Navigation Links
Lung transplants not dangerous for children with cystic fibrosis, after all
Date:3/31/2008

St. Louis, Mo. and Chapel Hill, N.C. March 31, 2008 - Responding to a study published in the New England Journal of Medicine, which concluded that lung transplants were harmful for children with cystic fibrosis, articles published in the latest issue of Pediatric Transplantation refute the conclusions and argue that the highly influential research was severely flawed.

According to two rebuttals published in the acclaimed journal, the conclusions of the study on post-transplant survival rates led by Theodore G. Liou, M.D., of the University of Utah, Salt Lake City, were seriously flawed by misinterpreted statistics that created a strong bias against transplantation.

Dr. Liou, et al. are accomplished statisticians and honorable academicians, says Thomas M. Egan, M.D., of the University of North Carolina at Chapel Hill in his systematic rejection of the study. But sometimes statistics do not tell the truth.

Using covariates obtained up to three years before actual transplantation and when predicted survival was good, the calculated hazard ratios Lious study put forth were based on outdated information that did not reflect true benefit on a patient-by-patient basis at the time of actual transplant, contend Egan and Stuart C. Sweet, M.D. of Washington University, St. Louis.

Lious study also conflicts with findings from other sources, in which survival rates for pediatric CF lung transplant recipients were substantially higher. Furthermore, recent changes in the U.S. transplant allocation policy, which appears to be successfully directing organs to those more at risk of dying on the waiting list and with higher survival benefit, have rendered the findings of Lious work irrelevant.

Because uncritical acceptance of the study results by third party payers, referring physicians, and lung transplant centers could place children with cystic fibrosis who would likely benefit from lung transplants at risk, we appreciate Pediatric Transplantation providing this opportunity to rapidly publish an independent critique of the article, says Dr. Sweet.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families
2. New Heart Pump Helps Women Awaiting Transplants
3. Blood-incompatible infant heart transplants safe, may save more lives
4. Blood-Incompatible Heart Transplants Safe for Infants
5. Lung Transplants May Not Help Most Cystic Fibrosis Children
6. Alcohol may amplify chronic rejection in lung transplants
7. Bone marrow cell transplants help nerve regeneration
8. Cell Transplants Hold Promise for Heart Attack Survivors
9. UCLA Program Aims to Revolutionize Kidney Transplants
10. Rural Residents Get Fewer Organ Transplants: Study
11. National study will look at German-made heart pump for children needing heart transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... ... As a leading dental practice, Wall Centre Dental supports Stroke Awareness Month by ... gums in Vancouver, BC, may be developing gingivitis, the first stage of gum ... diabetes. Drs. Parviz Roshan, Siamak Tehrani and Milton Reskovich offer laser gum therapy to ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants ... focused on finding product improvements that could reduce the occurrence of unplanned extubations ... need help breathing or to provide medication. Sometimes, patient movement can cause unplanned ...
(Date:6/20/2017)... , ... June 20, 2017 , ... Uniform Advantage ... collection featuring seven new products designed to create tailored looks and athleisure-inspired outfits. UA ... and cotton easy care stretch twill. , With trendy looks hitting the medical community, ...
(Date:6/20/2017)... ... , ... John D'Eri, CEO of Rising Tide Car Wash , will ... during the Autism Society of America 's 49th annual conference to be held ... (DJFF) was founded in 2002 as the nation's first autism organization focused exclusively ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... radio program, The Sharon Kleyne Hour Power of Water, Global Climate Change and ... to the world’s water crisis and how it affects the human eyes. ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... that it will be presenting at the 7th annual LD Micro ... Erez Raphael , CEO, of DarioHealth will be giving the presentation ... on June 6th & 7th, 2017 at the Luxe Sunset Bel ... micro-cap space. About LD Micro ...
(Date:5/26/2017)... International plc (NASDAQ: ENDP ) announced today that ... Company in a fireside chat at Goldman Sachs, 38 th ... at 10:40 a.m. PT / 1:40 p.m. ET. The conference ... Palos Verdes, CA. A live webcast ... the Company,s website at http://www.endo.com/investors/overview . Participants should allow ...
(Date:5/22/2017)... VALLEY COTTAGE, N.Y. , May 22, 2017 ... natural antiviral treatment Gene-Eden-VIR/Novirin, announces the launch of ... in plain English, the results of a clinical ... after one year treatment with Gene-Eden-VIR/Novirin in individuals ... is important to note that there are no ...
Breaking Medicine Technology: