Navigation Links
MD Anderson researcher uncovers some of the ancient mysteries of leprosy
Date:2/20/2014

leprosy bacteria's pseudogenes suggest that gene inactivation began approximately 20 million years ago. This is likely the point when the ancestor of leprosy bacteria jumped to our early human ancestors and transitioned from free-living to strictly parasitic. In essence, the theory unifies the reductive evolution of the leprosy bacteria and their strict parasitic lifestyle in humans into a single continuous, long process.

Insights into the pathogenesis of leprosy

Han and Silva also brought human evolution, host genetic diversity, and host immunity into the complex picture of leprosy. Their hypothesis that leprosy existed for millions of years offers new insights into disease pathogenesis.

For example, the parasitic adaptation of the leprosy bacteria inside hominid-human hosts is similar to a very long hide-and-seek game. In this scenario, the parasite hides by mutating or removing harmful molecules while retaining protective ones. In the end, this leads to evasion from host immunity, a phenomenon commonly seen in leprosy. Finally, Han and Silva concluded that leprosy can be viewed as a natural consequence of a long parasitism.

Han, a clinical microbiologist, routinely diagnoses secondary infections caused by various kinds of microbes in patients with cancer. "Many patients who come to MD Anderson suspected of having cancer turn out to have infections instead and we make such game-changing diagnoses nearly every day" said Dr. Han.

"Discovering the new leprosy agent Mycobacterium lepromatosis was incidental. However, locating this additional leprosy cause significantly adds to our understanding of the ancient disease. In particular, tracing the ultimate origin of leprosy through the parasitic adaptive evolution of the leprosy bacteria is rather insightful, not only for this single disease but also for our better understanding of the mechanism behind other human infections. Medical historians and anthropologist
'/>"/>

Contact: Jim Newman
jnewman@mdanderson.org
713-792-0664
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. UT MD Anderson study finds cancer related pain often undertreated
2. University of Houston Graduate College of Social Work announces partnership with MD Anderson
3. UT MD Anderson President Ronald DePinho elected to National Academy of Sciences
4. UT MD Anderson study finds link between depressive symptoms and cancer survival
5. UT MD Anderson Cancer Center launches unprecedented Moon Shots Program
6. UT MD Anderson study finds link between statins and improved survival in inflammatory breast cancer
7. Horner Flooring to provide court for the MD Anderson Proton Therapy Showcase in Houston.
8. UT MD Anderson, GlaxoSmithKline to collaborate on new approach to cancer immune therapy
9. UT MD Anderson scientists find protein that reins in runaway network
10. MD Anderson study finds qigong improves quality of life for breast cancer patients
11. Leading National Law Firm Anderson Kill & Olick Concludes NRRA Not Intended to Apply to Captive Insurance Companies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... retrospective study led by researchers at Brigham and ... colonoscopies for colorectal cancer screening and surveillance. The ... intervals than established guidelines support, and these recommendations ... , "Our study shows that a high percentage ... resulting in use of scarce health care resources ...
(Date:9/29/2014)... Atlantic NeuroSurgical Specialists (ANS) brain ... to celebrate their strides in their fight against brain cancer. ... at their Morristown office. , The annual BBQ has grown ... a place where patients can find love, hope and support ... and activities were enjoyed by guests, including a dunk tank ...
(Date:9/29/2014)... September 30, 2014 NAPW ... as a 2014 Professional Woman of the Year. Ms. ... in home healthcare. As the largest networking organization of ... and profession, the National Association of Professional Women is ... and nearly 300 Local Chapters. , “I love the ...
(Date:9/29/2014)... NY (PRWEB) September 30, 2014 ... B.S.N., Clinical Manager Specialist, as a 2014 Professional Woman ... prestigious distinction for leadership in clinical care. As the ... spanning virtually every industry and profession, the National Association ... with over 600,000 members and nearly 300 Local Chapters. ...
(Date:9/29/2014)... September 30, 2014 Top10BestSEOHosting.com is ... reviews about hosting products. It is headed by ... experience. The site offers research-based information and factual ... suppliers in the current market. , Top10BestSEOHosting.com ... announced that GoDaddy ( http://www.top10bestseohosting.com/go/GoDaddy.com/ ) and Bluehost ...
Breaking Medicine News(10 mins):Health News:Endoscopists recommend frequent colonoscopies, leading to its overuse 2Health News:Local Brain Tumor Foundation, ANS Center of Hope, Celebrates its Brain Cancer Patients 2Health News:National Association of Professional Women Announces Carol A. Stormer, Home Health Occupational at LHC GroupTherapist, a 2014 Professional Woman of the Year 2Health News:National Association of Professional Women Announces Sarah Shiermeister, Clinical Manager Specialist at Gentiva Health Services, a 2014 Professional Woman of the Year 2Health News:Top10BestSEOHosting.com: New Reviews for Linux Web Hosting Suppliers Available Online 2
... standard for grading, staging and "stad-ging" the chronic liver ... acquiring new knowledge on the liver pathology. Demand for ... in liver biopsy samples has been fuelled by the ... molecules on the lesions characterising the histological patterns of ...
... 31 /PRNewswire-Asia-FirstCall/ -- China Medical Technologies,Inc. (the ... leading China-based medical device,company that develops, manufactures ... that the Company has completed the previously,announced ... tumor therapy system,business (the "HIFU Business") to ...
... in Near Term Continue Trading Under the Ticker ... HAXS ) and BPO Management Services, Inc., ... focused on serving middle-market enterprises, today jointly announced ... the previously announced merger in which BPOMS will ...
... Dec. 30 Scantek Medical, Inc. (Pink ... it filed a voluntary petition in the United States ... of the United States Code. Scantek also announced ... BreastCare(TM)/BreastAlert(TM) Differential Temperature Sensor product ("BreastCare") to a medical ...
... CAMBRIDGE, Mass., Dec. 30 Biopure Corporation (Nasdaq: ... has advised the U.S. Naval Medical Research Center ("NMRC") by ... Biopure,s product Hemopure [hemoglobin glutamer - 250 (bovine)], under a ... As previously announced, the Navy had filed a protocol ...
... Dec. 30 Biopure Corporation (Nasdaq: BPUR ... The NASDAQ Stock Market stating that NASDAQ has again ... value requirements for continued listing, thereby extending the Company,s ... these rules is scheduled to resume on Monday, April ...
Cached Medicine News:Health News:A rigorous method for liver biopsy 2Health News:China Medical Technologies Announces the Completion of the Sale of its HIFU Business 2Health News:China Medical Technologies Announces the Completion of the Sale of its HIFU Business 3Health News:China Medical Technologies Announces the Completion of the Sale of its HIFU Business 4Health News:China Medical Technologies Announces the Completion of the Sale of its HIFU Business 5Health News:Healthaxis and BPO Management Services, Inc. Announce Closing of Merger 2Health News:Healthaxis and BPO Management Services, Inc. Announce Closing of Merger 3Health News:Scantek Medical Files for Chapter 11 Voluntary Bankruptcy and Receives Orders for the Sale of BreastCare(TM) 2Health News:U.S. Navy Requested Operations Trial on FDA Hold 2Health News:U.S. Navy Requested Operations Trial on FDA Hold 3Health News:Biopure Receives Extension of Time to Regain NASDAQ Listing Compliance 2
(Date:9/29/2014)... DUBLIN , Sept. 29, 2014 Research ... "Cardiac Pacemakers - Global Trends, Estimates and Forecasts, 2012-2018" ... sector is projected to reach US$5.7 billion by 2016. The ... global market share while Europe claims ... fastest growing region with a CAGR of 11.4% driving a ...
(Date:9/29/2014)... 2014  Guerbet, a pioneer in the field ... a Drug Shortage Assistance Award from the U.S. ... preventing or alleviating a drug shortage. ... to the shortage of Ethiodol (ethiodized oil) injection, ... post-approval supplements to restart manufacturing with acceptable compliance ...
(Date:9/29/2014)... , Sept. 29, 2014 Adaptive ... Next Generation Sequencing to profile the adaptive immune ... Scientific Advisory Board to provide strategic and clinical ... suite of assays in the diagnosis and monitoring ... focus of the SAB will be to support ...
Breaking Medicine Technology:Global Cardiac Pacemakers - Trends, Estimates and Forecasts to 2018 2Global Cardiac Pacemakers - Trends, Estimates and Forecasts to 2018 3Global Cardiac Pacemakers - Trends, Estimates and Forecasts to 2018 4Global Cardiac Pacemakers - Trends, Estimates and Forecasts to 2018 5Guerbet Receives FDA's Drug Shortage Assistance Award: Recognized for contributions to address a shortage of Ethiodol (ethiodized oil) injection 2Adaptive Biotechnologies Announces the Formation of a Hematologic Malignancies Scientific Advisory Board 2Adaptive Biotechnologies Announces the Formation of a Hematologic Malignancies Scientific Advisory Board 3
... Catalyst system introduces a new ... to microsurgical instrumentation. It has ... design with advanced microcomputer control ... to operate with a full ...
The Storz Premiere comes as anterior, posterior and anterior/posterior combo. The combo provides the following modes irrigation, irrigation/aspiration, vitrectomy, and illumination....
... Horizon Phacoemulsification System is ... surgical system. Lightweight and ... performance and features in ... also provides all modes ...
Compact ultrasonic phacoemulsification system....
Medicine Products: