Navigation Links
Lung Trouble Associated With Sickle Cell in Kids
Date:5/22/2008

Decline in function needs to be addressed more aggressively, study says

THURSDAY, May 22 (HealthDay News) -- Children with sickle cell disease lose lung function faster and more significantly as they age, compared with other children of the same race and age, according to new research.

Contrary to previous research, the difficulty in breathing appears linked to a restrictive rather than obstructive or asthma-like pattern.

"The restrictive pattern of decline is supportive of early injury or inflammation resulting in progressive changes in lung volumes across age," lead researcher Dr. Joanna MacLean, of the department of respiratory medicine at Children's Hospital at Westmead in Australia, said in a prepared statement. "We expected that children with sickle cell disease would show greater loss of lung function than other children, but this had never been quantified, nor was the pattern of decline clear."

The research was presented May 18 at the American Thoracic Society's 2008 International Conference, in Toronto.

To determine the patterns of loss of lung function, the researchers analyzed 1,357 lung function results that were completed between January 1989 and January 2005 from 413 children with sickle cell disease (SCD) during routine sickle cell clinical visits. Lung volume measurements were also included for 1,129 records.

Analyzing lung function test results on the 413 children taken over 16 years, the researchers noticed a decline in the percent predicted values for all spirometry measures except FEV1/FVC ratio, a marker of airway obstruction. This pattern of decline confirmed a restrictive pattern with an average loss of 2 percent per year of total lung capacity.

"Our findings confirm that lung disease in SCD begins in childhood," MacLean said. "Using statistical modeling, we are able to predict the rate of decline of lung function. These results can be used as a baseline against which results from intervention studies can be compared."

She said the results emphasize the need for further investigation into the causes and treatment of lung disease in children with sickle cell disease.

More information

The Sickle Cell Disease Association of America Inc. has more about sickle cell disease.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, May 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Erectile Dysfunction a Strong Harbinger of Heart Trouble
2. Childhood Cancer Survivors Prone to Early Heart Trouble
3. Low Levels of Vitamin D Spell Trouble for Breast Cancer Patients
4. Separation from mom, dad linked with learning trouble in kids
5. Survey Reveals Most Americans Planning Vacations Within the U.S.; Tummy Troubles Top Travel Health Woes
6. Kidney Trouble Short-Lived in Most Liver Transplant Patients
7. Double Trouble: Fight Allergy and Asthma in Your Home
8. Sleep Troubles Vary Between Alzheimers Patients, Caregivers
9. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
10. Postmenopausal Womens Sexual Dissatisfaction Not Linked to Heart Troubles
11. Amateur Singers, Teachers Seldom Hear Sounds of Trouble
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... ... a fine examination of how God handles sin, including how to let go of ... who, for over ten long years has been waiting to release this powerful insight about ... has been serving the Lord for over twenty years, and he has been preaching and ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a ... “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired ... collections. , “I have been writing since high school and have many different ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... an On-demand E-learning system for Clinical and Regulatory education for Physicians, Physician ... on Aerolib`s successful education methodology of Disease Specific Documentation Improvement. , The ...
(Date:1/19/2017)... Beach, Florida (PRWEB) , ... January 19, 2017 , ... ... J.D., LCSW, announced that the name of their drug rehab center in Delray Beach, ... time we recognize that not only stars such as Philip Seymour Hoffman and Chris ...
(Date:1/19/2017)... ... ... Cosmetic Town, an online plastic surgery community, begins 2017 with an update ... their readers to get the information they desire. The procedures are now listed according ... on those particular areas. , “We are excited to streamline our listings in a ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 19, 2017 Report Details ... Alzheimer,s Disease ... Companies – our new study reveals trends, R&D progress, ... events affecting the Alzheimer,s disease therapeutics and diagnostics market. ... key questions: - How is the Alzheimer,s disease therapeutics ...
(Date:1/19/2017)... , Jan. 19, 2017 Many patients don,t ... their medication when a pharmacy just a few blocks ...  To alleviate this problem Medicationdiscountcard.com has created ... see exactly how much their medication will cost at ... Easy Medicationdiscountcard.com takes ...
(Date:1/19/2017)... , January 19, 2017 Incretin Mimetics/GLP-1 ... and Others The global anti-obesity drugs market ... first half of the forecast period and CAGR of 38.7% in ... to grow at a CAGR of 32.8% from 2016 to 2027. ... in 2021, and $24,063 million in 2027. ...
Breaking Medicine Technology: