Navigation Links
MDC researchers: Ion channel makes African naked mole-rat insensitive to acid-induced pain
Date:12/20/2011

inflammatory joint diseases such as rheumatism contains high concentrations of acid. These high acid levels in the tissue activate the pain sensors.

Naked mole-rats also have pain sensors. In a previous study, the research group of Professor Lewin already showed that naked mole-rats are just as sensitive to heat and pressure as mice are. In contrast, they do not feel any pain when they are exposed to acid. Moreover, as Dr. St. John Smith and Professor Lewin report in the American journal Science, naked mole-rats also have the Nav1.7 ion channel like other mammals, including mice and humans. The researchers therefore investigated the function of this ion channel in naked mole-rat and in mouse sensory nerves to determine whether there is a difference between the two species in the function of this ion channel.

In the present study the researchers showed that the NaV1.7 ion channel of the naked mole-rat does in fact differ in structure from that of the mouse or of humans. Ion channels are proteins composed of amino acids, the blueprint of which is coded by the genes. In the NaV1.7 ion channel of the naked mole-rat, three amino acid building blocks are different from those in all other mammals. These three altered protein subunits lead to profound impairment or blockage of the naked mole-rat ion channel by acid. This phenomenon can also be observed in the Nav1.7 ion channel of mice and humans, but it is so weak that the transmission of pain signals is hardly disturbed.

In the naked mole-rat, however, this mutated ion channel is sufficient to inhibit signal transduction. The reason for the mutation in the ion channel, according to the researchers, is that naked mole-rats have adapted over the course of evolution to the high CO2 levels in the air and thus have become insensitive to pain induced by acid. This is also the case when in the nerve cells of the naked mole-rats other ion channels are activated by acid stimuli that would normal
'/>"/>

Contact: bachtler@mdc-berlin.de
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IU researchers: Chemotherapy alters brain tissue in breast cancer patients
2. Ben-Gurion U. researchers: High resistance rates among acute otitis media pathogens in children
3. Researchers: Pay more attention to epilepsy
4. Researchers: Elderly patients 4 times more likely to die from treatment complications
5. Researchers: Sexually active teens need confidential health care
6. Wistar researchers: Direct proof of how T cells stay in standby mode
7. Mayo researchers: Genetic mutation linked to Parkinsons disease
8. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
9. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
10. 29 Clear Channel stations Nationwide Raise Nearly $2.8 Million to Help Save the Lives of Kids Fighting Cancer and Other Deadly Diseases
11. Lakeside Medical Group, Heritage Provider Network, CEO Dr. Richard Merkin, Featured on Several Segments of Fox National News and Fox Business Channel on Current Healthcare Payment Structures to Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... A January 2013 study published ... in those who were self-diagnosed gluten-intolerant yielded little verifiable ... for San Diego health and wellness retreat VeraVia ... those who are unclear about the role gluten plays ... a protein, found in wheat, barley, rye, and triticale. ...
(Date:7/28/2014)... HealthDay Reporter MONDAY, July ... just milliseconds to look at someone,s face and judge them ... that certain facial features seem to trigger specific first impressions ... of the mouth, for example, appear directly linked to whether ... The study findings suggest that first impressions are ...
(Date:7/28/2014)... 28, 2014 Shofner Vision Center ... June . Renowned LASIK and Cataract Surgeon, Dr. ... significant funds and public awareness for local not-for-profit ... personnel and their families. “This was our 2nd ... nearly $5,000 to a variety of local not-for-profit ...
(Date:7/28/2014)... 2014 (HealthDay News) --,The more chronic medical conditions people ... may be, a new study claims. Since ... issues, scientists at Johns Hopkins Bloomberg School of Public ... why gains in life expectancy are slowing in the ... as diabetes, kidney disease and heart failure is now ...
(Date:7/28/2014)... SIMpalm helped its client to launch ... on iTunes for download . Experience a new way ... you to listen and cook along with expert real-time audio ... out the ingredients and equipment, press play, and follow the ... ahead of time, just relax and cook along with us. ...
Breaking Medicine News(10 mins):Health News:VeraVia Explains the Basics of Gluten-Intolerance Following Industry Study 2Health News:VeraVia Explains the Basics of Gluten-Intolerance Following Industry Study 3Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4
... Calif., July 9 Exponent, Inc.,(Nasdaq: EXPO ), ... second quarter ended June 27, 2008, immediately following the ... Company will host a,corresponding conference call and live webcast ... Gaulke, Chairman and Chief Executive,Officer, and Richard Schlenker, Chief ...
... That Protect Patient Access To Community,Pharmacies, ... Senate,today voted by unanimous consent in favor ... and Providers Act of 2008 contains three ... Part D claims, delayed cuts to Medicaid ...
... Infection toll at 1,017; health officials add hot peppers ... WEDNESDAY, July 9 (HealthDay News) -- The number of ... surpassed 1,000, and while certain types of tomatoes remain ... hot peppers and cilantro as potential suspects. , ...
... doesn,t improve death rates, study finds , , WEDNESDAY, July ... of patients whose lungs fill with water because of ... a new British study shows. , The study found ... -- continuous positive airway pressure (CPAP) and noninvasive intermittent ...
... CEO of the American,Association for Homecare, ARLINGTON, ... providers are just as appalled as lawmakers and,Medicare ... identification,numbers from deceased doctors to bilk millions of ... and manufacturers represented by,the American Association for Homecare ...
... The #1 Safety Hazard in Most Hospitals, WASHINGTON, July ... at CHRISTUS Spohn Health System (Corpus Christi TX),received overdoses of ... CDT,one of the babies has died; another is in critical ... why computerized systems for,ordering medication in hospitals has been The ...
Cached Medicine News:Health News:Salmonella Illnesses Now Top 1,000 2Health News:Salmonella Illnesses Now Top 1,000 3Health News:Assisted Breathing Eases Lung Symptoms for Heart Patients 2Health News:Home Medical Equipment Providers Are Appalled by 'Dead-Doctor' Scam, Strongly Support Anti-Fraud Efforts to Protect Medicare System 2Health News:Home Medical Equipment Providers Are Appalled by 'Dead-Doctor' Scam, Strongly Support Anti-Fraud Efforts to Protect Medicare System 3Health News:Statement of the Leapfrog Group on Hospital Overdose of Up to 17 Babies at CHRISTUS Spohn 2
(Date:7/28/2014)... -- Concord Medical Services Holdings Limited ("Concord Medical" or ... specialty hospital management solution provider and operator of the ... China , today announced that on ... special cash dividend of US$0.30 per ordinary share (or ... outstanding ordinary shares. The total expense for the special ...
(Date:7/28/2014)... July 28, 2014 ... 2,5 Millionen £ investiert hat, um die ... Gesundheits-, Pharma- und Logistikbranche zu erfüllen. Albion ...      (Photo: http://photos.prnewswire.com/prnh/20140728/697982 ) ... OmPrompt sein beschleunigtes Wachstum mit Investitionen in ...
(Date:7/28/2014)... MURRAY HILL and NEW PROVIDENCE, ... management and engineering professionals are invited to meet with ... Conference and Technical Exhibition to be held at McCormick ... August 3-6. "Hospitals demand nothing less ... said Mark Sanda , Linde,s Healthcare Segment manager. ...
Breaking Medicine Technology:Concord Medical Declares Special Dividend 2OmPrompt erhält Finanzierung für Marktexpansion von Kundenautomatisierungsmanagement 2Linde's Healthcare division to display new Hospital Services platform at the national ASHE Conference in Chicago 2
... , DENVER , Jan. 28 Global ... Board: GLOB), an international healthcare information technology company, today announced ... management software and Donor Doc® health history questionnaire to Community ... Kansas City, Missouri . Terms of the agreement were ...
... , , MOUNTAIN VIEW, Calif. ... announced the initiation of a Phase I clinical trial ... autoimmune diseases.  CCX168 is a highly potent and very ... a component of the body,s complement system and a ...
Cached Medicine Technology:Global Med Technologies(R)' Solution of Choice for Important Regional Blood Center 2Global Med Technologies(R)' Solution of Choice for Important Regional Blood Center 3Global Med Technologies(R)' Solution of Choice for Important Regional Blood Center 4Global Med Technologies(R)' Solution of Choice for Important Regional Blood Center 5ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 2ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 3ChemoCentryx Initiates Clinical Trial of CCX168, A Novel Small Molecule C5aR Antagonist for the Treatment of Inflammatory and Autoimmune Diseases 4
PremierEdge Stab Knives - 15....
DCR Set, Straight....
... acknowledged to be the easiest to use, ... benefits are due to the exclusive use ... footprint available coupled with advanced electronics and ... reading. Thus corneal thickness measurements can be ...
... The Leica CM1850 cryostat for ... histopathology laboratory is designed for ... workload. A new insulation technology ... the refrigerating system and maintains ...
Medicine Products: