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MAD: Scientists shed light on braking mechanisms in cellular signaling
Date:6/5/2014

Stanford, CA A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals about prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.

Researchers at UC Berkeley, the Plant Gene Expression Center, UC San Francisco, and the Carnegie Institution for Science identified a novel mechanism by which the strength of such an external signal is reduced, or attenuated. Their work focuses on the tiny mustard plant Arabidopsis, which is frequently used by scientists as an experimental model. Their findings are published in Science June 6.

Attenuation of signaling is analogous to the brakes on a car. While acceleration is desirable, acceleration without restraint can be disastrous. In this research, Arabidopsis seedlings were taken from subterranean darkness into sunlight, which triggered a response leading to "rapid and extensive" redirection of gene expression, ultimately resulting in familiar green seedlings.

But a brake on this acceleration of new gene expression is also necessary to restabilize the cells at a new equilibrium. The research team discovered a nuclear-localized, bimolecular signaling configuration by which the braking mechanism is directly linked to the accelerator, thereby providing simultaneous acceleration and restraint. By identifying the mechanism involved in this attenuation process, the team's discovery has potential implications ranging from agricultural to cancer research.

Cellular signaling triggered by external cues such as sunlight enables organisms to adapt to the prevailing conditions. When the organism perceives something that requires a response, a series of chemical signals is activated. This signaling is generally very robust at first. But at some point it is necessary to dial it back or turn it off entirelya restraint that falls to different, less-understood signaling pathways. These typ
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Contact: Zhiyong Wang
zwang@carnegiescience.edu
650-739-4205
Carnegie Institution
Source:Eurekalert

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