Navigation Links
Lymphatic vessel and lymph node function are restored with growth factor treatment
Date:12/3/2007

The frequent spread of certain cancers to lymph nodes often necessitates surgery or radiation therapy that damages the lymphatic system and can cause lymphedema, a condition of localized fluid retention that often increases susceptibility to infections.

The researchers of the University of Helsinki, Finland, and the Ludwig Institute of Cancer Research show that application of vascular endothelial growth factor-C (VEGF-C) to replace excised mouse lymph nodes and lymph vessels ensures formation of mature lymphatic vessels and incorporation of lymph node transplants into existing lymphatic vasculature. An improved outcome of lymph node transplantation is evidenced by improved lymphatic drainage and restoration of normal lymphatic vascular anatomy in VEGF-C-treated mice.

The ability to transfer lymph nodes that reconstitute a functional network of lymphatic vessels in adult tissues is of particular importance in cancer follow-up therapy, as lymph nodes can prevent systemic dissemination of metastases. Accordingly, VEGF-C-treated lymph nodes were more effective in trapping metastatic tumor cells than control transplants.

It has been estimated that approximately 20-30% of patients that have undergone irradiation or surgery of the armpit in response to lymph node metastases develop lymphedema later on. Damage to the large collecting lymphatic vessels, which resemble smaller veins, causes the vast majority of all lymphedemas. It has been estimated that several million patients suffer from such acquired lymphedema worldwide. The treatment of lymphedema is currently based on physiotherapy, compression garments and occasionally surgery, but means to reconstitute the collecting lymphatic vessels and cure the condition are limited.

The Finnish researchers applied vascular endothelial growth factor-C (VEGF-C) gene therapy in mice after surgery removal of axillary lymph nodes, a procedure that mimicked removal of axillary lymph nodes in patie
'/>"/>

Contact: Tuomas Tammela
tuomas.tammela@helsinki.fi
358-445-385-272
University of Helsinki
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mayo Clinic clarifies diagnosis for serious blood vessel disease of brain and spinal cord
2. Modest gain in visceral fat causes dysfunction of blood vessel lining in lean, healthy humans
3. Blood-vessel blocker aids cancer-killing virus
4. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
5. Chronic infection persists by targeting stromal cell network in lymphoid organs
6. Cephalon Submits New Drug Application for TREANDA for the Treatment of Chronic Lymphocytic Leukemia
7. Less invasive lymph node biopsy method could spare thousands unnecessary operations
8. The Leukemia & Lymphoma Society Provides Patients with the Latest Information on Myeloma
9. Micromet Receives Regulatory Approval to Conduct a Phase 2 Clinical Trial Investigating MT103 (MEDI-538) in Patients with Acute Lymphoblastic Leukemia
10. Cell Therapeutics, Inc. (CTI) Plans to Submit Supplemental Biologics License Application (sBLA) for ZEVALIN(R) Consolidation of First Remission in Advanced Stage Follicular Lymphoma in 2008
11. January 1 Looms Large for Lymphoma Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Bedros Keuilian is not only the founder ... camps, he’s also considered the leading expert on marketing ... business summits, a line of high-demand fitness marketing systems ... Spike TV reality show to his name. , With ... for personal trainers and fitness business owners to focus ...
(Date:10/1/2014)... WASHINGTON, D.C. and ATLANTA (PRWEB) October 01, ... and information security executive networking and relationship-marketing ... the 2014 Information Security Executive® and Project ... Executives include top-ranking decision makers representing organizations ... and academics. Projects include large-scale technology endeavors ...
(Date:10/1/2014)... Beverly Hills licensed Clinical Psychologist and ... 20 years of private practice in her Beverly Hills ... achieve greater joy and fulfillment in their relationships. Dr. ... and suggestions for anyone who suspects they are in ... it or not, it’s not always easy to know ...
(Date:10/1/2014)... NoteSwift Inc., announced today their new NoteSwift™ ... 13.0. NoteSwift is the bridge between the EHR and ... document clinical information at the point of care. NoteSwift ... note by more than half – and virtually eliminates ... providers state impedes EHR use according to the June ...
(Date:10/1/2014)... Today in Bahir Dar, Ethiopia, at the occasion ... has gathered some 150 African and international leishmaniasis ... treatment safety and efficacy monitoring plan, carried ... Kenya, Sudan, Uganda, and Ethiopia, were presented to ... access to treatment of kala-azar with the combination ...
Breaking Medicine News(10 mins):Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2
... memory, language, and other cognitive skills after bypass surgery. ... or the pump used to replace heart function during ... The findings may lead to better approaches to prevent ... receive. , The study, published in the May Annals ...
... Murad, Inc. announced today,the appointment of Fernando ... Business for Latin America. In this position, Braga ... presence in key,areas, identify prospective partners and create ... http://www.newscom.com/cgi-bin/prnh/20080519/LAM066 ), "Fernando joins the Murad ...
... Diego, California, May 19, 2008 NPS Pharmaceuticals, Inc. ... data at the annual Digestive Disease Week (DDW) Congress ... reduce dependence upon parenteral nutrition (PN) in patients with ... , The Phase 3 study evaluated two ...
... ARLINGTON HEIGHTS, Ill., May 19 Plastic,surgeons performed ... ranging from repairing dog bite wounds and birth ... (Photo: http://www.newscom.com/cgi-bin/prnh/20080519/DC22812 ), Who ... has reconstructive,surgery changed their lives?, On average, ...
... The Epilepsy,Foundation today released important information about epilepsy and ... recent news about,Senator Edward Kennedy (D-Mass)., Senator Kennedy, ... S.,Senate, reportedly experienced a seizure on Saturday. A seizure ... One in ten Americans,will have a single seizure at ...
... smoke, chemicals boosts odds, but routine screening could ... may be at increased risk for bladder cancer and ... of California, San Francisco, researchers. , The team tested ... age was 45, and found that 93 tested ...
Cached Medicine News:Health News:Bypass not to blame for heart patients' mental decline 2Health News:Murad, Inc., Appoints Fernando Braga, Jr. as Director of International Business for Latin America 2Health News:Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome 2Health News:Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome 3Health News:Phase 3 GATTEX results presented at DDW highlight potential new treatment in short bowel syndrome 4Health News:Each Day, Plastic Surgeons Are Reconstructing Lives: Restoring Function, Improving Appearances, and Elevating Self-Esteem 2Health News:The Epilepsy Foundation Sheds Light on Seizures 2Health News:Firefighters May Face Higher Risk of Bladder Cancer 2
(Date:10/1/2014)... SAN MARCOS, Texas , Oct. 1, 2014 ... that it is scaling volume production of photoactive ... solar power technologies . While offering numerous advantages ... difficulty of producing large quantities of quantum dots ... has until now kept them from commercial utilization ...
(Date:10/1/2014)... 1, 2014 Ardelyx, Inc. (NASDAQ: ... company focused on cardio-renal, gastrointestinal and metabolic ... 371 patient Phase 2b clinical trial evaluating ... syndrome (IBS-C).  Results from this study demonstrated ... IBS-C symptoms for tenapanor-treated patients compared to ...
(Date:10/1/2014)... , Switzerland , October 1, ... leader in Clinical Genomics and Next Generation Sequencing (NGS) ... allowing clinicians to run full cystic fibrosis analysis in ... the identification and characterisation of all types of variants ... performance. Until now, it has not been ...
Breaking Medicine Technology:Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 2Quantum Materials Scaling Up Photoactive Quantum Dot Production for Solar Power Generation 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 2Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 4Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 5Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 6Sophia Genetics Launches Full CFTR Analysis in Single Clinical Grade NGS Experiment 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: