Navigation Links
Lung Cancer Microscopic Appearance Affects Response to Chemotherapy

Tumor Structure Should Be Considered in Treating NSCLC, Says Report in "The Oncologist"

DURHAM, N.C., Feb. 17 /PRNewswire/ -- A tumor's cellular structure, or histology, improves treatment decisions that may lead to improved outcomes for patients with non-small cell lung cancer (NSCLC), the most common type of lung cancer, according to a paper in the latest issue of "The Oncologist."

(Logo: )

The findings are based on an analysis of recent studies of the chemotherapy drug pemetrexed to treat NSCLC. "The data confirm that histology matters when treating NSCLC," says Professor Giorgio Scagliotti, M.D., of University of Turin, lead author of the new report.

Prof. Scagliotti and colleagues analyzed data from two recent phase III studies of pemetrexed for NSCLC, which accounts for about 90 percent of all lung cancers. They focused on how differences in cancer histology affect the response to treatment with pemetrexed. The histology of a cancer is its microscopic cellular structure and in NSCLC, tumors may be classified as having a "squamous" or "non-squamous" appearance.

Their analysis showed significant differences in response to pemetrexed between these two lung cancer subtypes. Specifically, pemetrexed was more effective than current forms of chemotherapy against cancers with a non-squamous histology. For these patients, pemetrexed led to significant improvements in overall survival and in survival without progressive cancer. In contrast, for patients whose cancers had the squamous histology, outcomes were similar with or without pemetrexed.

The two studies were a "frontline" trial including patients with previously untreated NSCLC and a "second-line" trial including patients with previous chemotherapy. The interaction between cancer histology and response to pemetrexed was similar in both groups of patients. Based on the results of the frontline trial, pemetrexed has been approved for initial treatment of NSCLC in Europe, Canada and the United States, in combination with cisplatin, another chemotherapy drug.

In the past, cancer histology hasn't been considered in selecting treatments for patients with NSCLC. "For more than 25 years medical oncologists have simply looked at the distinction between small-cell and non-small-cell lung cancer in making systemic treatment decisions," says Prof. Scagliotti. "This is because there has previously been no convincing evidence that the available treatments have any differential activity based on the histologic subtype of NSCLC." "On the basis of these studies, tumor histology should be carefully assessed when selecting treatment options for patients with advanced NSCLC," says Prof. Scagliotti.

The article entitled "The Differential Efficacy of Pemetrexed According to NSCLC Histology: A Review of Two Phase III Studies," has been published by "The Oncologist," and is freely available online at:

About AlphaMed Press

AlphaMed Press publishes the internationally renowned journals, "Stem Cells" and "The Oncologist." "Stem Cells," now in its 27th year, is the oldest and one of the world's top-tier peer-reviewed monthly journals in the fast-paced area of stem cells and regenerative medicine. "The Oncologist," in its 14th year, is a premier peer-reviewed monthly journal dedicated to physicians entrusted with the care of cancer patients. View AlphaMed Press journals at

Contact: Dr. Martin J. Murphy, Executive Editor: 919.402.8750,

SOURCE AlphaMed Press
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Targeting the protein AEG1 impairs human liver cancer growth in mice
2. Hodgkins Survivors Prone to Breast Cancer Later
3. Social Disconnection in African American Women With Breast Cancer
4. Researchers ID Biomarker for Fatal Prostate Cancer
5. Teens with cancer present unique psychological issues
6. SpectraScience Secures Distribution for WavSTAT(R) Cancer Diagnosis System in Greece & Cyprus
7. New Anti-Clotting Treatment Urged for Cancer Patients
8. Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers
9. Normalizing tumor vessels leaves cancer more benign
10. Womens cancer outcomes improved by surgical evaluation
11. Pediatric Hodgkins disease survivors face increased breast cancer risk
Post Your Comments:
(Date:11/27/2015)... ... 28, 2015 , ... There is only one major question facing all law ... , This question has not been an easy question to answer. Especially when the ... the younger workforce don’t share the same discipline around working long hours. , ...
(Date:11/27/2015)... ... 27, 2015 , ... A team of Swiss doctors has released a report ... has just posted the findings on the website. Click here to read the ... 136 mesothelioma patients who were treated with chemotherapy followed by EPP surgery. Among the ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... ... use in Final Cut Pro X. With ProSidebar: Fasion, video editors can easily ... use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating drop zones, ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... Consultants has prided itself for not only fulfilling the needs of advisers and ... at an affordable price and providing top-tier customer service. However, there's always room ...
(Date:11/27/2015)... Francisco, California (PRWEB) , ... November 27, 2015 , ... ... Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of Joplin's ... at the Canterbury House at the University of Michigan in Ann Arbor. The According ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... and NUREMBERG, Germany , Nov. 29, ... leader Ziehm Imaging invites attendees to experience the most ... market. The highlight on display is Ziehm Vision RFD ... that provides a 16 cm edge length per scan ... Hybrid Edition, the first fully motorized mobile C-arm in ...
(Date:11/27/2015)... --> --> ... The potential to save costs, improve treatment quality and ... fully exploited as yet. Here, particular emphasis is placed ... mobile tablet or directly at the patients, bedside. ... ) -->      (Photo: ...
(Date:11/26/2015)... India , November 27, ... --> --> ... personal emergency response system (PERS) ... steadily for 5 years with ... region expected to see a ...
Breaking Medicine Technology: