Navigation Links
Lymph node dissection is not essential in small screen-detected lung cancers, new research shows
Date:2/28/2011

Lymph node dissection, the current standard surgical treatment for localized non-small cell lung cancers, may be unnecessary in certain screen-detected early stage cases , according to a study published in the March issue of the Journal of Thoracic Oncology (JTO), the official journal of the International Association for the Study of Lung Cancer.

The risk of nodal involvement is very low in early-stage cancers with a maximum standard uptake value (maxSUV) of 2.0 or a nodule smaller than 10 millimeters, researchers found.

"As a consequence of advances in diagnostic imaging, such as high-resolution or spiral computed tomography, thoracic surgeons encounter more often than in the past small-sized lung cancers at an earlier and potentially curable stage," said lead researcher Dr. Giulia Veronesi, MD, director of the Lung Cancer Early Detection Unit in the Division of Thoracic Surgery at the European Institute of Oncology in Milan, Italy. "It has thus become increasingly crucial to choose the most advantageous treatment strategy, including surgical intervention."

A total of 5,201 asymptomatic volunteers were recruited for the Continuing Observation of Smoking Subjects (COSMOS) trial in 2004 and 2005. All were 50 years or older, heavy smokers (20 pack years) or former heavy smokers who had quit within the previous 10 years.

Over the course of the next five years, lung cancer was detected by screening in 97 patients who also satisfied the criteria for the study. The tumors in 91 of those patients (94%) were N0 and in six (6.2%) were N+. All patients with tumors smaller than 10 mm or with a maximum SUV of less than 2.0 (62 cases) were N0. Nodal metastases occurred only among the 29 patients (17%) with lung nodules greater than 10 mm and maxSUV of 2.0 or more.

"These two simple variables were reliable predictors of lymph node involvement in early stage lung cancer, and will make it possible to avoid nodal dissection in a considerable number of patients, reducing operating time and invasiveness, and also reducing the morbidity associated with nodal dissection such as recurrent nerve injury and chylothorax," Veronesi said. "By contrast, when both variables were above the cutoffs identified in this study, radical lymph node dissection the risk of occult nodal involvement was fairly high, suggesting a radical lymph node dissection.

"These results imply for the future not only the reduction of cases requiring lymph node dissection but will allow us to propose safely lung-sparing sublobar resections instead of lobectomy in many patients with very initial lung cancer," she said.


'/>"/>

Contact: Rene McGaw
renee.mcgaw@ucdenver.edu
303-724-5796
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Microbubbles to light the way to sentinel lymph nodes of breast cancer patients
2. Removing Many Lymph Nodes in Early Breast Cancer Not Always Needed: Study
3. Limited lymph node removal for certain breast cancer does not appear to result in poorer survival
4. MicroRNA-TP53 circuit connected to chronic lymphocytic leukemia
5. Gene Mutation Suggests New Treatment Target for Specific Lymphoma
6. Study Adds to Evidence That Rituximab Slows Lymphoma Symptoms
7. Novel imaging technique may reduce lymphedema in breast cancer patients
8. Weight-Lifting After Breast Cancer Wont Cause Lymphedema, Study Finds
9. Weightlifting slashes lymphedema risk after breast cancer treatment
10. Study identifies drug resistance of CLL in bone marrow and lymph nodes
11. Personalized vaccine for lymphoma patients extends disease-free survival by nearly 2 years
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was ... his family verbally and physically. , “When something upset him, he couldn’t control his emotions,” ... He would throw rocks at my other children and say he was going to kill ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and ... women in the world, and the most handsome men, look naturally attractive. Plastic ...
(Date:6/24/2016)... ... , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event ... that have been wounded in battle and their families. Venture Construction Group is a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
Breaking Medicine Technology: