Navigation Links
Lung Enzyme Both Friend and Foe
Date:6/17/2009

MMP-12 contributes to emphysema, but also guards against infection, study shows

WEDNESDAY, June 17 (HealthDay News) -- An enzyme involved in the development of emphysema also defends the lungs against bacterial infection, a new study finds.

It had been thought that the only thing macrophage elastase, matrix metalloproteinase-12 (MMP-12), did was degrade lung elasticity as part of the tissue destruction seen in emphysema patients.

"But we found that mice that didn't have the gene to make this enzyme could not clear bacteria well and were more likely to die of infection. They couldn't make this small protein, which kills bacteria by poking holes in cell membranes," study author Dr. A. McGarry Houghton, an assistant professor in the Division of Pulmonary, Allergy and Critical Care Medicine at the University of Pittsburgh School of Medicine, said in a university news release.

The researchers also found that MMP-12's antimicrobial activity comes from a small part of the enzyme that's structurally and sequentially unique.

"Humans, mice, rats and rabbits all have that special sequence and structure in MMP-12, but not in other MMPs," Houghton said.

The study appears in the June 17 issue of Nature.

"While not the initial purpose of this study, finding novel antimicrobial mechanisms is extremely important," senior study author Dr. Steven D. Shapiro, chair of the Department of Medicine at the University of Pittsburgh School of Medicine, said in the same release. "Many microorganisms have adapted to circumvent our current and stagnant arsenal of antibiotics. We must find new weapons so that we don't fall back to the public health problems we had prior to penicillin."

The researchers plan to investigate whether the special sequence and structure in MMP-12 can kill viruses and fungi.

More information

The American Lung Association has more about emphysema.



-- Robert Preidt



SOURCE: University of Pittsburgh Schools of the Health Sciences, news release, June 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. High Activity, Plant Based Diamine Oxidase Enzyme Introduced by Bio-Research Products
2. Video: CREON(R) (Pancrelipase) Delayed-Release Capsules First and Only Pancreatic Enzyme Product to Receive FDA Approval Under New Guidelines
3. Reversing effects of altered enzyme may fight brain tumor growth
4. Former Executive at Genzyme Corp. and Osiris Therapeutics, Inc. to Head Business Advisory Board at Rx for Africa, Inc.
5. Enzyme and vitamin define the yin and yang of asthma
6. FDA Warning Letter to Genzyme Related to the Allston Manufacturing Facility
7. Enzyme weakens the heart
8. Durability of dental fillings improves if the enzyme activity of teeth is inhibited
9. Unique Glutathione Reductase Enzyme Introduced by Bio-Research Products
10. Enzyme with a sugar antenna
11. Low Levels of 2 Enzymes in Ovarian Cancer Cells Shortened Survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lung Enzyme Both Friend and Foe
(Date:5/26/2016)... ... May 26, 2016 , ... North Cypress Medical Center hosted ... Club in Cypress. With the help of community partners, the event organizers raised $45,000 ... hope for wounded service members and their families through health, wellness, and therapeutic support. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a leading developer ... Instructor Certification Course in Stoughton, Massachusetts. The course was led by Power Systems’ ... 8 hour interactive course to qualify participants as certified PowerWave trainers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our ... PROTECTION TO YOUR HEAD ™”. , “We are proud to introduce Meghan ... football front we have Brian Quick, wide receiver for Los Angeles who was a ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. LeRoy Perry’s recently ... impact of mobile devices on the billions of users, hundreds of millions of whom ... While not life threatening, the frequent and common action of looking down at hand-held ...
(Date:5/26/2016)... ... May 26, 2016 , ... In Madeira Beach Florida, a small ... single drawbridge, citizens formed an organization, Madeira Beach United, to oppose two development projects ... small town center to a high rise urban environment. , According to the ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 The ... world , s first dual therapy stent, ...   OrbusNeich, a global company specializing in ... portfolio to include products to treat peripheral artery disease. ... first entry devices for lower limb and arteriovenous (AV) ...
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... met elkaar verbindt, zodat zij collectief patiënten kunnen behandelen, ... Dat is het idee achter de nieuwe en revolutionaire ... aanvoering van de Nederlandse vaatchirurg dr. Hans Flu en ... MDLinking app, die inmiddels beschikbaar is, wordt op dinsdag ...
(Date:5/23/2016)... NEW YORK , May 23, 2016 /PRNewswire/ ... Mass Spectrometry Market Size, Share, Development, Growth and ... Platform (Hybrid, Single and Other), by Application (Drug ... Others), by End Users (Pharmaceuticals, Life Science and ... Published by P&S Market Research, the global ...
Breaking Medicine Technology: