Navigation Links
Lung cancer survival rates improved through use of individualized chemotherapy
Date:8/31/2010

Chemotherapy is the best broad defense against cancer recurrence after surgical resection. However, it is difficult to predict which patients will benefit from which regimen of anticancer drugs, if at all. Building on existing knowledge, a study published in the September edition of the Journal of Thoracic Oncology (JTO), analyzed the usefulness of adjuvant chemotherapy for non-small cell lung cancer (NSCLC) based on the histoculture drug response assay (HDRA). After seven years of study, researchers concluded that the use of adjuvant (post-operative) chemotherapy based on results of the in vitro HDRA improved the survival and prognosis of patients with NSCLC who had undergone surgery and whose results of the HDRA assay showed chemosensitivity to the specific drugs used for treatment.

The patients' chemosensitivity to cisplatin, carboplatin, paclitaxel, docetaxel, gemcitabine and irinotecan were examined by the HDRA assay. The patients in the study were then split into two groups: (1) those whose tumors were sensitive to at least two of the HDRA drugs and received two HDRA positive drugs per chemotherapy session (31 patients) and (2) those whose tumors were sensitive to one or none of the HDRA drugs and were treated with a combination of one HDRA positive drug and one HDRA negative or two HDRA negative drugs per chemotherapy session (34 patients).

The overall five-year survival rate for the prediction sensitive group given two HDRA positive drugs was 82.4 percent. In contrast, the five-year survival rate for the patients whose tumors indicated a low sensitivity or no sensitivity to the HDRA drugs and received one HDRA positive drug and one HDRA negative or two HDRA negative drugs was 40.1 percent. Additionally, the rate of relapse was lower for the patients in the prediction sensitive group. Relapse occurred in 29 percent of patients who were given two HDRA positive drugs per chemotherapy session while it occurred in 55.8 percent of pa
'/>"/>

Contact: Colleen Butz
cbutz@spectrumscience.com
202-587-2557
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Tumor budding identified as predictor for unfavorable outcome in lung cancer
2. Preventive cancer surgeries save womens lives
3. Can Fruits, Veggies Help Ward Off Lung Cancer?
4. Increasing selenium intake may decrease bladder cancer risk
5. Diverse diet of veggies may decrease lung cancer risk
6. Moderate Drinking May Boost Risk of Breast Cancers Return
7. Use the common cold virus to target and disrupt cancer cells?
8. Double-therapy approach effectively inhibited brain cancer recurrence
9. New nuclear breast imaging technologies associated with higher cancer risks
10. Alcohol intake increases certain types of breast cancer
11. Nicotine binding to receptor linked to breast cancer cell growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- Overeating is common ... you eat in moderation, an expert says. "Don,t arrive ... up calories if you know you,ll be attending a party, ... Jill Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount ... better to eat healthy during the day and even to ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 “ SmileStix ” ... which features the latest and coolest mobile applications on the ... expert and host of NewsWatch, conducted the app review and ... to create personal stickers. , The old saying goes, “A ... lot of words that can describe a single image, because ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those ... During the holiday season, AlignLife looks forward to their annual ... Dr. Sara Mahalko-Leonhardt, owner of AlignLife. "It brings our patients ... we are able to give kids toys for Christmas who ... the generosity of our patients." , The 70 toys were ...
(Date:12/24/2014)... December 24, 2014 Risperdal lawsuit ( ... mass tort litigation currently underway in Pennsylvania’s Philadelphia Court ... of December 24, 2014, court documents indicate that 1,183 ... of individuals who developed gynecomastia (male breast growth) and ... the Court indicates that this represents an increase of ...
(Date:12/24/2014)... December 25, 2014 Today, Yunx.co.uk, a ... evening dresses and other special occasion outfits, unveils ... models are offered at discounted prices, up to 80% ... young ladies with their fashionable designs, gorgeous looks and ... exception. The business is devoted to designing and offering ...
Breaking Medicine News(10 mins):Health News:An Application to Create Custom Stickers was Featured on NewsWatch Television on December 19, 2014 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Yunx.co.uk Unveils 65 New Bridesmaid Dresses for the UK market 2
... radar of the immune system is by using IDO, an ... powerful regulatory T cells that turn down the immune response, ... barrier of regulatory T cells, or Tregs, but how ... David Munn, pediatric hematologist/oncologist at the Medical College of Georgia ...
... discovered a new protein that may offer fresh insights into ... defined a second prion protein called Shadoo, that exists in ... Professor David Westaway, director of the Centre for Prions and ... decades we believed PrP was a unique nerve protein that ...
... University of Sheffield in the UK and Leibniz Institute for ... that female hyenas avoid inbreeding with their male relatives by ... , Animals generally avoid inbreeding because it is genetically ... home or, like humans, by learning who their relatives are ...
... exposed to higher levels of air pollution show marked ... short-term breathing problems, according to researchers in Mexico. , ... in children with long-term exposure to air pollutants, wrote ... "In addition to the important impact of lung health, ...
... study to use brain imaging to look at the ... depression, researchers at the University of Wisconsin-Madison have found ... differently than those of healthy people when trying to ... Health Organization, clinical depression is one of the leading ...
... infection, use of the HPV-16/18 vaccine will not accelerate reduction ... the infection, according to a study in the August 15 ... HPV infection and the development of cervical precancers and cancer. ... the virus in women already infected, according to background information ...
Cached Medicine News:Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 2Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 3Health News:Tumors use enzyme to recruit regulatory T-cells and suppress immune response 4Health News:New prion protein discovered by Canadian scientists may offer insight into mad cow disease 2Health News:Females avoid incest by causing male relatives to leave home 2Health News:High pollution linked to poor lung function growth in children in Mexico City 2Health News:Clinical depression linked to abnormal emotional brain circuits 2Health News:Clinical depression linked to abnormal emotional brain circuits 3Health News:HPV vaccine does not appear to be effective for treating pre-existing HPV infection 2Health News:HPV vaccine does not appear to be effective for treating pre-existing HPV infection 3
(Date:12/24/2014)... SCHOFIELD, Wis. , Dec. 23, 2014 ... and marketer of over-the-counter (OTC) medicinal and healthcare products, ... production of MigraPure® H, a hemp-based, advanced headache relief ... marijuana dispensaries in Colorado , ... . With the MigraPure H Advanced ...
(Date:12/24/2014)... LEXINGTON, Mass. , Dec. 23, 2014 /PRNewswire/ ... GEVA ), a biopharmaceutical company developing therapeutic products ... European Medicines Agency (EMA) of the Marketing Authorization ... The EMA recently granted the company,s request for ... the EMA,s regulatory review time.   ...
(Date:12/24/2014)... Calif. , Dec. 23, 2014 In response ... Doctors, Association of Sierra Leone , Direct ... Leone for the treatment of local health workers ... While a new dedicated Ebola care center was constructed for ... the facility is not available for local Sierra Leonean health ...
Breaking Medicine Technology:PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2
... 2011 Aoxing Pharmaceutical (NYSE Amex: ... focusing on research, development, manufacturing and distribution of ... subsidiary in China, Hebei Aoxing Pharmaceutical Group Company, ... Intellectual Property Office of The People,s Republic of ...
... 2011 IRIDEX Corporation (Nasdaq: IRIX ) ... had issued to IRIDEX a patent applying to a ... ophthalmic surgical procedures. The patent, No. 7,909,816 and titled ... consumable medical devices already in the IRIDEX product line ...
Cached Medicine Technology:Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 2Aoxing Pharmaceutical Company Announces Issuance of Chinese Patent for Naloxone Sublingual Film 3IRIDEX Granted U.S. Patent for Stepped Angled Laser Handpieces Used in Eye Surgery 2IRIDEX Granted U.S. Patent for Stepped Angled Laser Handpieces Used in Eye Surgery 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: