Navigation Links
Lymphoma patients with cardiovascular disease have increased risk of cardiac hospitalization
Date:7/2/2010

(WASHINGTON, July 1, 2010) Older patients with Hodgkin lymphoma (HL) and a history of heart disease face a high risk of hospitalization for cardiac complications after completing treatment, according to research published online today in Blood, the journal of the American Society of Hematology. HL is a form of cancer of arising in the lymph nodes, and approximately 8,500 people were diagnosed with the disease in 2009, according to the American Cancer Society. Treatment for HL typically includes the drug doxorubicin as part of chemotherapy and may also include radiation therapy to lymph nodes in the chest. Although treatment produces high cure rates, these treatments can also be toxic to the heart. This makes treating patients with pre-existing heart disease particularly challenging.

To evaluate the toxicity of HL treatment, researchers collected data on hospitalizations for heart disease among 1,096 HL patients who had received common treatment regimens, including doxorubicin-containing chemotherapy and radiation therapy to lymph nodes in the chest.

The study found that the toxicity of different treatments varied significantly depending on whether patients had pre-existing heart disease. In particular, radiation therapy to the chest appeared to increase the risk of cardiac hospitalization to a much greater degree among those with pre-existing heart disease than among those without. Also, patients with heart disease whose treatment included radiation therapy to the chest were found to be approximately 2.5 times more likely to be hospitalized for cardiac reasons than those who were treated with chemotherapy alone.

"Efforts to reduce cardiac exposure to radiation in patients with pre-existing cardiac disease are warranted based on these findings," said David Hodgson, MD, David Hodgson, radiation oncologist at the Princess Margaret Hospital Cancer Program, University Health Network, investigator at the Institute of Clinical Evaluative Sciences, Ontario, Canada, and senior author of the study. "However, the lower cardiac complication rate among patients treated only with chemotherapy occurred in part because they were more likely to die of other causes, so it is not a simple message that chemotherapy alone is better for all patients. Clinical trials are ongoing to more accurately identify which patients benefit from radiation therapy and to further reduce the administered dose to normal tissues," Hodgson said. "But oncologists need to be be aware of their patients' heart health and vigilant about post-treatment monitoring and active intervention to reduce their patients' cardiac risk factors."

Possible explanations for this relationship have been cited in animal studies that have shown that when an artery is exposed to radiation, inflammation appears in the arterial wall and can lead to the rupture of fatty deposits, which is a common cause of heart attacks in humans. This may, in part, explain the increased risk of heart problems following radiation therapy to the chest in patients who likely have such fatty deposits in their coronary arteries.


'/>"/>

Contact: Wendy Stokes
wstokes@hematology.org
202-552-4927
American Society of Hematology
Source:Eurekalert

Related medicine news :

1. Lymphoma Survivors Often Miss Out on Follow-Up
2. Study shows Hodgkin lymphoma survivors lack post-treatment screening for other cancers
3. Study identifies promising treatment for aggressive lymphoma
4. Lifestyle Affects Survival in Non-Hodgkins Lymphoma
5. Lifestyle factors significantly impact survival of non-Hodgkins lymphoma patients, study finds
6. Scott & White Healthcare clinical trials target lymphoma, leukemia
7. Vitamin K may protect against developing non-Hodgkins lymphoma, say Mayo Clinic researchers
8. New class of drug kills lymphoma cells
9. Vitamin D Linked to Survival in Lymphoma Patients
10. A new target for lymphoma therapy
11. Data from Phase 1 Study Confirm High Response Rate of Micromets Blinatumomab in Patients with Non-Hodgkins Lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... Beach, Florida (PRWEB) , ... July 25, 2017 ... ... employee, Jennifer Haller, to the sales department joining as Regional Account Manager for ... relationships with contracted customers in the liquidation of their obsolete medical assets. , ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... and finance management services to communities across North Carolina, is launching a charity ... to raise community support for the ongoing fight against bladder cancer. , The ...
(Date:7/25/2017)... ... 25, 2017 , ... Dr. Donna Bergman, professor of education ... published an article in the medical science journal Physical Medicine and Rehabilitation titled ... and the research that helped produce it, were written and conducted in collaboration ...
(Date:7/25/2017)... , ... July 25, 2017 , ... ... as medical director. Dr. Negrette has more than a decade of experience in ... worked closely with individuals fighting addictions, eating disorders, psychotic and manic conditions, as ...
(Date:7/25/2017)... , ... July 25, 2017 , ... ... for its Product Innovation in the prestigious CEO World Awards®. The coveted annual ... new products and services, CEO case studies, corporate social responsibility, and milestones from ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... 2017 Did you know that PhRMA member companies invested ... combined spending on brand medicines, generics and the supply chain account ... for just half of this (7 percent)? Or that ... world,s venture capital investments in high-growth biopharmaceutical startups? ... The ...
(Date:7/17/2017)... 17, 2017  MedX Holdings, Inc., the manufacturer and ... and rehabilitation equipment, today announced the national roll out ... considered the gold standard for the treatment of low ... strengthening equipment. How ... physician or practice who prescribe the MedX Home Back ...
(Date:7/14/2017)... LAS VEGAS , July 13, 2017 It ... the United States is in the midst of ... Disease Control , since 1999, the number of overdose deaths ... , "resulting in over half a million dead from 2001 ... like codeine, oxycodone, and hydrocodone has similarly quadrupled, drawing a ...
Breaking Medicine Technology: