Navigation Links
Lung stem cells vital to lung repair associated with poor cancer prognosis when found in tumor
Date:8/17/2010

Adult stem cells that are vital for airway repair in the lung but that persist in areas where pre-cancerous lesions are found are associated with a poor prognosis in patients who develop cancer, even those with early stage disease, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

These adult stem cells are found in repairing areas after injury and also are found in pre-cancerous areas, suggesting that these cells may mutate and become cancer causing stem cells, making them a potential cell-of-origin for lung cancer and a possible target for prevention strategies and new targeted therapies.

The study found that when these adult stem cells are found in excised tumors, they are associated with a poor prognosis and could be used as markers to dictate the need for more aggressive treatment for those patients, said Brigitte Gomperts, an assistant professor of hematology/oncology, a Jonsson Cancer Center researcher and co-senior author of the study.

The presence of the adult stem cells in the tumors also was found to be associated with a higher likelihood that the cancer had spread to other organs.

"We can use the presence of these adult stems cells to identify patients with a high likelihood of relapse and risk of the cancer spreading, even in those where the tumor is small and can be entirely removed," said Gomperts, who is also a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

The study appeared Aug. 15, 2010 in the peer-reviewed journal Cancer Research.

There is a growing body of evidence that shows many if not all cancers are caused by stem cells. Cancer stem cells are resistant to therapy and lie dormant, ramping up sometimes years later and recreating the tumor. If the cancer stem cells can be identified and studied, targeted therapies could be developed to kill them.

In this study, Gomperts and her team screened around 900 tumors removed from patients with non-small cell lung cancer at UCLA and MD Anderson Cancer Center, looking to see whether the adult stem cells could be found in the tumor. In her lab, Gomperts is now studying the pre-cancerous lesions where the adult stem cells persist in an attempt to uncover the cascade of molecular events that may transform these cells into lung cancer stem cells.

More than 222,000 Americans will be diagnosed with lung cancer this year alone. Of those, more than 157,000 will die, according to the American Cancer Society.

"Lung cancer is the leading cause of cancer death in the United States and is responsible for more deaths each year than breast, prostate, colon, liver, kidney and skin cancers combined. The overall five-year survival for lung cancer is only 15%, and this is mostly due to cancer recurrence and distant spread of the cancer," Gomperts said. "This fits nicely with the idea that adult stem cells in the lung that are normally involved in repair become cancer stem cells, which are resistant to our conventional therapies. Having a targeted therapy to use against these cancer stem cells may be the key to reducing mortality from this disease."


'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. Mayos smart adult stem cells repair hearts
2. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
3. Selected cells from blood or bone marrow may provide a route to healing blood vessels
4. Merlin protein found to control liver stem cells, prevent tumor development
5. Researchers develop magnetic molecular machines to deliver drugs to unhealthy cells
6. NIH award will enable design of brain tumor treatment that captures migrating cancer cells
7. Human embryonic stem cells purified in new, rapid technique
8. Caltech biologists discover microRNAs that control function of blood stem cells
9. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
10. CD74 serves as a survival receptor on colon epithelial cells
11. Effective inducing systems of hepatic differentiation from bone marrow mesenchymal stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... ... Charlotte health community, Queens University of Charlotte recently began recruitment efforts for the ... curriculum arms students with the skills, knowledge and expertise to approach and address ...
(Date:5/19/2017)... ... 2017 , ... Springfield, Vermont-based law firm of Brady/Callahan has released a new ... Hire An Experienced Personal Injury Attorney, " the article offers insight for people who ... article says. if someone is injured due to another person's negligence, they ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Arnold and Mabel ... , Victor Acosta, Ph.D. - University of New Mexico, Jeremy Baskin, Ph.D. - ... of Washington, Erik Grumstrup, Ph.D. - Montana Stata University, A. Fatih Sarioglu, Ph.D. ...
(Date:5/19/2017)... ... 2017 , ... ML Billing, 2016 Billing Company of the Year , ... large group practices, is pleased to announce their 30th anniversary. Not only has ML ... in all aspects of full-service medical billing. This has allowed ML Billing to excel ...
(Date:5/19/2017)... ... 18, 2017 , ... Somnoware, a leading provider of digital health technology, announces ... CPAP devices and supplies, such as machines, filters, tubing, and masks. Using this feature, ... registration for daily usage data is automated, and a DME order is created for ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... May 8, 2017 MACRA replaces the ... fee for service reimbursement. Black Book Research crowdsource-surveyed 8,845 ... 1.       The Market for MIPS Compliance Technology is ... physician practices with 3 or more clinicians seek to ... Q4. "Given the magnitude of the changes, the hunt ...
(Date:5/4/2017)... 4, 2017  Fortuna Fix Inc. (" Fortuna "), ... first to eliminate the need for embryonic and fetal stem ... neurodegenerative diseases. Fortuna announced today the ... Michael Fehlings , MD, PhD; Father Kevin FitzGerald , ... and Professor James Giordano , PhD. "We ...
(Date:5/4/2017)... 2017  A new tight-tolerance microextrusion medical tubing ... materials, is being launched by Natvar, a Tekni-Plex ... in recent years to service a wide variety ... More expensive materials such as glass and fluoropolymers ... to their ability to consistently hold tolerances. This ...
Breaking Medicine Technology: