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Lung cancer study hints at new treatments
Date:7/9/2014

r time to see how the tumor cells escape, inhibiting one pathway and becoming resistant to therapies."

The researchers also found other relevant mutations in important genes such as EGFR, NF1, NF2 and MET. Such findings could be valuable to a clinical trial known as ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial) that Govindan is leading. The trial will involve the screening of tumors from several thousand lung cancer patients for alterations in genes called EGFR and ALK. After surgery to remove their tumors, these patients will be invited to participate in clinical trials studying drugs targeting these dysfunctional genes.

The ALCHEMIST trial builds on the current study and also potentially will provide additional tumor samples for genomic analysis. A large sample size is important in accurately identifying mutations driving lung tumor growth.

"Patients with lung cancer often have substantial tobacco exposure, which leads to a lot of mutations," Govindan said. "We may not be able to find significant mutations unless we study multiple samples from several thousand patients."

Despite such progress in understanding lung cancer the most common cause of cancer deaths worldwide the investigators emphasize that the best way to reduce lung cancer deaths is to help people stop smoking and encourage others to never start.


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Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

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