Navigation Links
Lung transplants not dangerous for children with cystic fibrosis, after all
Date:3/31/2008

St. Louis, Mo. and Chapel Hill, N.C. March 31, 2008 - Responding to a study published in the New England Journal of Medicine, which concluded that lung transplants were harmful for children with cystic fibrosis, articles published in the latest issue of Pediatric Transplantation refute the conclusions and argue that the highly influential research was severely flawed.

According to two rebuttals published in the acclaimed journal, the conclusions of the study on post-transplant survival rates led by Theodore G. Liou, M.D., of the University of Utah, Salt Lake City, were seriously flawed by misinterpreted statistics that created a strong bias against transplantation.

Dr. Liou, et al. are accomplished statisticians and honorable academicians, says Thomas M. Egan, M.D., of the University of North Carolina at Chapel Hill in his systematic rejection of the study. But sometimes statistics do not tell the truth.

Using covariates obtained up to three years before actual transplantation and when predicted survival was good, the calculated hazard ratios Lious study put forth were based on outdated information that did not reflect true benefit on a patient-by-patient basis at the time of actual transplant, contend Egan and Stuart C. Sweet, M.D. of Washington University, St. Louis.

Lious study also conflicts with findings from other sources, in which survival rates for pediatric CF lung transplant recipients were substantially higher. Furthermore, recent changes in the U.S. transplant allocation policy, which appears to be successfully directing organs to those more at risk of dying on the waiting list and with higher survival benefit, have rendered the findings of Lious work irrelevant.

Because uncritical acceptance of the study results by third party payers, referring physicians, and lung transplant centers could place children with cystic fibrosis who would likely benefit from lung transplants at risk, we appreciate Pediatric Transplantation providing this opportunity to rapidly publish an independent critique of the article, says Dr. Sweet.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. National Foundation for Transplants to Expand Program Providing Hotel Accommodations to Patient Families
2. New Heart Pump Helps Women Awaiting Transplants
3. Blood-incompatible infant heart transplants safe, may save more lives
4. Blood-Incompatible Heart Transplants Safe for Infants
5. Lung Transplants May Not Help Most Cystic Fibrosis Children
6. Alcohol may amplify chronic rejection in lung transplants
7. Bone marrow cell transplants help nerve regeneration
8. Cell Transplants Hold Promise for Heart Attack Survivors
9. UCLA Program Aims to Revolutionize Kidney Transplants
10. Rural Residents Get Fewer Organ Transplants: Study
11. National study will look at German-made heart pump for children needing heart transplants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), ... of an innovative new design of the shoulder pad. The shoulder pad provides ... while controlling your pain while using cold therapy. By utilizing ice and water that ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... , Sept. 13, 2017   OrthoAtlanta has been ... Atlanta Football Host Committee (AFHC) for the 2018 College Football ... 8, 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... the AFHC "I,m In" campaign, participating in many activities leading ... ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent ... as the number one company for hearing aids, ranking it ... fifteen other brands. ... Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, ...
(Date:9/9/2017)... ... DC ... th – Monday, September 18 th .The Brain Tumor Foundation (BTF) ... to the public.Where:  BTF,s Mobile MRI Unit – ... NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road to Early Detection ...
Breaking Medicine Technology: