Navigation Links
Lung Trouble Associated With Sickle Cell in Kids
Date:5/22/2008

Decline in function needs to be addressed more aggressively, study says

THURSDAY, May 22 (HealthDay News) -- Children with sickle cell disease lose lung function faster and more significantly as they age, compared with other children of the same race and age, according to new research.

Contrary to previous research, the difficulty in breathing appears linked to a restrictive rather than obstructive or asthma-like pattern.

"The restrictive pattern of decline is supportive of early injury or inflammation resulting in progressive changes in lung volumes across age," lead researcher Dr. Joanna MacLean, of the department of respiratory medicine at Children's Hospital at Westmead in Australia, said in a prepared statement. "We expected that children with sickle cell disease would show greater loss of lung function than other children, but this had never been quantified, nor was the pattern of decline clear."

The research was presented May 18 at the American Thoracic Society's 2008 International Conference, in Toronto.

To determine the patterns of loss of lung function, the researchers analyzed 1,357 lung function results that were completed between January 1989 and January 2005 from 413 children with sickle cell disease (SCD) during routine sickle cell clinical visits. Lung volume measurements were also included for 1,129 records.

Analyzing lung function test results on the 413 children taken over 16 years, the researchers noticed a decline in the percent predicted values for all spirometry measures except FEV1/FVC ratio, a marker of airway obstruction. This pattern of decline confirmed a restrictive pattern with an average loss of 2 percent per year of total lung capacity.

"Our findings confirm that lung disease in SCD begins in childhood," MacLean said. "Using statistical modeling, we are able to predict the rate of decline of lung function. These results can be used as a baseline against which results from intervention studies can be compared."

She said the results emphasize the need for further investigation into the causes and treatment of lung disease in children with sickle cell disease.

More information

The Sickle Cell Disease Association of America Inc. has more about sickle cell disease.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, May 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Erectile Dysfunction a Strong Harbinger of Heart Trouble
2. Childhood Cancer Survivors Prone to Early Heart Trouble
3. Low Levels of Vitamin D Spell Trouble for Breast Cancer Patients
4. Separation from mom, dad linked with learning trouble in kids
5. Survey Reveals Most Americans Planning Vacations Within the U.S.; Tummy Troubles Top Travel Health Woes
6. Kidney Trouble Short-Lived in Most Liver Transplant Patients
7. Double Trouble: Fight Allergy and Asthma in Your Home
8. Sleep Troubles Vary Between Alzheimers Patients, Caregivers
9. Cutting Phosphate May Protect Kidney Patients From Heart Trouble
10. Postmenopausal Womens Sexual Dissatisfaction Not Linked to Heart Troubles
11. Amateur Singers, Teachers Seldom Hear Sounds of Trouble
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... DC (PRWEB) , ... February 11, 2016 , ... ... an upcoming Feb. 23 webinar, “Intel’s Direct-to-Employee Benefit Model: A Case Study for ... not-for-profit Catholic health care system that’s partnering with Intel on value-based health benefits ...
(Date:2/11/2016)... ... February 11, 2016 , ... veEDIS Clinical Systems, ... with highly adaptable algorithms, has been updated to help Emergency Department physicians and ... consistent with Zikas and a travel history to affected regions, or potential exposure ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... call for nominations seeking candidates for the Board of Commissioners. Individuals interested in ... skills and experience with diversity of clinical practice settings and across allied health ...
(Date:2/11/2016)... ... February 11, 2016 , ... "What holds you back from ... poses a question as a challenge for his readers to examine the full ... Being" (published by Partridge Singapore), Clarke explores the subject with more depth, revealing ...
(Date:2/11/2016)... ... 11, 2016 , ... PharmMD CEO Robert Yeager ... focus on contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will ... in data breaches for the Part D Star Rating improvement and Medication Therapy ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Biotechnology Inc., spurred by a major "team investment" by Bruce Montgomery , one of this ... A-Round, according to CEO Leen Kawas , PhD. ... ... ... Kawas said the round was intended ...
(Date:2/11/2016)... CARLSBAD, Calif. , Feb.11, 2016  Ionis Pharmaceuticals, Inc. ... a live webcast on Thursday, February 25 at 11:30 a.m. ... on pipeline and business progress. www.ionispharma.com . ... at the same address. --> www.ionispharma.com . A ... the same address. --> Interested parties may listen ...
(Date:2/11/2016)... -- Indiso ltd , a medical technology company ... respiratory diseases announced today positive results in its clinical ... patients show improvements in respiratory functions and other clinical ... Upper and lower respiratory tract diseases and allergy ... reached epidemic level. Increasing number of studies however show ...
Breaking Medicine Technology: