Navigation Links
M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
Date:11/13/2007

rtant because the carcinogenesis pathway observed in our model may be relevant to the more than 65 percent of human non-small cell lung cancers that don't have K-Ras mutations," Lotan says.

Expression of the gene was compared in 18 pairs of human non-small cell lung cancer and adjacent normal tissue. In 11 cases, or 61 percent, the tumors had lower levels of GPRC5A messenger RNA than did the nearby normal tissue. Two had higher levels of expression in the tumor and one pair had similar levels in both tissues. Four had no expression in either sample.

Next, the team used gene expression profiling with a microarray to compare 186 lung tumors to 17 normal control tissues. The four tumor types all had a fraction of the GPRC5A gene expression shown in the normal cells: adenocarcinoma 46.2 percent; squamous cell carcinoma at 7.5 percent; small-cell lung cancer at 5.3 percent; and carcinoid at 1.8 percent.

Finally, they inserted the GPRC5A gene back into lung cancer cell lines in a laboratory experiment, suppressing colony formation of human lung cancer cells by 91 percent in two cell lines.

"These findings suggest that GPRC5A can suppress lung cancer development in humans as well as mice," Lotan says.


'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. M.D. Anderson-led team reports possible key to autoimmune disease
2. UCI Medical Affiliates Inc. Opens a New Doctors Care Center in Anderson
3. M. D. Anderson-Prevention poll finds women can do more to prevent cancer...but arent
4. M. D. Anderson-Prevention poll finds women can do more to prevent cancer ... but arent
5. Stanford researchers find culprit in aging muscles that heal poorly
6. UCLA researchers identify markers that may predict diabetes in still-healthy people
7. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
8. Bipolar disorder relapses halved by Melbourne researchers
9. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
10. High and mighty: first common height gene identified by researchers behind obesity gene finding
11. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... 2015 , ... When it comes to undergoing a hair transplant, most patients have donor hair ... more volume to the hair on top of the scalp, as well as filling in ... of donor hair on other areas of their head. , What about patients who have ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... ... management, recently opened registration for the company’s second Introduction to Hyperbaric Medicine Course. ... October 15-18, 2015 aboard the Queen Mary Hotel in Long Beach, CA. The ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... geared to patients and family members, medical professionals, and researchers, covering a variety ... The conference is a collaborative effort between the Mesothelioma Applied Research Foundation ...
(Date:8/31/2015)... ... August 31, 2015 , ... Patients who thought about ... who are interested in learning more about the procedure beyond the information found on ... Internationally recognized hair transplant surgeon Parsa Mohebi will be on hand to answer patients ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Sundance Film Festival award winning documentary “Alive ... “Alive Inside” shadows a social worker who advocates for the use of music therapy ... bringing music to residents in health care centers who may have lost a spark ...
Breaking Medicine News(10 mins):Health News:Body Hair Transplants to Help Achieve a Full Head of Hair 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 2Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 3Health News:Registration Opens for Wound Care Advantage’s Second UHMS Approved 40-Hour Introduction to Hyperbaric Medicine Course 4Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 2Health News:New York Experts on Mesothelioma Come Together at Memorial Sloan Kettering Cancer Center 3Health News:Watch a Live Hair Transplant at Parsa Mohebi Hair Restoration’s Open House 2Health News:Public Invited to Dementia Documentary Screening at North Carolina Retirement Community 2
... Delhi government has decided to construct 36 hospitals.// ... ,"Some of these hi-tech hospitals will be built in ... the chief minister's office. ,"Initially the government had ... but more funds will be made available," the official said. ...
... HIV tests of dental patients in North Quensland. The ... a dentist working// at Bowen and Collinsville hospitals, tested ... testing of patients. Nearly 120 patients have already been ... Jeannette Young expressed that despite some patients getting ...
... during pregnancy do more harm than good according to ... study conducted by researchers revealed that babies born to ... antidepressants have more of a likelihood of having a ... is in contradiction to the belief that treating depressed ...
... the elderly has been blamed on defects in a specific gene ... estimated that about 37% of Britons from ages 61 to 70 ... people are said to have age-related hearing loss. ,The ... changes in the gene, KCNQ4 more frequent among those with age-related ...
... the High-Security Animal Disease Laboratory in Bhopal have finally helped ... against// the deadly H5N1 bird flu virus last month. However, ... to manufacture the vaccine. ,This is because there ... influenza vaccines for poultry who has a Bio Safety Level ...
... West Java province, poultry depopulation is being conducted by culling ... of// avian flu in this area. ,According to ... Rachmat said that this plan of mass culling was made ... tested positive for bird flu. ,According to Andi, ...
Cached Medicine News:Health News:Gene linked to Hearing Loss in Aged Identified 2Health News:Major Hurdle towards Development of Bird Flu Vaccine in India. 2
(Date:8/31/2015)... 31, 2015  The departments of Drug and Alcohol ... Gaudenzia Concept 90 to raise awareness for International Overdose ... Pennsylvania and help more Pennsylvanians ... recovery through the Building Bridges to Recovery ... every day to a disease that is fully treatable, ...
(Date:8/31/2015)... and MOUNTAIN VIEW, Calif. ... SNY ; EURONEXT: SAN) and the life sciences ... to improve care and outcomes for people with type ... in diabetes treatments and devices with Google,s expertise in ... companies will explore how to improve diabetes care by ...
(Date:8/31/2015)... , Aug. 31, 2015  Asterias Biotherapeutics, Inc. ... the emerging field of regenerative medicine, today announced ... Chicago -based Rush University Medical ... activity of escalating doses of AST-OPC1 (oligodendrocyte progenitor ... motor complete cervical spinal cord injury (SCI). This ...
Breaking Medicine Technology:Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 4Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 5Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 6Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6
... in the New England ... and JACKSONVILLE, Fla., March 24 A study published ... Medicine suggests that intensive blood glucose (sugar) control ... does not improve outcomes and is associated with an ...
... 24 Anthera Pharmaceuticals, Inc., a privately held biopharmaceutical company ... of safety and efficacy data from the first cohort of ... recommended that Anthera,s Phase II clinical trial, known as the ... P hospholipase in A cute C hes ...
Cached Medicine Technology:Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 2Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 3Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients 4Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease 2Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease 3
The Natural Selection family of specialty allografts is spinal concepts response to surgeon requests for spinal allograft devices to eliminate the need for painful autograft harvesting....
Transcranial vascular DWL doppler....
Transcranial vascular DWL doppler....
... Neurocare is a full-featured physiologic testing system offered ... contains many of the features of our flagship ... economical price. , ,The smaller size of the ... environment, the physician's office, a mobile service or ...
Medicine Products: