Navigation Links
Lung Cancer Evolves With Treatment, Study Finds
Date:3/23/2011

WEDNESDAY, March 23 (HealthDay News) -- A new study helps explain how some lung cancers become resistant to targeted drug therapy.

Researchers at the Massachusetts General Hospital Cancer Center analyzed tumor samples from 37 patients with non-small cell lung cancer, the leading cause of cancer death worldwide, and identified two new genetic changes associated with resistance.

They also confirmed resistance-related genetic changes identified in previous studies.

The MGH team also discovered that the cellular nature of some tumors changes in response to treatment and that genetic mutations associated with drug resistance can disappear after treatment is halted.

The findings highlight the importance of monitoring the molecular status of lung cancer tumors throughout the treatment process, the researchers said.

"It is really remarkable how much we oncologists assume about a tumor based on a single biopsy taken at one time, usually the time of diagnosis," lead author Dr. Lecia Sequist said in an MGH news release. "Many cancers can evolve in response to exposure to different therapies over time, and we may be blind to the implications of these changes simply because we haven't been looking for them."

"Our findings suggest that, when feasible, oncogene-driven cancers should be interrogated with repeat biopsies throughout the course of the disease," Sequist said. "Doing so could both contribute to greater understanding of acquired resistance and give caregivers better information about whether resumption of targeted therapy or initiation of a standard therapy would be most appropriate for an individual patient."

The study appears March 23 in the journal Science Translational Medicine.

More information

The American Cancer Society has more about

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Statins make radiation more effective at curing prostate cancer
2. UT MD Anderson receives grant for study of acupuncture in cancer
3. Discovery in liver cancer cells provides new target for drugs
4. Tamoxifen May Offer Long-Term Heart, Cancer Protection
5. Jefferson clinical trial: Can a cholesterol drug prevent colon cancer?
6. Good news for meat lovers: Most ready-to-eat meat products contain very few cancerous compounds
7. Philanthropic pledge triples funds for TGen ovarian cancer research
8. Smoke-Free Environments Linked to Less Breast Cancer
9. The MMRF and John Theurer Cancer Center to host patient symposium
10. Does selenium prevent cancer? It may depend on which form people take
11. Malaria drug slows pancreatic cancer growth in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lung Cancer  Evolves With Treatment, Study Finds
(Date:5/24/2015)... May 24, 2015 The Rolling Stones ... 24th in San Diego at Petco Park. This iconic ... On May 20th, they had a warmup show in ... preview show in Los Angeles, this beloved band not only ... played fan favorites such as "Jumping Jack Flash," "Moonlight ...
(Date:5/24/2015)... Scientists with Cardno ChemRisk, a scientific consulting ... issues that may have raised the risk of mesothelioma ... posted an article on the research. Click here ... airborne asbestos levels well above OSHA safety guidelines when ... , “Asbestos compliance sampling data associated with the construction, ...
(Date:5/24/2015)... 2015 Indiana Fiber Network, LLC (IFN), ... Telecom of America, Inc. (MTA) has selected IFN as ... Childs, IFN Enterprise Sales Manager, fiber route diversity and ... fiber transport provides MTA with the diverse fiber transport ... 1 Internet and voice carriers located at Henry Street ...
(Date:5/23/2015)... 2015 On Saturday, May 23, 2015, over ... for Branches Florida City exactly five years to the day ... 2010. , A large fire tore through the Branches United ... 2010 in the middle of the night as neighbors, staff ... declared arson even though it is suspected that the fire ...
(Date:5/23/2015)... York, NY (PRWEB) May 23, 2015 ... announced that, “the company has been the target ... as a part of the company’s ongoing Information Technology ... on health insurers.” , The most notable attack ... year when Anthem Inc., the nation’s second largest health ...
Breaking Medicine News(10 mins):Health News:The Rolling Stones Tickets in San Diego, Orlando, Minneapolis, Dallas, Pittsburgh, Indianapolis, Atlanta, Detroit, Milwaukee, Kansas City, Columbus, Nashville & Raleigh 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4
... more districts in Cambodia's eastern province Kampong Cham. According to ... ,"We have discovered two more outbreaks of bird ... Phal, the director of animal health at the agriculture ministry, ... on dead duck samples taken from the two districts has ...
... the Mahim beach to drink sweet seawater for the ... drinking// the polluted water. ,Scientists clarified that ... phenomenon of dilution. ,"Dilution is a phenomenon ... the southwest monsoon and occurs when rainwater borne by ...
... Indo-American cardiologist was fired by the Cleveland Clinic for ... with a device developed by him.// Yadav is the ... used in carotid stenting procedures. Yadav was affiliated to ... of the Clinic's Innovations Foundation. ,A statement ...
... light and strong tennis rackets…. The way things ... this technology will// have its greatest influence on ... at Rush University Medical Center in Chicago think ... ovarian cancer can be developed using nanotechnology. Rush ...
... that could hold clues as to the evolution of the ... that the gene discovered has undergone a quickened evolutionary change ... brain development. The researchers have stated that though they are ... evidence they have come across seemingly suggests that it might ...
... Robert H. Lustig, pediatric endocrinologist and nationally renowned obesity ... that the obesity epidemic// is caused by a "poisoned" ... them to eat more and move less. He proposed ... Nature Clinical Practice: Endocrinology and Metabolism, after gathering results ...
Cached Medicine News:Health News:Maharashtra warns against Mahim's 'miracle' water 2Health News:Indo-American Doctor Fired By Cleveland Clinic 2Health News:Indo-American Doctor Fired By Cleveland Clinic 3Health News:Indo-American Doctor Fired By Cleveland Clinic 4Health News:Nanotechnology – to detect and treat ovarian cance 2Health News:Nanotechnology – to detect and treat ovarian cance 3Health News:A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity 2Health News:A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity 3Health News:A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity 4Health News:Processed foods – "the" cause of obesity! 2Health News:Processed foods – "the" cause of obesity! 3Health News:Processed foods – "the" cause of obesity! 4
(Date:5/22/2015)... Today, Rhodes Pharmaceuticals L.P. announced that Aptensio ... for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) will ... The announcement comes just one month ... Food and Drug Administration (FDA). ... capsule with an onset of effect of 1 ...
(Date:5/22/2015)... REDWOOD CITY, Calif. , May 22, 2015 /PRNewswire/ ... specialty pharmaceutical company focused on the development and commercialization ... breakthrough pain, today announced that interim chief executive officer ... 2015 Healthcare Conference and chief financial officer Tim ... Science Conference. Details of the two presentations are as ...
(Date:5/21/2015)... CHICAGO , May 21, 2015 /PRNewswire-USNewswire/ ... lump along the side of his neck, ... and took a couple weeks off from ... didn,t go away.                               ... Rendino, 26, was referred to Michel ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4
... Cadence Pharmaceuticals, Inc. (NASDAQ: CADX ), a ... products principally for use in the hospital setting, today ... September 30, 2011 financial results on Thursday, November 3, ... conference call and live webcast to discuss the financial ...
... FRAMINGHAM, Mass. and SYDNEY, Oct. 27, 2011 HeartWare ... a leading innovator of less invasive, miniaturized circulatory support ... failure, announced today that David McIntyre, Chief Financial Officer ... family back to Australia for personal reasons and will ...
Cached Medicine Technology:HeartWare International Announces Planned Departure of Chief Financial Officer 2HeartWare International Announces Planned Departure of Chief Financial Officer 3HeartWare International Announces Planned Departure of Chief Financial Officer 4
REFRESH TEARS® lubricating eye drops does more than just smoothe and relieve dry, irritated eyes. REFRESH TEARS® creates a shield of protection against further irritation with its unique, lon...
... REFRESH ENDURA™ is the first ... benefit all 3 layers of ... of moisture that lubricates and ... eyes). This helps seal in ...
ALPHAGAN® (brimonidine tartrate ophthalmic solution) 0.2% is indicated for lowering IOP in patients with open-angle galucoma or ocular hypertension....
... solution is a prescription eye drop ... to use after your cataract surgery. ... may cause them to become inflamed. ... inflammation include redness and swelling. If ...
Medicine Products: