Navigation Links
M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
Date:11/13/2007

HOUSTON - The GPRC5A gene, which is under-expressed in human lung cancer cells, suppresses lung tumors in mouse models and could provide a key to attacking lung cancer in humans, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 21 edition of The Journal of the National Cancer Institute.

The study found that mice with both of their GPRC5A genes suppressed developed normally until their second year of life, when 76 percent developed precancerous lesions called adenomas in their lungs and another 17 percent developed malignancies called adenocarcinomas. Only 10 percent of mice with both GPRC5A genes intact developed adenomas, and only 11 percent with one working version of the gene. None of the mice in the latter two groups developed lung cancer.

"In humans, lung adenocarcinomas are the most common type of lung cancer and the major cause of death from this disease," says senior author Reuben Lotan, Ph.D., professor in M. D. Anderson's Department of Thoracic/ Head and Neck Medical Oncology. "Further study substantiating the role of the GPRC5A gene in human lung cancer could lead to the development of novel approaches for lung cancer prevention, diagnosis and treatment."

Lung cancer is the leading cause of deaths by cancer, killing 160,000 Americans annually.

Lotan and colleagues earlier had shown that Gprc5a protein is detected in the lungs more than in any other tissue and that it is underexpressed in human non-small cell lung cancer and in head and neck squamous cell carcinoma.

The mouse model experiments were designed to follow-up on these early clues of a tumor-suppressing role for the gene. Loss of a tumor-suppressor gene product such as Gprc5a protein is an important step in cancer development.

The team also found that the tumors generated in the mice without the genes lacked mutations to the K-Ras gene, a common oncogene that fuels cancer growth. "This may be impo
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. M.D. Anderson-led team reports possible key to autoimmune disease
2. UCI Medical Affiliates Inc. Opens a New Doctors Care Center in Anderson
3. M. D. Anderson-Prevention poll finds women can do more to prevent cancer...but arent
4. M. D. Anderson-Prevention poll finds women can do more to prevent cancer ... but arent
5. Stanford researchers find culprit in aging muscles that heal poorly
6. UCLA researchers identify markers that may predict diabetes in still-healthy people
7. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
8. Bipolar disorder relapses halved by Melbourne researchers
9. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
10. High and mighty: first common height gene identified by researchers behind obesity gene finding
11. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... News) -- Over the next two decades, the cost ... to more than double, topping more than $180 billion ... factor driving the increase: an aging population. The report, ... Stroke Association, was published May 22 in the journal ... health care system," Dr. Bruce Ovbiagele, chairman of the ...
(Date:5/22/2013)... HealthDay Reporter , , WEDNESDAY, May 22 (HealthDay ... great deal of suffering, but new research indicates the ... else entirely -- a smaller brain. , , Already ... of depression, scientists wanted to determine if having both ... size -- about 2 percent -- isn,t alarming, study ...
(Date:5/22/2013)... Johns Hopkins researchers report that hospitals may be ... are complicated by preventable bloodstream infections contracted in ... new study, reported online in the American ... that an ICU patient who develops an avoidable ... times more to care for than a similar ...
(Date:5/22/2013)... 22, 2013 Award Presented at the ... press release here: http://bit.ly/13DkFfk , Merrill Corporation ... “Information Management Product/Service of the Year” at the 7th ... The Colony Hotel in Palm Beach, Florida. , ... room (VDR) solution that optimizes the due diligence ...
(Date:5/22/2013)... 22, 2013 Phelps Memorial Hospital Center ... Westchester Lung Nodule Center for individuals who would like ... care. Lung cancer is the deadliest form of cancer for ... the U.S. die from lung cancer than from breast, colon ... early detection increases survival rates. It is well established ...
Breaking Medicine News(10 mins):Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 2Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 3Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 2Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 3Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 2Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 3
... Recent study reports that women don’t have to worry about their ... fertility is higher only in their thirties. // Women don’t have ... be a constraint for conception of babies. Researchers have found from ... as man as increased considerably. The fertility rate of women in ...
... as formed a new cabinet committee to plan strategies to ... has said that though the United Kingdom //Government has taken ... flu spread but the committee feels still a lot has ... ,The committee feels that the Government should organize the food ...
... Motion has been developed by University of Toronto scientists with ... again. The device makes the muscles// work again by sending ... called functional electrical stimulation or FES, is unlike similar therapies ... is not dependent on the machine. ,Instead, the ...
... it takes to get pregnant or conceive the sex of the ... by Dutch reserachers. //The sample size was 5,283 women who gave ... ,Among the 498 women who took longer than 12 months ... whereas the proportion of male births among the 4,785 women with ...
... UK Parliamentarian Roger Williams has called for a ban ... the production of 6,000 types of medicines, food and ... the sweetener, which is used in cereal, chocolate and ... published reports that aspartame caused cancer in rats. Doses ...
... the Government in treating drug addicts is beginning to yield ... users seeking treatment in 2004. Heroin users accounted for 8,000 ... the number of people trying to get back to normal ... the figures, which also said that the percentage of heroin ...
Cached Medicine News:
(Date:5/22/2013)... , May 22, 2013  Flagship Ventures, a ... on healthcare and sustainability, today announced the appointment ... a Senior Partner. In this role, Mr. Bancel ... companies. In addition to working closely ... also serves as President and Chief Executive Officer ...
(Date:5/22/2013)... and TORONTO , May 22, ... today that John Mon , Chief Operating ... Conference on Thursday, May 30, 2013 in New ... The Company,s presentation is scheduled to begin at ... webcast. To access the webcast, go to:   http://wsw.com/webcast/marcum/mfs.v/   ...
(Date:5/22/2013)... May 22, 2013 While many parents may ... to drink at home under adult supervision keeps kids ... truth is that there are serious negative consequences for ... and The Treatment Research Institute (TRI) ... resource for parents and caregivers to help inform them ...
Breaking Medicine Technology:Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 2Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 3Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 2Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 4Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 5Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 6Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 7
... July 14 D3 Radiation Services announced today  that the ... reduce errors in the delivery of radiation therapy--as a Practice Quality Improvement ... , , ... radiation oncology physicists can order a comprehensive audit of their beam data ...
... 14 Mylan Inc. (Nasdaq: MYL ) ... received final approval from the U.S. Food and Drug ... for Nabumetone Tablets USP, 500 mg and 750 mg. ... therapeutically equivalent to Nabumetone Tablets, a treatment for osteoarthritis ...
Cached Medicine Technology:eDataAudit Receives Approval from the American Board of Radiology 2Mylan Receives Approval for Nabumetone Tablets 2
Straight, with guard. Ideal for multi-directional manipulation....
Vaulted shank with guard....
Vaulted shank. For engaging the inferior haptic without touching the dome of the IOL....
... adjusted for perfect focus where it's needed ... This, along with Keeler's wide angle light ... the patient's pupil size, you will see ... Lithium-ion technology provides a longer life battery ...
Medicine Products: