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Lung and bladder cancers have common cell-cycle biomarkers
Date:1/29/2014

and bladder with tobacco use they have a common etiology. And so Theodorescu and postdoctoral fellow Garret Dancik, PhD, gathered hundreds of samples of these cancers to explore them for common causes (or at least common predictive markers). The question was this: with so many tumor samples matched with corresponding patient outcomes, could the researchers pinpoint what it was in these tumors that led to favorable or less good patient results?

First, the researchers correlated gene expression to progression and survival in these samples, ending with a master list of all genes predictive of patient outcomes. Then they crossed these lists to look for commonalities between the cancers. Rather than single genes that predict outcomes in these cancer types, researchers found clusters or "modules" of adjusted genes, all under the umbrella of the network that controls the cell cycle.

"This is important not just because we identified a signature that may be prognostic in bladder and lung cancers, but because the idea of considering a 'module' of genes related to a specific process in this case, the cell cycle may be useful in other cancers, " Theodorescu says.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert  

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