Navigation Links
Lung changes are present in nearly half of ACPA positive RA patients at disease onset

Berlin, Germany, June 8 2012: A new study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, shows that lung changes in association with anti-citrullinated protein autoantibody (ACPA) status are a primary manifestation of rheumatoid arthritis (RA).

Study findings show that 51% of RA patients (n=105) had identifiable lung changes (as measured by high resolution computer tomography [HRCT]) as compared to 28% of healthy controls (n=43). In addition, ACPA presence but not smoking status was associated with HRCT changes. This demonstrates that lung abnormalities are more frequent in RA patients as compared to individuals without RA, but with comparable age, smoking status, gender and geographic area.

Mass spectrometry identified five proteins in the synovium (eight sites in total) and four in the lungs (six sites in total) containing citrullinated residues. Two vimentin derived citrullinated peptides were present in a majority of both synovial and lung biopsies with higher citrullinated/unmodified peptide ratios in the smokers as compared to non-smokers. Additionally, there was a significant increase in expression of both peptydilamino deiminase (PAD) 2 and PAD4 enzymes in the lungs of current smokers, independent of the ACPA status.

"Our finding suggests an active involvement of the lungs in the initiation phase of chronic inflammatory joint disease. Interestingly, these abnormalities were mainly restricted to those RA patients who were positive for ACPA, as well as smokers," said Dr. Anca Catrina, from the Department of Medicine, Karolinska Institute, Sweden and lead study author. "We believe that there is an urgent need for more active screening to identify lung disease in high risk RA patients (especially ACPA positive smokers). Anti-smoking strategies as part of RA treatment programs and further interventional studies are needed in order to mediate the local immune process in the lungs at an early stage."

This study followed 105 RA patients with symptom duration of less than one year at the time of diagnosis and nave to treatment with disease modifying anti-rheumatic drugs (DMARDs). A second non-RA cohort was matched for age, smoking status and gender.

The study demonstrates that HRCT abnormalities, shared citrullinated epitopes with the joints and local production of ACPA are present in the lungs of patients before the onset of RA, proposing that site-specific extra articular changes might be the initiating event of the specific immune response in ACPA positive RA.


Contact: Candice Debleu
European League Against Rheumatism

Related medicine news :

1. VCU researchers identify changes in cholesterol metabolic pathways
2. First study to suggest that the immune system may protect against Alzheimers changes in humans
3. Tiny Tots in the Dentists Chair Among Changes in Pediatric Dentistry
4. From One Generation to the Next, Dental Care Changes
5. Eye Changes May Predict Heart Disease in Blacks With Diabetes
6. Chronic cocaine use triggers changes in brains neuron structure
7. Palliative care resource helps ease changes
8. Dietary changes help some children with ADHD
9. Molecular probes identify changes in fibronectin that may lead to disease
10. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
11. Brain Changes May Hamper Decision-Making in Old Age
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ... Secura Consultants has prided itself for not only fulfilling the needs of advisers ... solutions at an affordable price and providing top-tier customer service. However, there's always ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... CBD ... Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography ... CAAHEP accredited colleges, as only one of twelve colleges and universities in the state ...
(Date:11/27/2015)... Santa Rosa, CA (PRWEB) , ... November 27, 2015 , ... ... Northern California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine ... dinner meeting. They observed that both STEMI and Sepsis conditions present in similar ways ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft ... announces the incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite ... LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that will receive ...
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think ... customers choose to buy during the Black Friday and Cyber Monday massage chair ... to search the Internet high and low to find the best massage chair deals, ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Monitoring (TDM) Market: Supplier Shares, Country ...  report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Cell Surface Marker ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
Breaking Medicine Technology: