Navigation Links
M.D. Anderson-led team reports possible key to autoimmune disease
Date:9/17/2007

HOUSTON A human peptide that acts as a natural antibiotic against invading microbes can also bind to the bodys own DNA and trigger an immune response in the absence of an infection, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in an early online publication in Nature.

This combination of the peptide and self-DNA activates the same immune response pathway as a virus does, says senior author Michel Gilliet, M.D., assistant professor in M. D. Andersons Departments of Immunology and Melanoma Medical Oncology.

Researchers believe this response is both a likely key driver of autoimmune disease and an integral part of an early warning system that flags tissue damage to launch a protective inflammatory response to injury.

We show that this pathway may drive autoimmunity in psoriasis, a chronic inflammatory skin disease, Gilliet says. But the key peptide, called both LL37 and CAMP, is also heavily expressed in other autoimmune diseases such as inflammatory bowel disease and rheumatoid arthritis.

LL37 provides a new potential target to block in the treatment of chronic inflammatory diseases and a possible component for vaccines against infectious diseases and cancers, the authors note.

The team tracked down this new pathway by studying the activation of important immune defense cells in psoriasis. Plasmacytoid dendritic cells (pDCs) are highly specialized to recognize viral and other microbial infections. They engulf a virus and set off an immune system cascade to fight the infection by producing interferons.

Gilliet and colleagues previously showed that pDC activation in psoriatic skin drives the development of human psoriasis

These dendritic cells normally do not respond to self-DNA, Gilliet explains. This unresponsiveness prevents the cells from launching an attack on the bodys own tissue. However, researchers had accumulated evidence of a connection betw
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Autopsy reports could be valuable and informative
2. China reports declining number of SARS Cases
3. Russia Reports First SARS Case
4. Research reports that c-section deliveries are rising
5. Jharkhand reports 13,000 Malaria cases
6. Uganda Reports Failure To Contain Sleeping Sickness
7. WHO reports 36 million deaths world wide due to chronic diseases
8. Reports of Hantavirus infection in India raise concerns
9. Controversy Surrounding The HIV Positive Reports Of One-Year Girl In Kerala
10. China Reports Yet Another Bird Flu Case
11. China reports seventh bird flu victim
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... The Workgroup for Electronic Data Interchange ... use of health IT to create efficiencies in healthcare ... the United States Government Accountability Office (GAO) for a ... Medicare. The report, “ Potential Uses of Electronically Readable ... the public on Apr. 24, 2015 and examines the ...
(Date:5/1/2015)... Hope For The Warriors® thanks All ... The Warriors® and military families. All American Ford presented ... The Warriors®, a national nonprofit dedicated to restoring a ... hope for our service members and our military families. ... collected and matched small autograph fee from fans and ...
(Date:5/1/2015)... 2015 The Quail Creek Relay for Life ... Since 2001, the Quail Creek Relay team has raised almost ... throughout the year, including their biggest event, January’s Dinner and ... , Quail Creek Relay for Life team was established ... Kerwin, fitness director, states, “I was hooked when I learned ...
(Date:5/1/2015)... May 01, 2015 Digital technology and ... pregnant women between prenatal appointments, a preliminary study ... a small sample of low-risk pregnant women, will be ... Washington University Medical Faculty Associates at the 2015 American ... Scientific Meeting, May 2-6. The digital technology used was ...
(Date:5/1/2015)... Veteran Outreach Pittsburgh - Events , The ... VA Vet Centers on May 6, starting at 5 p.m., ... in front of the SouthSide Works Theater, 425 Cinema Drive, ... the documentary, “That Which I Love Destroys Me,” and a ... Please contact Robert Novotney for more information on the VA ...
Breaking Medicine News(10 mins):Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 2Health News:WEDI Contributes to Newly Released U.S. Government Accountability Office (GAO) Study on Potential Use of Electronically Readable Medicare Cards 3Health News:All American Ford Presents Donation to Nonprofit Hope For The Warriors 2Health News:Quail Creek Country Club’s Relay for Life Team Raised Over $89,000 for American Cancer Society 2Health News:Mobile Technology May Be Effective in Monitoring Pregnant Women Between Office Visits, Study Shows 2Health News:Mobile Technology May Be Effective in Monitoring Pregnant Women Between Office Visits, Study Shows 3
... Innovations, (Pink Sheets: SCLL) ACTIVTox(R) human liver toxicity tests ... standardized human liver cell line to identify potential toxicities ... is available now and can be used to help ... of our ACTIVTox testing system could help prevent recalls ...
... 21 Celator Pharmaceuticals today announced that it ... Inc. (Nasdaq: CEPH ). The ... application of Celator,s proprietary technology to an ongoing ... agreement provides an opportunity to leverage the technology ...
... MDdatacor, Inc ., a leader in health care ... today announced new functionality to support in tracking ... Care Program. The program is a collaboration between Wellmark ... to promote improved quality care and increased efficiency. ...
... Optimize Resources With Imaging, Behavioral and Chronic Management ... is now easier for providers and payors, thanks ... new Milliman Care Guidelines (R) 13th Edition. ... measures within the Care Guidelines, workflow ...
... are out the schoolroom door and off to the ... preventive steps to help protect their hearts.Prevention may be ... exercise, stay away from cigarettes and have check-ups.Be aware ... disorder known as Long QT Syndrome, research shows that ...
... Employer Interest in Their NicheDENVER, May 21 The ... their employees on international business trips to "get proactive" ... the state,s largest travel health provider."We are hearing from ... Reesman, president of Passport Health Colorado. "I think now ...
Cached Medicine News:Health News:FDA's Hydroxycut Recall Highlights the Need for Stem Cell Innovations' ACTIVTox Human Liver Testing 2Health News:FDA's Hydroxycut Recall Highlights the Need for Stem Cell Innovations' ACTIVTox Human Liver Testing 3Health News:Celator(R) Pharmaceuticals Initiates Research Agreement With Cephalon, Inc. 2Health News:Wellmark Leverages MDdatacor Technology to Streamline Immunization Tracking 2Health News:Wellmark Leverages MDdatacor Technology to Streamline Immunization Tracking 3Health News:Milliman Care Guidelines(R) Products Drive Efficiency Through Expanded Quality Tools 2Health News:Milliman Care Guidelines(R) Products Drive Efficiency Through Expanded Quality Tools 3Health News:Protect Your Kids' Hearts: Summer Activity Can Trigger Genetic Disorder, Say Results for Life, Sudden Cardiac Arrest Association 2Health News:Protect Your Kids' Hearts: Summer Activity Can Trigger Genetic Disorder, Say Results for Life, Sudden Cardiac Arrest Association 3Health News:H1N1 Scare Causes Businesses to Get Serious About Travel Health 2
(Date:4/30/2015)... 30, 2015   Regulus Therapeutics Inc . (NASDAQ: ... and development of innovative medicines targeting microRNAs, today announced ... the quarter ended March 31, 2015 on Thursday, May ... Regulus will host a conference call and ... Eastern Daylight Time to discuss its first quarter 2015 ...
(Date:4/30/2015)... CUPERTINO, Calif., April 30, 2015  DURECT Corporation (Nasdaq: ... first quarter of 2015.  Total revenues were $4.8 million ... months ended March 31, 2015 as compared to total ... million for the three months ended March 31, 2014.At ... $29.8 million, compared to cash and investments of $34.9 ...
(Date:4/30/2015)... 2015 Pharmacists at Osco Drug have voted to ... Portland, Maine . The newly organized group consists of ... Shaw,s supermarkets throughout Maine . ... in securing them the powerful representation that Teamsters Local 340 ... President of Local 340. "We will work tirelessly, providing them ...
Breaking Medicine Technology:Regulus Announces Timing for First Quarter 2015 Financial Results Webcast and Conference Call 2Regulus Announces Timing for First Quarter 2015 Financial Results Webcast and Conference Call 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 2DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 3DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 4DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 5DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 6DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 7DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 8DURECT Corporation Announces First Quarter 2015 Financial Results and Update of Programs 9
... 02, 2007 /PRNewswire-FirstCall/ - YM,BioSciences Inc. ... develops,and commercializes differentiated products for patients ... randomized,placebo-controlled Phase IIb trial of AeroLEF(TM) ... following orthopedic surgery.,AeroLEF(TM) met the primary ...
... 2, 2007 - Acorda Therapeutics, Inc.(R),(Nasdaq: ACOR) ... clinical trial,of Fampridine-SR in people with multiple ... meeting. Andrew Goodman, M.D.,Director of the Multiple ... top-line results on walking ability, leg,strength, spasticity ...
Cached Medicine Technology:YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets,Primary Endpoint in Patients with Post-Surgical Pain 2YM BioSciences Reports AeroLEF Randomized Phase IIb Trial Meets,Primary Endpoint in Patients with Post-Surgical Pain 3Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 2Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 3Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 4Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 5Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 6Acorda Therapeutics Presents Data from its Phase 3 Study of,Fampridine-SR in Multiple Sclerosis at the American Academy of,Neurology Meeting 7
... an easy-to-use, automated system that enables you ... for managing hemostatic disordersincluding D-Dimer, Von Willebrand ... reflex and rerun testing for greater efficiency ... our high-quality service to help your lab ...
... RX ACCUNET Embolic Protection System is designed ... filter control when performing carotid stenting interventions. ... based filter system that utilizes rapid exchange ... control the filter during catheter manipulations. It ...
Four disposable disc electrodes are pre-gelled and attached to wires in red, blue, black and green. 4mil carbon film, Ag/AgCl coated. Each package contains 20 individually sealed sets of four leads....
Lancet cut ultra sharp tip for low penetration resistance. Low noise and impedance level giving you a clear and reliable signal. Stainless steel needle, color coded attached lead wires. Needles sold ...
Medicine Products: