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Lung cancer culprit could offer target for therapy, UT Southwestern researchers report
Date:9/13/2010

or author, said the experiments also show that deleting miR-21 sensitizes the animals' cancer cells to a certain kind of chemotherapy, suggesting that inhibiting miR-21 in lung-cancer patients could be of therapeutic value.

"Methods currently exist to pharmacologically manipulate molecules like miR-21," said Dr. Olson, who directs the Nancy B. and Jake L. Hamon Center for Basic Research in Cancer and the Nearburg Family Center for Basic and Clinical Research in Pediatric Oncology. "More research will be needed before we know whether this is applicable to humans, but it's possible that a drug designed to inhibit miR-21 could help keep cancer at bay."

MiR-21 is a type of molecule called a microRNA. These small snippets of RNA the chemical cousin of DNA normally help coordinate and regulate the production of specific proteins in cells. When miRNAs go awry, however, diseases such as cancer can result.


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Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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