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M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
Date:11/13/2007

rtant because the carcinogenesis pathway observed in our model may be relevant to the more than 65 percent of human non-small cell lung cancers that don't have K-Ras mutations," Lotan says.

Expression of the gene was compared in 18 pairs of human non-small cell lung cancer and adjacent normal tissue. In 11 cases, or 61 percent, the tumors had lower levels of GPRC5A messenger RNA than did the nearby normal tissue. Two had higher levels of expression in the tumor and one pair had similar levels in both tissues. Four had no expression in either sample.

Next, the team used gene expression profiling with a microarray to compare 186 lung tumors to 17 normal control tissues. The four tumor types all had a fraction of the GPRC5A gene expression shown in the normal cells: adenocarcinoma 46.2 percent; squamous cell carcinoma at 7.5 percent; small-cell lung cancer at 5.3 percent; and carcinoid at 1.8 percent.

Finally, they inserted the GPRC5A gene back into lung cancer cell lines in a laboratory experiment, suppressing colony formation of human lung cancer cells by 91 percent in two cell lines.

"These findings suggest that GPRC5A can suppress lung cancer development in humans as well as mice," Lotan says.


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Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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