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Lung and bladder cancers have common cell-cycle biomarkers
Date:1/29/2014

A University of Colorado Cancer Center study published in the journal PLoS ONE shows that bladder and lung cancers are marked by shared differences in the genetics that control the cell cycle. Measuring these genetic signatures could allow doctors to refine a patient's prognosis, choose appropriate treatments, and perhaps offer new treatments that target these shared genetic abnormalities.

"It's exciting: the CU Cancer Center has internationally recognized expertise in these two cancers lung and bladder and with this study we were able to find what is effectively a common denominator between these two major tobacco-related cancers. We know that many cancers rush through the cell cycle to replicate themselves faster than does healthy tissue, and now we see that some of the same processes are at work in both bladder and lung cancers," says Dan Theodorescu, MD, PhD, director of the CU Cancer Center and lead author of the study.

Biomarkers are the differences between cancerous and healthy cells that allow researchers and doctors to diagnose, predict the course of, and increasingly treat cancers. But with about 40,000 genes in the human genome and far more steps between a gene and its expression as a protein, finding meaningful biomarkers is the proverbial search for a needle in a haystack. Traditionally, tissue samples from one cancer type are collected and then the genes in these samples are analyzed to see which, if any, are elevated, silenced or mutated. Unfortunately, despite the success of this approach in identifying candidate biomarkers, many biomarkers fail to stand up to further scrutiny a gene that is elevated in a subset of 10 samples of, say, prostate cancer, may not be elevated in further cohorts of the same cancer.

The current study reasoned that biomarkers present in not just one but two or more related but different cancers would likely be more robust than single-cancer biomarkers. Previous studies link lung
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Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert  

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