Navigation Links
Lung cancer risk increases with expression of specific genes
Date:10/1/2009

AURORA, COLO A recent study published in the October 2009 issue of the Journal of Thoracic Oncology determined that variations of specific genetic markers identified in previous research, or SNPs, may indicate a greater lung cancer risk in African Americans than in whites. The genes CHRNA3 and CHRNA5 may contribute to lung cancer risk due directly or through their association with nicotine dependence. Although their presence is less frequent in African Americans, the risk for lung cancer may be greater when present.

Researchers from the Karmanos Cancer Institute in Detroit, MI and the MD Anderson Cancer Center in Houston, TX evaluated data on 1,508 non-small cell lung cancer(NSCLC) patients (38 percent of which were African American) selected from the Detroit SEER Cancer registry and 1,314 corresponding control patients matched based on age, gender and race. The three case-controlled studies examined family history of lung cancer, smoking history, and age. Using unconditional logistical regression, a type of statistical analysis, researchers identified associations between SNPs and lung cancer risk while controlling for age, sex and smoking behavior.

Despite reporting lower levels of smoking, lung cancer incidence remains higher for African Americans, than for whites, so this is an important population in which to study the role of CHRNA3 and CHRNA5 genes and risk of lung cancer.

Previous conclusions from the genome-wide associates studies (GWAS) identified associations between NSCLC risk, smoking behaviors and SNPs on the chromosome 15q25.1. The present study concentrated on the genes CHRNA3 and CHRNA5, confirming a stronger association with the risk of lung cancer than with nicotine dependence in African Americans.

"This research confirms that differences on a genetic level can alter our risks for lung cancer," said lead investigator Ann Schwartz. "This research extends the need for such discoveries across diverse populations."


'/>"/>

Contact: Megan Richter
mrichter@spectrumscience.com
202-587-2556
International Association for the Study of Lung Cancer
Source:Eurekalert

Related medicine news :

1. Molecular imaging holds promise for early intervention in common uterine cancer
2. Recent, vigorous exercise is associated with reduced breast cancer risk
3. PLCB, PA Breast Cancer Coalition, Beringer Wine Partner To Support Breast Cancer Awareness
4. Anchor Bay Entertainment Joins Forces With Susan G. Komen for the Cure(R) in the Fight Against Breast Cancer
5. Lack of Social Interaction Affects Health Outcomes of Breast Cancer --Stress from loneliness leads to increased tumor growth, Decrease breast cancer risk by increasing social interaction
6. Non-AIDS-Related Cancers Growing Among HIV Patients
7. Polaroid(R) and The Breast Cancer Research Foundation(R) Print Pink
8. A potential new imaging agent for early diagnosis of most serious skin cancer
9. UCSF Announces Expanded BreastCancerTrials.org Website
10. Ann Taylor Supports The Fight Against Breast Cancer
11. Breast Cancer Death Rates Continue to Drop 2% Annually
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the ... “America On The Brink” is the creation of published author, William Nowers. Captain ... As a WWII veteran, he spent thirty years in the Navy. Following his ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the ... a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, ... retirement havens have extremely low property-tax rates, which contributes to the relatively lower ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017  NDS received FDA 510(k) clearance ... a medical-grade battery-powered display stand specifically designed for endoscopy environments. An ... technology into a clinical solution to support the improvement of patient ... Innovative Design ... Wireless Solution ...
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
Breaking Medicine Technology: