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MCG selected as RNA laboratory for worldwide diabetes study
Date:12/17/2007

e an early heads up that the body is headed toward diabetes.

These two different types of genetic material contain different information, Dr. She explains. The basic information of DNA does not change. What changes in DNA is how it may or may not allow expression of genes. RNA changes all the time.

Think about when you get the flu and your body starts to increase the number of immune cells to fight it, says Dr. Richard A. McIndoe, associate center director and co-principal investigator. That requires an expansion of your cells, which requires an expansion of proteins, which requires an expansion of RNA. Infection is an environmental trigger. Your RNA changed because you had an infection.

When you are getting diabetes, your RNA expression also changes, says Dr. She. Changes may or may not be permanent, but the goal is to connect the pieces and see which changes amount to type 1 diabetes, he says.

MCGs TEDDY Clinical Center is screening newborns in nine hospitals, including MCG Medical Center, University Hospital, Trinity Hospital of Augusta; Northside, Piedmont and Kennestone Hospitals in Atlanta; and three hospitals in Gainesville, Fla. Additional centers include Barbara Davis Center at the University of Colorado; Pacific Northwest Research Institute in Seattle; the University of Turku in Finland; Lund University in Sweden; and the Diabetes Research Institute in Munich, Germany. The University of South Florida in Tampa serves as the TEDDY data coordinating center and MCGs new contract with the NIDDK for nucleic acid isolation is through that university.

To date, MCGs center has enrolled about 500 children. An additional 800 to 1,000 enrollees in the next two-and-one-half years are planned.


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Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia  
Source:Eurekalert

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