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MD Anderson researcher uncovers some of the ancient mysteries of leprosy
Date:2/20/2014

Research at The University of Texas MD Anderson Cancer Center is finally unearthing some of the ancient mysteries behind leprosy, also known as Hansen's disease, which has plagued mankind throughout history. The new research findings appear in the current edition of journal PLOS Neglected Tropical Diseases. According to this new hypothesis, the disease might be the oldest human-specific infection, with roots that likely stem back millions of years.

There are hundreds of thousands of new cases of leprosy worldwide each year, but the disease is rare in the United States, with 100-200 new cases annually. Leprosy is known for attacking a patient's skin and nerves. Effective antimicrobial treatments exist today. However, when misdiagnosed or untreated, the disease can lead to extensive skin lesions, deformities in the patient's face and extremities, disabilities, and even death. Leprosy carries a social stigma and diagnosis is frequently and notoriously delayed.

An incidental yet important discovery

Work led by MD Anderson pathologist Xiang-Yang Han, M.D., Ph.D., a professor in laboratory medicine, resulted in the discovery in 2008 of a new leprosy-causing species, called Mycobacterium lepromatosis. Before that time, only one species of bacteria, called Mycobacterium leprae, was known to cause leprosy.

In the past several years, Han and other researchers have found the new leprosy agent in patients from Mexico, Canada, Brazil, Singapore, and Myanmar. Han's team, in collaboration with Francisco Silva, an evolutionary geneticist from Spain, analyzed 20 genes of Mycobacterium lepromatosis and compared them with those of Mycobacterium leprae.

They found the two leprosy bacteria came from a last common ancestor around 10 million years ago. Before the divergence, the common bacteria ancestor had undergone a massive reductive evolution that resulted in inactivation of approximately 40 percent of
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Contact: Jim Newman
jnewman@mdanderson.org
713-792-0664
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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