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Lupus in women: New genetic risk factors identified
Date:1/20/2008

d other autoimmune diseases, which could lead to earlier, more accurate diagnoses, said Dr. John Harley, lead author and SLEGEN director, from the Oklahoma Medical Research Foundation. They identify biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers.

Thanks to this discovery, we can now focus our research on the specific biological pathways and genes identified and dissect the precise molecular mechanisms by which these genes contribute to the risk for lupus, added Dr. Rioux.

This latest find comes weeks following the identification of one of the first genetic risk factors for systemic lupus, published in the January 2008 issue of Nature Genetics. In our previous study, we identified that a gene called TNFSF4, important for the communication between different cells of the immune system, is also involved in the susceptibility to systemic lupus, said Dr Rioux. The technological advances that made these studies possible are truly revolutionizing our ability to identify genetic risk factors for common diseases and these discoveries represent a major advance in our efforts to use genetic information to improve on the diagnosis and treatment of our patients, concluded Dr. Jean-Claude Tardif, Director of the Research Center of the MHI and Professor of Medicine at the MHI and the Universit de Montral. Dr. Tardif also mentioned that this remarkable contribution to the advancement of medical knowledge confirms the value of Universit de Montrals strategy in the field of genetics and genomics, which is based upon targeting important medical questions, supporting world class researchers and their international collaborations, in order to have a significant impact on our health system and on the scientific, social and economic development of Quebec and Canada.


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Contact: Doris Prince
doris.prince@icm-mhi.org
51-437-633-303-074
University of Montreal
Source:Eurekalert

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