Navigation Links
Lung cancer risk increases with expression of specific genes
Date:10/1/2009

AURORA, COLO A recent study published in the October 2009 issue of the Journal of Thoracic Oncology determined that variations of specific genetic markers identified in previous research, or SNPs, may indicate a greater lung cancer risk in African Americans than in whites. The genes CHRNA3 and CHRNA5 may contribute to lung cancer risk due directly or through their association with nicotine dependence. Although their presence is less frequent in African Americans, the risk for lung cancer may be greater when present.

Researchers from the Karmanos Cancer Institute in Detroit, MI and the MD Anderson Cancer Center in Houston, TX evaluated data on 1,508 non-small cell lung cancer(NSCLC) patients (38 percent of which were African American) selected from the Detroit SEER Cancer registry and 1,314 corresponding control patients matched based on age, gender and race. The three case-controlled studies examined family history of lung cancer, smoking history, and age. Using unconditional logistical regression, a type of statistical analysis, researchers identified associations between SNPs and lung cancer risk while controlling for age, sex and smoking behavior.

Despite reporting lower levels of smoking, lung cancer incidence remains higher for African Americans, than for whites, so this is an important population in which to study the role of CHRNA3 and CHRNA5 genes and risk of lung cancer.

Previous conclusions from the genome-wide associates studies (GWAS) identified associations between NSCLC risk, smoking behaviors and SNPs on the chromosome 15q25.1. The present study concentrated on the genes CHRNA3 and CHRNA5, confirming a stronger association with the risk of lung cancer than with nicotine dependence in African Americans.

"This research confirms that differences on a genetic level can alter our risks for lung cancer," said lead investigator Ann Schwartz. "This research extends the need for such discoveries across
'/>"/>

Contact: Megan Richter
mrichter@spectrumscience.com
202-587-2556
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular imaging holds promise for early intervention in common uterine cancer
2. Recent, vigorous exercise is associated with reduced breast cancer risk
3. PLCB, PA Breast Cancer Coalition, Beringer Wine Partner To Support Breast Cancer Awareness
4. Anchor Bay Entertainment Joins Forces With Susan G. Komen for the Cure(R) in the Fight Against Breast Cancer
5. Lack of Social Interaction Affects Health Outcomes of Breast Cancer --Stress from loneliness leads to increased tumor growth, Decrease breast cancer risk by increasing social interaction
6. Non-AIDS-Related Cancers Growing Among HIV Patients
7. Polaroid(R) and The Breast Cancer Research Foundation(R) Print Pink
8. A potential new imaging agent for early diagnosis of most serious skin cancer
9. UCSF Announces Expanded BreastCancerTrials.org Website
10. Ann Taylor Supports The Fight Against Breast Cancer
11. Breast Cancer Death Rates Continue to Drop 2% Annually
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... AZ (PRWEB) August 30, 2014 Hastings ... personal injury attorneys located throughout Arizona is pleased to ... This is one specific example among many cases where ... clients are able to retain a greater portion of ... after case that providing a positive solution for Arizona ...
(Date:8/30/2014)... August 30, 2014 Serving contented clients ... India, Profit By Outsourcing is now offering discount ... The company gives emphasize on putting forward the best ... to clients. Their dedicated team of professionals and web ... They can handle even the critical issues of web ...
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Removecomplaints.net, a ... management industry, has announced to offer guarantee of results ... to offer this guarantee because of its tremendous track ... 200 clients from all over the world and received ... good job. , On being asked about the ...
(Date:8/30/2014)... 30, 2014 When a prominent bank reveals ... happened on Wednesday, August 27th, when news began surfacing about ... Chase & Co and at least one other bank. ... investigating attacks on seven prominent banks , everyone starts ... affected, and the buzz quickly goes viral. Bloomberg followed ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Removecomplaints.net Announces Guaranteed Complaints Removal Services 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5
... out of Wake Forest Baptist Medical Center reveal that a common ... diabetes. The study appears in the May ... already at high risk of developing heart disease and experiencing an ... Center for Diabetes Research at Wake Forest Baptist and lead investigator. ...
... 2011 Gothenburg, Sweden: Two trials presented at the Heart Failure ... of the European Society of Cardiology (HFA of the ESC), ... chronic heart failure (CHF) in whom telemedical management ... presented in Late Breaking Session 1 - revealed that telemonitoring ...
... , SATURDAY, May 21 (HealthDay News) -- As ... of heat-related illnesses, experts say. "We are not ... said Brendon McDermott, an athletic trainer with the University ... Stringer Institute (KSI) Medical and Science Advisory Board, in ...
... American Federation for Aging Research (AFAR) today announced $2.5 million ... faculty at 27 Centers of Excellence in Geriatric Medicine and ... from the John A. Hartford Foundation, has to date, granted ... leaders in geriatrics. As our nation ages, we need these ...
... discs in the low back wear out, become compressed and ... discs can be a viable alternative to standard fusion surgery, ... recently published in the Journal of Bone and Joint ... fusion but this is believed the first to evaluate the ...
... during childhood have a significantly higher risk of developing gastrointestinal ... life, according to a study led by the University of ... cancer survivors and their physicians to be aware of these ... met. "We have, in a relatively short period of ...
Cached Medicine News:Health News:Common test could help predict early death in diabetes, study shows 2Health News:Common test could help predict early death in diabetes, study shows 3Health News:Telemonitoring can improve overall survival of HF patients 2Health News:Telemonitoring can improve overall survival of HF patients 3Health News:Telemonitoring can improve overall survival of HF patients 4Health News:Telemonitoring can improve overall survival of HF patients 5Health News:Keeping Cool in the Heat 2Health News:AFAR announces the 2011 Hartford Scholars in Geriatric Medicine 2Health News:2-year results: Artificial disc a viable alternative to fusion for 2-level disc disease 2Health News:Childhood cancer survivors at higher risk for future GI complications 2
(Date:8/29/2014)... HILL, N.C. , Aug. 29, 2014 ... face of regulatory and marketplace changes. CI leaders who ... In a new Best Practices, LLC ... host of actionable insights, including: - Use ... cheaper than primary research - Internal staff ...
(Date:8/29/2014)... 29, 2014  A Boston Scientific Corporation (NYSE: ... stent removability and preliminary long term stricture resolution ... the August issue of the peer-reviewed journal, Gastroenterology. ... is being conducted in 11 countries and five ... metal stents (FCSEMS) after extended indwell (i.e., up ...
(Date:8/29/2014)... Thoratec Corporation (NASDAQ: THOR ), ... to save, support and restore failing hearts, said today ... Global Healthcare Conference on Wednesday, September 10. ... Officer, will provide an update on the company, beginning ... Daylight Time).   A webcast of the ...
Breaking Medicine Technology:Using the Competitive Intelligence Function to Drive Better Business Decisions in the Pharmaceutical Sector 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... Corkscrew Parachute Tissue Anchor allows one step fixation ... ideal for arthroscopic knotless rotator cuff repair in ... has an outside thread diameter of 5 mm ... #2 FiberWire suspension sutures securely hold a thin, ...
... with needles are also available for use when ... the suture comes with a 26 mm 1/2 ... a trap door on the inserter handle.,The punch ... the implant is inserted. In hard bone, the ...
... can be used as an adjunct to ... apposition to bone to speed healing and ... fixation forces over a greater area dramatically ... mm thick disc of bioabsorbable PLLA has ...
... generation of polyester suture with a long ... than similar sized polyester suture with superior ... profile. FiberWire is the ideal suture for ... suture breakage during knot tying.,All sizes of ...
Medicine Products: