Navigation Links
Lung cancer study hints at new treatments
Date:7/9/2014

Studying the most common type of lung cancer, researchers have uncovered mutations in a cell-signaling pathway that plays a role in forming tumors. The new knowledge may expand treatments for patients because drugs targeting some of these genetic changes already are available or are in clinical trials.

Reporting July 9 in Nature, investigators from The Cancer Genome Atlas (TCGA), including researchers at Washington University School of Medicine in St. Louis, Harvard Medical School and other institutions, studied tumors from 230 patients with lung adenocarcinoma.

"This is the first time we have had a panoramic look at the genomic landscape of this many lung tumor specimens," said oncologist Ramaswamy Govindan, MD, professor of medicine at Washington University and TCGA lung cancer project co-chair. "These studies reinforce the opinion that lung cancer is a very heterogeneous disease."

Combined with an earlier study of 178 patients with lung squamous cell carcinoma, TCGA researchers now have published genetic data on about 400 lung cancer patients and are working to analyze tumors from 600 more. The investigators included scientists at The Genome Institute at Washington University and other major sequencing centers.

In the new study, among the myriad genetic changes observed in adenocarcinoma, one cell-signaling pathway stood out. About 75 percent of the samples had mutations that overactivated a pathway called RTK/RAS/RAF, known for roles in tumor growth.

"It is remarkable how important the RTK/RAS/RAF pathway appears to be," said Govindan, who treats patients at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine. "Mutations in this particular pathway promote cancer cell proliferation. What is amazing is how many ways this pathway can be activated.

"We also know these tumors are not static," he added. "They evolve. We have to be looking at multiple biopsies ove
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses
2. MyChart use skyrocketing among cancer patients, UT Southwestern study finds
3. A possible pathway for inhibiting liver and colon cancer is found
4. Low doses of arsenic cause cancer in male mice
5. Support team aiding caregivers of cancer patients shows success, CWRU researchers report
6. Does cycling increase risk for erectile dysfunction, infertility, or prostate cancer?
7. Concern at lack of teenage patients in cancer trials
8. NUS researchers discover novel protein complex with potential to combat gastric cancer
9. First cancer immunotherapy for dogs developed
10. Association found between high cholesterol and breast cancer
11. Upending a cancer dogma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Angeles, CA (PRWEB) September 22, 2014 ... training course from Winter & Alvin has just ... of excitement throughout the personal development community. The ... the attention of HonestyFirstReviews.com's Tiffany Hendricks prompting an ... a topic of great interest for many entrepreneurs ...
(Date:9/22/2014)... 22, 2014 The professional review ... many professional WordPress hosting companies and announced that ... are the best WordPress hosting suppliers for webmasters ... (including VPS and cloud hosting) at affordable rates. ... says, “We're sure that our customers will find ...
(Date:9/22/2014)... Downers Grove, IL (PRWEB) September 22, 2014 ... a complimentary webinar titled "From Divorce Talk to Solution ... of Couples Sessions.” The 60-minute webinar, presented by special ... September 24th, at 1pm Central Standard Time. , ... Divorce Talk to Solution Talk: Solution Focused Brief Therapy ...
(Date:9/22/2014)... Mississauga, Ontario (PRWEB) September 22, 2014 ... August 1st, 2014 at the PWN International Conference in ... Canadian release that was celebrated with a reception attended ... this reception Dawn shared insights she had gained while ... organizational side of the glass ceiling issue, and what ...
(Date:9/21/2014)... Santa Clara, CA (PRWEB) September 22, 2014 ... 2.0 conference it has entered into a joint services ... in South Dakota, to deploy the CareSpan Virtual Clinic ... CareSpan and Avera eCARE plan to deploy their joint ... South Dakota and Wyoming where Avera eCARE is licensed. ...
Breaking Medicine News(10 mins):Health News:"The Millionaire's Brain" - A Review Examining Winter & Alvin's Training Course Released 2Health News:TherapySites Presents a Webinar, "From Divorce Talk to Solution Talk: Solution Focused Brief Therapy with the Most Trying of Couples Sessions” with Elliott Connie 2Health News:TherapySites Presents a Webinar, "From Divorce Talk to Solution Talk: Solution Focused Brief Therapy with the Most Trying of Couples Sessions” with Elliott Connie 3Health News:Ruby Report Book Launch Reveals Critical Insights on Gender Intelligence 2Health News:Avera eCARE and CareSpan form Collaboration to Deliver “Virtualized” Primary Care in the Dakotas and Wyoming 2Health News:Avera eCARE and CareSpan form Collaboration to Deliver “Virtualized” Primary Care in the Dakotas and Wyoming 3
... ... is a Leading Cause of Chronic Pain and Disability in U.S. , ... Belleville, Ill. (Vocus) May 3, ... make fibromyalgia visible by increasing awareness and understanding during Fibromyalgia Awareness Day on May ...
... treated in an emergency department (ED) after being assaulted, ... another violent encounter soon afterward, according to a study ... Societies (PAS) annual meeting in Vancouver, British Columbia, Canada. ... growing up in urban environments, and many emergency departments ...
... Center study of 2,500 patient records suggests that medical ... fifth of the time, and is not recognizing what ... they do check., Researchers at Hopkins Children,s say the ... the development of hypertension and its serious consequences, even ...
... LA (May 2, 2010) Non-alcoholic fatty liver disease ... liver transplant, is found to be significantly associated with ... diagnosing NAFLD represents an alternative to liver biopsy, which ... and alfafeprotein blood test screening are an effective alternative ...
... Scientists have discovered three genes linked to the development of ... one million people in the UK. The international ... the genes are involved in regulating the rate at which ... might occur. Paget,s disease disrupts the body,s normal ...
... be on the right side, requiring colonoscopy for detection, study says ... twice as likely as women to have colon polyps and are ... Puerto Rico has found. , The researchers also found that the ... have polyps than those younger than 60. , Polyps are growths ...
Cached Medicine News:Health News:Make Fibromyalgia Visible May 12 2Health News:Make Fibromyalgia Visible May 12 3Health News:Young assault victims often involved in subsequent violence 2Health News:Despite tests, high blood pressure hard to recognize in children 2Health News:Despite tests, high blood pressure hard to recognize in children 3Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 2Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 3Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 4Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 5Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 6Health News:Researchers make advances in understanding causes, treatments and outcomes of liver disease 7Health News:Gene find offers hope of screening test for bone disease 2Health News:Colon Polyps More Common in Hispanic Men Than Women 2
(Date:9/19/2014)... CHICAGO , Sept. 19, 2014  4WEB Medical ... of 3D-printed foot and ankle osteotomy implants on ... and Ankle Society annual meeting in Chicago ... for all of a surgeon,s osteotomy needs with 74 size ... wedge systems had smaller offerings of only 15 to 18 ...
(Date:9/19/2014)... Sept. 19, 2014 Merck (NYSE: MRK ), ... and Canada , is teaming with celebrity chef ... Logra Tus Metas , an educational program encouraging Hispanics with type ... a key treatment goal to help reduce the risk of serious ... are at a higher risk for developing type 2 diabetes than ...
(Date:9/19/2014)... Sept. 19, 2014  Diplomat, the nation,s largest independent ... Dreyer to the Board of Directors on September ... will also serve as chair of the Audit Committee. ... of accounting, financial, compliance and operating experience in the ... served as chief financial officer, chief operating officer and ...
Breaking Medicine Technology:4WEB Medical Unveils 3D-Printed Osteotomy Truss System 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5David Dreyer Appointed to Diplomat Board of Directors 2
The CD Horizon M10 Spinal System provide spine surgeons comprehensive solutions for the treatment of spinal deformities, trauma reconstruction, and degenerative conditions....
... VIASYS Neurocare - continues the ... diagnosis. Exceptional convenience and speed. Superior ... ,VasoGuard delivers features you won't find ... for cuff attachment and testing. Up ...
... Spine System Evolution offers the latest ... variety of spinal pathologies including degenerative lumbar ... It is also intended for the treaent ... of the L5-S1 vertebra. Levels of pedicle ...
Multiwindow transcranial and peripheral Doppler system....
Medicine Products: