Navigation Links
Lung cancer research team awarded $1.43 million to study cancer in Eastern Kentucky
Date:9/22/2011

LEXINGTON, Ky. (Sept. 22, 2011) - The University of Kentucky's Dr. Susanne Arnold and colleagues were awarded a grant by the Department of Defense to study potential environmental reasons for the high lung cancer rates in Eastern Kentucky. The grant is for $1.43 million over three years and the study began on Sept. 15.

Kentucky has the highest lung cancer rates in the nation, but counties in the southeastern portion of the state those in the 5th Congressional District have an exceptionally high incidence of lung cancer. Data from the Kentucky Cancer Registry, a Surveillance, Epidemiology and End Result (SEER) site, revealed that the age-adjusted incidence rate for lung cancer in Appalachian Kentucky from 2003-2007 was 115.2 cases per 100,000 residents, compared to 61.6 cases per 100,000 residents nationally.

A "high" lung cancer rate is defined as more than 101.6 cases per 100,000 residents. By this definition, 83 percent of the counties in the 5th District have high rates, compared to 38 percent for the rest of Kentucky.

Tobacco use is the leading cause of lung cancer, and 25 percent of Kentuckians smoke, compared to the 21 percent of people nationally. But smoking on its own doesn't explain the discrepancy between southeastern Kentucky and the rest of the nation, said Arnold.

"We know that tobacco is the number one cause of lung cancer, but that isn't the only factor causing the high cancer burden for southeastern Kentucky," Arnold says. "So we started to look for other possible reasons. Could environmental carcinogens play a role? That's what this grant will allow us to investigate."

Arnold says the idea for the lung cancer study came about because of preliminary data from a study of colon cancer patients in Appalachia. The study examined toenail clippings from patients to assess their exposure to trace elements. Appalachian colon cancer patients showed significantly higher amounts of arsenic, chromium and nickel than non-Appalachian patients, suggesting that they had been exposed to these trace elements more extensively.

Although trace amounts of metals (such as iron) are necessary for the body's normal functions, prolonged exposure to trace elements including arsenic, beryllium, cadmium, cobalt, chromium, nickel and vanadium has been linked to several types of cancer including lung cancer. These trace elements are known to promote carcinogenesis by increasing oxidative stress, inflammation and DNA damage, and reduced DNA repair efficiency.

There are several potential sources for trace element exposure in southeastern Kentucky. Residents could be exposed through their water source, their soil, the local food sources they eat, or in other unknown ways.

Arnold says her study will define age- and gender-matched cancerous and non-cancerous residents. Each participant will be asked to fill out a questionnaire about his or her smoking habits. Researchers will determine the amount of exposure to trace elements by taking samples of residents' toenails, hair, urine and blood. To determine the source of the exposure, they'll also collect samples of water and soil from the home. The biological and environmental samples generated from this study will also be made available to other researchers to use for other studies on health in Appalachia.

This project is also partnering with Kentucky Homeplace, an advocacy organization known and trusted throughout southeastern Kentucky. The organization provides access to medical, social, and environmental services for the citizens of the Commonwealth.

"We are extremely lucky to have this outstanding organization helping with this important initiative," Arnold said. "They will play a crucial role in helping us collect our data."

Arnold also spearheads the Marty Driesler 5th District Cancer Project, a rural health care initiative dedicated to increasing the survival rates for people with deadly cancers through out Kentucky's 5th Congressional District. The project encourages partnerships of the Markey Cancer Center and community health care providers and facilities to establish a community program for early detection, prevention, and treatment of lung, liver and esophageal cancer.

"As an eighth-generation Kentuckian, this work is really personal for me," Arnold said. "I was raised by a doctor who committed his life to research in Kentucky because he really believed it was important for us to help solve Kentucky's problems. And now I am a doctor that takes care of lung cancer in Kentucky. I feel like it's our job to be a champion for the people of Appalachia. I hope this study will help us to understand the epidemic that is ravaging southeastern Kentucky and begin to find solutions to this devastating problem."


'/>"/>

Contact: Allison Perry
allison.perry@uky.edu
859-323-2399
University of Kentucky
Source:Eurekalert  

Related medicine news :

1. TGen-Virginia G. Piper Cancer Center launches clinical trial for drug to treat lung cancer
2. New Test Predicts Risk for Impotence After Prostate Cancer Therapy
3. Genes May Explain Blacks Bleaker Prostate Cancer Stats
4. The War on Cancer Continues
5. John Theurer Cancer Center among first clinical trial sites to join landmark MMRF study
6. MRI Can Spot Breast Cancer in High-Risk Women: Study
7. Higher Risk of Second Breast Cancer Seen in Black Women
8. 10 ways to make better decisions about cancer care
9. Costly blood clots more common than expected among cancer patients
10. Stem cells, potential source of cancer-fighting T cells
11. UNC scientist proves potential of new nanoparticle design for cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lung cancer research team awarded $1.43 million to study cancer in Eastern Kentucky
(Date:2/22/2017)... ... 2017 , ... Sideline Products participated in the World Horse Expo held in ... and his production crew. Tom Seay’s program “Best of America by Horseback” is ... Sidekicks will be featured on April 6, 2017. After the broadcast, the clip will ...
(Date:2/22/2017)... ... February 22, 2017 , ... The first-ever National ... organizations, advocates, and individuals join together to increase recognition about the risks of ... lives. , “Today we mark a nationwide movement to raise awareness about a ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... issues related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as ... one of a small number of neurosurgeons in Michigan performing minimally invasive back ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... company, launched a new media platform connecting healthcare technology professionals and other key ... followed by a quarterly publication starting on March 1, announced Michael J. Hennessy, ...
(Date:2/22/2017)... ... February 22, 2017 , ... Super-Sod will attend the Athens Home Show ... Georgia. , A shift from Super-Sod’s simple Athens Home Show booth of 2016, this ... grass seed plant manager Chris Roquemore constructed furniture from recycled pallet wood at the ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and MTA: ... fourth quarter and full year 2016 financial results on Thursday, ... financial markets. Following the announcement, members of the management ... the results and provide a general corporate update at 4:30 ... be obtained as follows: Thursday, March 2 ...
(Date:2/22/2017)... N.J. , Feb. 22, 2017  Andre, DiMino, ... technology-based developer and manufacturer of innovative technologies and products, ... results reported on February 21, 2017 in the Company,s ... . ADMT CEO Andre, DiMino stated "During ... our business plan by devoting a larger portion of ...
(Date:2/22/2017)... -- Ultra Clean Holdings, Inc. (Nasdaq: UCTT), a leading ... for the semiconductor capital equipment, flat panel, medical, ... results for the fourth quarter and fiscal year ... a year of extraordinary growth for UCT. Total ... together with continued focus on operational excellence resulted ...
Breaking Medicine Technology: