Navigation Links
MCG selected as RNA laboratory for worldwide diabetes study

The Medical College of Georgia Center for Biotechnology and Genomic Medicine has been selected to isolate RNA and DNA from the blood of thousands of children involved in a worldwide study of the causes of type 1 diabetes.

MCG also is enrolling children in the mammoth study that will eventually follow 8,000 at-risk babies from four states and three countries for 15 years, collecting blood every three months as they go.

The TEDDY The Environmental Determinants of Diabetes in the Young study is keeping tabs on many aspects of the childrens lives from emergency room visits to over-the-counter medicines in an effort to identify environmental triggers for diabetes in children with known high-risk genes.

Once you know the risk factors, you can modulate the risk factors to prevent diabetes, says Dr. Jin-Xiong She, center director and Georgia Research Alliance Eminent Scholar in Genomic Medicine.

Dr. She was among the scientists who conceived the idea of TEDDY and successfully applied for National Institutes of Health funding to pursue it in 2003.

He recently was named principal investigator on the additional five-year, $5 million contract to isolate RNA and DNA from the regularly collected blood.

About 20,000 samples already are awaiting the process. The MCG Center developed a robotic automation that processes 96 samples in about two hours compared to the standard of a few samples in about six hours to handle the huge and growing volume.

Gene expression over time is a new area of research, says Dr. She. The newly established infrastructure enables MCG to isolate nucleic acids for similar large-scale studies.

Isolated nucleic acids will be stored at the National Institute of Diabetes and Digestive and Kidney Diseases Repository. TEDDY scientists will eventually analyze the impact of environmental triggers on the bodys basic building blocks with an eye toward identifying biomarkers that give an early heads up that the body is headed toward diabetes.

These two different types of genetic material contain different information, Dr. She explains. The basic information of DNA does not change. What changes in DNA is how it may or may not allow expression of genes. RNA changes all the time.

Think about when you get the flu and your body starts to increase the number of immune cells to fight it, says Dr. Richard A. McIndoe, associate center director and co-principal investigator. That requires an expansion of your cells, which requires an expansion of proteins, which requires an expansion of RNA. Infection is an environmental trigger. Your RNA changed because you had an infection.

When you are getting diabetes, your RNA expression also changes, says Dr. She. Changes may or may not be permanent, but the goal is to connect the pieces and see which changes amount to type 1 diabetes, he says.

MCGs TEDDY Clinical Center is screening newborns in nine hospitals, including MCG Medical Center, University Hospital, Trinity Hospital of Augusta; Northside, Piedmont and Kennestone Hospitals in Atlanta; and three hospitals in Gainesville, Fla. Additional centers include Barbara Davis Center at the University of Colorado; Pacific Northwest Research Institute in Seattle; the University of Turku in Finland; Lund University in Sweden; and the Diabetes Research Institute in Munich, Germany. The University of South Florida in Tampa serves as the TEDDY data coordinating center and MCGs new contract with the NIDDK for nucleic acid isolation is through that university.

To date, MCGs center has enrolled about 500 children. An additional 800 to 1,000 enrollees in the next two-and-one-half years are planned.


Contact: Toni Baker
Medical College of Georgia  

Related medicine news :

1. Brooke Franchise Corporation Announces Selected July Results
2. Corbett Selected to Host the Only Midwest Global Awards Judging Competition
3. Draxis Health selected by Johnson and Johnson Consumer Companies, Inc. for major contract manufacturing relationship
4. Crdentia Selected by High Rock Raceway to Provide Healthcare Staffing Services
5. Fry Construction Selected for High-Profile Medical Imaging Project
6. Meth Project Advertisements Selected for National Prevention Campaign
7. Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship
8. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
9. SAIC Selected to Support the U.S. Military Theater Medical Information Program-Joint
10. The Cooper Institutes FITNESSGRAM Selected as Statewide Physical Fitness Assessment Tool
11. CBaySystems Selected to Receive Deloittes 2007 Maryland Technology Fast 50 Award
Post Your Comments:
Related Image:
MCG selected as RNA laboratory for worldwide diabetes study
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: