its annual “In Celebration” gala, honoring three outstanding ... mission of striving to provide extraordinary and dignified ... facing a serious or life-limiting illness. , The ... in Rye, NY and recognized William (Bill) J. ...
Breaking Medicine News(10 mins):Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:EverStryke: Review Exposes Joe Marshall’s Permanent Match Survival Product 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 2Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 3Health News:VisitandCare.com Announces Record Demand for Plastic Surgery in Turkey 4Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2
... Calif., July 1 Everock, Inc. (Pink Sheets: EVRN) announced ... privately held Nature,s Peak, Inc. whereby its business assets and ... Peak has assumed control of the newly combined company and, ... reflect this. Paul Wilkinson, founder and CEO of Nature,s Peak ...
... ... recognized by PRSA with a Bronze Anvil for its media relations efforts for Catholic Healthcare ... ... and new media agency, has been recognized by PRSA with a Bronze Anvil for its ...
... YORK, July 1 The Nielsen Company , ... one of the world,s most recognized international advertising and design competitions, ... is now accepting online entry submissions at www.CLIOHealthcare.com ... work appearing between January 1, 2008 and June 30, 2009. , ...
... fifth graders and their younger siblings, recently received $1.45 ... part of the National Institutes of Health,s American Recovery ... years. The program aims to enhance the quality ... behavior and use of drugs among youth as they ...
... Veterinarians for Dedication to Improving Animal Health and Well-Being ... veterinarian for the third annual Thank Your Vet for ... (MAF). The national short-essay contest honors America,s veterinarians for ... we have with our pets. The nationwide essay contest ...
... prevent disease, lower health care costs , , ... organizations in health care, science, medicine and public health ... goal in mind: to develop a national physical activity ... members of the public both agree that emphasizing disease ...
Cached Medicine News:Health News:Everock, Inc. Completes Reverse Merger with Privately Held All-Natural Food Producer, Nature's Peak 2Health News:Everock, Inc. Completes Reverse Merger with Privately Held All-Natural Food Producer, Nature's Peak 3Health News:Tempe-Based Marketing Agency Receives Prestigious National Healthcare Marketing Award, Several Regional Awards 2Health News:Tempe-Based Marketing Agency Receives Prestigious National Healthcare Marketing Award, Several Regional Awards 3Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 2Health News:Nielsen Announces First-Ever CLIO Healthcare Awards Now Accepting Entries 3Health News:Search for America's Best Veterinarian Continues With Third Annual 'Thank Your Vet for a Healthy Pet(R)' Contest 2Health News:Policymakers, Experts, Public Agree: Physical Activity Plan Needed 2Health News:Policymakers, Experts, Public Agree: Physical Activity Plan Needed 3
(Date:9/30/2014)... 2014 Arbor Pharmaceuticals, LLC. - Product ... Markets Direct,s, ,Arbor Pharmaceuticals, LLC. - Product Pipeline ... Arbor Pharmaceuticals, LLC.,s pharmaceutical research and development focus. ... current therapeutic developmental pipeline of Arbor Pharmaceuticals, LLC.,s, ... assessment by drug target, mechanism of action (MoA), ...
(Date:9/30/2014)... Sept. 30, 2014  According to their CEO, ... cancer clinical trials is going through a complete ... the work of the current clinical trial management ... ,next generation, clinical trials, which will ultimately drive ... The company has been recognized by the ...
(Date:9/30/2014)... A study using a relatively new imaging ... at the composition of carotid artery disease and has ... the disease, a leading cause of stroke. ... September 2010 and May 2012, was featured in the ... American College of Cardiology (JACC) Cardiovascular Interventions. Interventional ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2New Imaging Tool May Allow Tailoring of Stroke Prevention to Each Patient 2
Tying forceps with 6.5 mm tying platform. Round handle with flats provide flexibility of round handle with the stability of a flat handle. Curved shafts. Overall length 3.9 inches....
Delicate curved tying forcep with round handle is excellent for all fine suturing techniques. Useful for corneal transplants where delicate control is required....
Straight, 7 mm tying platform. Castroviejo handle. Manufactured in titanium. Overall length 4.2 inches....
Straight 6 mm platform. McPherson handle. Manufactured in titanium. Overall length 3.3 inches....
Medicine Products: