Navigation Links
M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
Date:11/13/2007

HOUSTON - The GPRC5A gene, which is under-expressed in human lung cancer cells, suppresses lung tumors in mouse models and could provide a key to attacking lung cancer in humans, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 21 edition of The Journal of the National Cancer Institute.

The study found that mice with both of their GPRC5A genes suppressed developed normally until their second year of life, when 76 percent developed precancerous lesions called adenomas in their lungs and another 17 percent developed malignancies called adenocarcinomas. Only 10 percent of mice with both GPRC5A genes intact developed adenomas, and only 11 percent with one working version of the gene. None of the mice in the latter two groups developed lung cancer.

"In humans, lung adenocarcinomas are the most common type of lung cancer and the major cause of death from this disease," says senior author Reuben Lotan, Ph.D., professor in M. D. Anderson's Department of Thoracic/ Head and Neck Medical Oncology. "Further study substantiating the role of the GPRC5A gene in human lung cancer could lead to the development of novel approaches for lung cancer prevention, diagnosis and treatment."

Lung cancer is the leading cause of deaths by cancer, killing 160,000 Americans annually.

Lotan and colleagues earlier had shown that Gprc5a protein is detected in the lungs more than in any other tissue and that it is underexpressed in human non-small cell lung cancer and in head and neck squamous cell carcinoma.

The mouse model experiments were designed to follow-up on these early clues of a tumor-suppressing role for the gene. Loss of a tumor-suppressor gene product such as Gprc5a protein is an important step in cancer development.

The team also found that the tumors generated in the mice without the genes lacked mutations to the K-Ras gene, a common oncogene that fuels cancer growth. "This may be important because the carcinogenesis pathway observed in our model may be relevant to the more than 65 percent of human non-small cell lung cancers that don't have K-Ras mutations," Lotan says.

Expression of the gene was compared in 18 pairs of human non-small cell lung cancer and adjacent normal tissue. In 11 cases, or 61 percent, the tumors had lower levels of GPRC5A messenger RNA than did the nearby normal tissue. Two had higher levels of expression in the tumor and one pair had similar levels in both tissues. Four had no expression in either sample.

Next, the team used gene expression profiling with a microarray to compare 186 lung tumors to 17 normal control tissues. The four tumor types all had a fraction of the GPRC5A gene expression shown in the normal cells: adenocarcinoma 46.2 percent; squamous cell carcinoma at 7.5 percent; small-cell lung cancer at 5.3 percent; and carcinoid at 1.8 percent.

Finally, they inserted the GPRC5A gene back into lung cancer cell lines in a laboratory experiment, suppressing colony formation of human lung cancer cells by 91 percent in two cell lines.

"These findings suggest that GPRC5A can suppress lung cancer development in humans as well as mice," Lotan says.


'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. M.D. Anderson-led team reports possible key to autoimmune disease
2. UCI Medical Affiliates Inc. Opens a New Doctors Care Center in Anderson
3. M. D. Anderson-Prevention poll finds women can do more to prevent cancer...but arent
4. M. D. Anderson-Prevention poll finds women can do more to prevent cancer ... but arent
5. Stanford researchers find culprit in aging muscles that heal poorly
6. UCLA researchers identify markers that may predict diabetes in still-healthy people
7. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
8. Bipolar disorder relapses halved by Melbourne researchers
9. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
10. High and mighty: first common height gene identified by researchers behind obesity gene finding
11. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... 2016 Research and Markets ... Electronics 2015-2025: Applications, Technologies, Forecasts" report to ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, Composite ... Structural electronics involves electronic and/or electrical components and ... dumb structures such as vehicle bodies or conformally ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: