Navigation Links
MAD: Scientists shed light on braking mechanisms in cellular signaling
Date:6/5/2014

Stanford, CA A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals about prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.

Researchers at UC Berkeley, the Plant Gene Expression Center, UC San Francisco, and the Carnegie Institution for Science identified a novel mechanism by which the strength of such an external signal is reduced, or attenuated. Their work focuses on the tiny mustard plant Arabidopsis, which is frequently used by scientists as an experimental model. Their findings are published in Science June 6.

Attenuation of signaling is analogous to the brakes on a car. While acceleration is desirable, acceleration without restraint can be disastrous. In this research, Arabidopsis seedlings were taken from subterranean darkness into sunlight, which triggered a response leading to "rapid and extensive" redirection of gene expression, ultimately resulting in familiar green seedlings.

But a brake on this acceleration of new gene expression is also necessary to restabilize the cells at a new equilibrium. The research team discovered a nuclear-localized, bimolecular signaling configuration by which the braking mechanism is directly linked to the accelerator, thereby providing simultaneous acceleration and restraint. By identifying the mechanism involved in this attenuation process, the team's discovery has potential implications ranging from agricultural to cancer research.

Cellular signaling triggered by external cues such as sunlight enables organisms to adapt to the prevailing conditions. When the organism perceives something that requires a response, a series of chemical signals is activated. This signaling is generally very robust at first. But at some point it is necessary to dial it back or turn it off entirelya restraint that falls to different, less-understood signaling pathways. These types of restraint functions are of great importance but poorly understood, as scientists have focused mostly on how the cells get stimulated in the first place.

Light-signaling in Arabidopsis involves the binding of an activated photoreceptor molecule (called phytochrome) to a transcription factor (gene-switch) called PIF. This binding destroys PIF, switching off its target genes. However, the researchers found that in imposing PIF's destruction, phytochrome signs its own death warrant and is simultaneously executed, thus reducing the incoming light-signaling intensity.

"Understanding such molecular mechanisms underlying the light response kinetics is important for engineering crops that can better adapt to environmental fluctuations," said Carnegie's Zhiyong Wang, one of the co-authors.

This bimolecular mutually assured destruction (MAD) mechanism of signaling attenuation appears to represent a new configuration, thus broadening our understanding of the range of mechanisms nature has evolved for this critical function.


'/>"/>

Contact: Zhiyong Wang
zwang@carnegiescience.edu
650-739-4205
Carnegie Institution
Source:Eurekalert

Related medicine news :

1. Scientists generate long-sought molecular map of critical genetic machinery
2. Scripps Florida scientists unravel the molecular secret of short, intense workouts
3. New nanomedicine by NTU and SERI scientists to bring relief to glaucoma patients
4. Scripps Research Institute scientists win $13 million grant in AIDS vaccine effort
5. Mice with mohawks help scientists link autism to 2 biological pathways in brain
6. Temple scientists receive $11.5 million grant for heart failure research
7. TSRI scientists catch misguided DNA-repair proteins in the act
8. Scientists seek answers with space station thyroid cancer study
9. MIPT scientists develop algorithm for anti-aging remedy search
10. Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug
11. Scientists slow brain tumor growth in mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... AccentCare, a leader in post-acute health care, have expanded their existing home health ... Home Health. , AccentCare has been operating a joint venture home health company ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
Breaking Medicine Technology: