Philadelphia Results of the National Lung Screening Trial (NLST) published online in the June 30 New England Journal of Medicine report a twenty percent reduction in lung cancer deaths among study participants who were screened with low-dose helical computed tomography (CT) versus those screened with chest X-ray. Conducted by the American College of Radiology Imaging Network (ACRIN) and the National Cancer Institute's Lung Screening Study Group, the NLST enrolled 53,000 current and former heavy smokers aged 55 to 74 at 33 sites across the United States.
Lung cancer is the leading cause of cancer-related deaths in the United States, with more than 94 million current or former smokers at elevated risk of the disease. Most lung cancers are detected when they cause symptoms, by which time the disease is more likely to be advanced and less curable.
"The trial results published today provide hard evidence of the mortality benefit from low-dose helical CT screening for lung cancer in an older and heavy smoker population. These findings, and the vast amount of additional data generated by the NLST that are still being studied, offer a rich resource of information that will inform the development of clinical guidelines and policy recommendations," states Denise R. Aberle, M.D., the national principal investigator for NLST ACRIN, a deputy co-chair of ACRIN, professor of radiology and bioengineering and vice chair for research in Radiological Sciences at UCLA.
The nearly decade-long trial, sponsored by the National Cancer Institute, a part of the National Institutes of Health, enrolled participants over a 20-month period who were randomly assigned to receive three annual screening examinations with either low-dose helical CT or standard chest X-ray.
The paper published today provides important details about the number of screens that identified abnormalities potentially related to lung cancer and how many abnormalities were ult
|Contact: Shawn Farley|
American College of Radiology