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Lung changes are present in nearly half of ACPA positive RA patients at disease onset
Date:6/8/2012

an early stage."

This study followed 105 RA patients with symptom duration of less than one year at the time of diagnosis and nave to treatment with disease modifying anti-rheumatic drugs (DMARDs). A second non-RA cohort was matched for age, smoking status and gender.

The study demonstrates that HRCT abnormalities, shared citrullinated epitopes with the joints and local production of ACPA are present in the lungs of patients before the onset of RA, proposing that site-specific extra articular changes might be the initiating event of the specific immune response in ACPA positive RA.


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Contact: Candice Debleu
eularpressoffice@cohnwolfe.com
44-789-438-6425
European League Against Rheumatism
Source:Eurekalert

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