Navigation Links
Lung transplants not dangerous for children with cystic fibrosis, after all
Date:3/31/2008

St. Louis, Mo. and Chapel Hill, N.C. March 31, 2008 - Responding to a study published in the New England Journal of Medicine, which concluded that lung transplants were harmful for children with cystic fibrosis, articles published in the latest issue of Pediatric Transplantation refute the conclusions and argue that the highly influential research was severely flawed.

According to two rebuttals published in the acclaimed journal, the conclusions of the study on post-transplant survival rates led by Theodore G. Liou, M.D., of the University of Utah, Salt Lake City, were seriously flawed by misinterpreted statistics that created a strong bias against transplantation.

Dr. Liou, et al. are accomplished statisticians and honorable academicians, says Thomas M. Egan, M.D., of the University of North Carolina at Chapel Hill in his systematic rejection of the study. But sometimes statistics do not tell the truth.

Using covariates obtained up to three years before actual transplantation and when predicted survival was good, the calculated hazard ratios Lious study put forth were based on outdated information that did not reflect true benefit on a patient-by-patient basis at the time of actual transplant, contend Egan and Stuart C. Sweet, M.D. of Washington University, St. Louis.

Lious study also conflicts with findings from other sources, in which survival rates for pediatric CF lung transplant recipients were substantially higher. Furthermore, recent changes in the U.S. transplant allocation policy, which appears to be successfully directing organs to those more at risk of dying on the waiting list and with higher survival benefit, have rendered the findings of Lious work irrelevant.

Because uncritical acceptance of the study results by third party payers, referring physicians, and lung transplant centers could place children with cystic fibrosis who would likely benefit from lung transplants at risk, we appreciate Pediatric Transplantation providing this opportunity to rapidly publish an independent critique of the article, says Dr. Sweet.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families
2. New Heart Pump Helps Women Awaiting Transplants
3. Blood-incompatible infant heart transplants safe, may save more lives
4. Blood-Incompatible Heart Transplants Safe for Infants
5. Lung Transplants May Not Help Most Cystic Fibrosis Children
6. Alcohol may amplify chronic rejection in lung transplants
7. Bone marrow cell transplants help nerve regeneration
8. Cell Transplants Hold Promise for Heart Attack Survivors
9. UCLA Program Aims to Revolutionize Kidney Transplants
10. Rural Residents Get Fewer Organ Transplants: Study
11. National study will look at German-made heart pump for children needing heart transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San ... using cutting-edge Oventus O2Vent technology. As many as 18 million Americans are ... cessation in breathing. Oral appliances can offer significant relief to about 75 percent ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... Rockville, Maryland (PRWEB) , ... October 12, 2017 ... ... a magnetic drug delivery system that we intend to develop to enable prevention ... regimens can lead to severe hearing loss, especially in pediatric patients. For cisplatin, ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)...  AllianceRx Walgreens Prime, the combined central specialty pharmacy ... benefit manager Prime Therapeutics LLC (Prime), today officially began ... unveiling of new signage at its headquarters in ... a few other company-owned facilities across the country. This ... of whom will begin to see the AllianceRx Walgreens ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
Breaking Medicine Technology: