Navigation Links
Lung disease may be genetic, despite lack of family history
Date:5/17/2010

ATS 2010 NEW ORLEANSPatients who encounter serious lung diseases in middle age, despite an absence of family history or other predisposing factors, may still have their genes to blame, according to a new study conducted by researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

The study also determined that the use of a simple screening test may help identify those genetic abnormalities and allow detection before the onset of disease.

"Earlier reports have indicated a correlation between certain nontuberculous mycobacterial respiratory infections and specific gene abnormalities," noted lead author Kenneth Olivier, M.D., M.P.H., NIAID staff clinician. "The results of this study confirm the correlation, and indicate the usefulness of simple testing in identifying these abnormalities, especially in an older population."

The results will be reported at the ATS 2010 International Conference in New Orleans.

The study of 32 patients focused on the movement of cilia, the tiny hair-like filaments that line the respiratory tract. In normal respiration, cilia help move dust and other fine particles out of the airway, keeping passages clear of harmful bacteria and other pathogens. When cilia are altered as the result of genetic mutation, they may fail to function properly, allowing disease-causing bacteria to build up.

"Genetic abnormalities in this clearance mechanism may predispose some older individuals to the development of certain pulmonary diseases, even though those individuals do not appear to have any predisposing factors," Dr. Olivier said.

Physicians can determine whether patients are at risk of the cilia not functioning correctly through a simple, noninvasive test that measures the levels of nitric oxide produced in the nose and sinuses. In patients who are predisposed to nontuberculous lung diseases, Dr. Olivier noted nitric oxide levels significantly lower than those of healthy individuals.

"Measurement of nasal nitric oxide production is easily performed, and can be an effective and noninvasive screen for identifying patients who may have abnormal ciliary function," he said. However, the screening test may also be abnormal for some patients with cystic fibrosis or acute viral respiratory infections, he added.

In patients with no known risk factors for lung disease, identifying which individuals are most likely to develop illness has posed a dilemma for physicians. Dr. Olivier said the results of this study may help researchers determine additional genetic abnormalities that could cause lung disease to develop, and may even lead to effective treatments.

"These results may lead to better understanding of predisposing genetic factors that will allow identification of at-risk individuals before the typical middle-age disease onset," he noted. "It may also allow development of preventive strategies or therapeutic interventions aimed at correcting airway clearance deficiencies."

"The next step is to focus on the identification of mutations in genes associated with ciliary dysfunction, to search for as yet unidentified novel cilia genes, and to utilize evolving technologies to better characterize genetic risks in patients with these diseases," he added.


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. New research identifies modifiable risk factors for heart disease
3. Distinct demographic profiles between Crohns disease and ulcerative colitis
4. Summit Medical Group hosts “Go Red Day” to Raise Awareness of Heart Disease and Stroke
5. Keenan Selects Nurtur and Healthyroads for Integrated Disease Management and Personal Wellness Programs
6. Michael J. Fox Foundation Awards $2.8 Million to Drive Development of Parkinsons Disease Biomarker Pipeline
7. Tests showing smokers their individual risk of future disease will help them quit, says paper
8. Researcher to track spread of disease, malware and power outages
9. Texas Health Dallas Launches Screening Program for Female Heart Disease
10. Hard to Treat Diseases (HTDS) Comments on Recent Movement Of Its Security
11. A better sign of blood vessel narrowing and early coronary artery disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... centers in the U.S., announced today its plans to open a flagship location in ... will occupy the former Rooms To Go store next to Office Depot in the ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
Breaking Medicine Technology: