Navigation Links
Lupus in women: New genetic risk factors identified
Date:1/20/2008

Montreal, January 20, 2008 An international consortium of clinical scientists and genomics experts, including researchers from the Montreal Heart Institute (MHI) and Universit de Montral (UdeM), have uncovered multiple new genetic risk factors for systemic lupus erythematosus (SLE), commonly known as lupus. The large-scale genomic study is the first of its kind to investigate the genetic basis of lupus. Dr. John D. Rioux, associate professor of medicine at the MHI and UdeM, co-authored the study that appears in the January 20 online edition of Nature Genetics.

Systemic lupus can affect joints, kidneys, heart, lungs, brain and blood. The disease occurs in about 31 out of every 100,000 people and affects women nine times more frequently than men. Scientists believe that lupus is caused by genetic variants that interact with one another and the environment.

The research team studied the DNA of 720 women of European descent with lupus and 2,337 women without lupus. They scanned the entire genome for more than 317,000 single nucleotide polymorphisms (SNPs), which are locations on chromosomes where a single unit of DNA, or genetic material, may vary from one person to the next. The goal was to identify SNPs linked to lupus. They confirmed these results in another independent set of 1,846 women with lupus and 1,825 women without lupus.

The scientists found evidence of an association to three genes: ITGAM, KIAA1542 and PXK, and to a region of the genome that does not contain any known genes. ITGAM is important for both the adherence of immune cells and for cleaning up pathogens. KIAA1542 is important for translating the DNA code into proteins. PXK encodes a molecule that transmits signals and controls complex processes in cells. The scientists also found association in genes previously associated with lupus and other autoimmune diseases.

These results help to delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses, said Dr. John Harley, lead author and SLEGEN director, from the Oklahoma Medical Research Foundation. They identify biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers.

Thanks to this discovery, we can now focus our research on the specific biological pathways and genes identified and dissect the precise molecular mechanisms by which these genes contribute to the risk for lupus, added Dr. Rioux.

This latest find comes weeks following the identification of one of the first genetic risk factors for systemic lupus, published in the January 2008 issue of Nature Genetics. In our previous study, we identified that a gene called TNFSF4, important for the communication between different cells of the immune system, is also involved in the susceptibility to systemic lupus, said Dr Rioux. The technological advances that made these studies possible are truly revolutionizing our ability to identify genetic risk factors for common diseases and these discoveries represent a major advance in our efforts to use genetic information to improve on the diagnosis and treatment of our patients, concluded Dr. Jean-Claude Tardif, Director of the Research Center of the MHI and Professor of Medicine at the MHI and the Universit de Montral. Dr. Tardif also mentioned that this remarkable contribution to the advancement of medical knowledge confirms the value of Universit de Montrals strategy in the field of genetics and genomics, which is based upon targeting important medical questions, supporting world class researchers and their international collaborations, in order to have a significant impact on our health system and on the scientific, social and economic development of Quebec and Canada.


'/>"/>

Contact: Doris Prince
doris.prince@icm-mhi.org
51-437-633-303-074
University of Montreal
Source:Eurekalert

Related medicine news :

1. Scripps research scientists find new genetic mutation that halts the development of lupus
2. Lupus Foundation of America Urges Social Security Administration Not to Adopt Proposed 5-Day Rule
3. 2007: A Watershed Year for Lupus Research and Education
4. Lupus Foundation of America Offers Webchat for Parents of Teens with Lupus on December 12 at 3:00 p.m. Eastern Time
5. S.L.E. Lupus Foundation Gala Raises Record $3.2 Million for Lupus
6. Researchers investigate ways to detect lupus-associated kidney disease
7. Research suggests targeted treatment strategies for lupus
8. Mayo Clinic shows therapy effective for reducing lupus flares
9. Photo: New York Goes Orange for Pumpkin Festival and Lupus Awareness Month
10. New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs
11. October is Lupus Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology: