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Lung cancer screening trial shows screening with CT scans reduces lung cancer deaths
Date:6/29/2011

hasizes, "Given the considerable costs associated with low-dose helical CT screening, a cost-effectiveness analysis using the NLST data is underway that will guide decisions about the best use of finite health care resources."

The NLST also provided a unique opportunity to advance investigation of molecular biomarkers for the early detection of lung cancer. Specimens of blood, sputum and urine collected at ACRIN sites are banked in the NLST-ACRIN Biorepository, as are specimens of early-stage lung cancer, all obtained with consent from NLST participants. This resource is available to the larger research community. "These specimens provide a rich resource to validate molecular markers that may complement imaging to detect early lung cancer," says Aberle. "By coupling biospecimen collection with imaging-based screening, the NLST-ACRIN Biorepository is relatively enriched for early clinical-stage lung cancers and associated biospecimens, and provides a unique resource of extremely well-characterized biospecimens with longitudinal data."

"The knowledge that low-dose CT is a viable screening tool for detecting lung cancers at a curable stage is a tremendous first step for better understanding its implications for clinical care. Working with the Eastern Cooperative Oncology Group through the recently announced alliance, will allow us to extend these significant results to answer future questions critical for translating today's findings into clinical practice," says Mitchell D. Schnall, M.D., Ph.D., ACRIN's network chair and the Matthew J. Wilson Professor of Research Radiology at the University of Pennsylvania. "Furthermore, ACRIN is engaged in a research project with Boston University funded by the United States Department of Defense to investigate the role of blood and sputum-based laboratory tests to better define patient populations who would most benefit from lung cancer screening and, thereby, reducing false-positive screenings."


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Contact: Shawn Farley
PR@acr.org
703-648-8936
American College of Radiology
Source:Eurekalert

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