Navigation Links
Lung Cancer Evolves With Treatment, Study Finds
Date:3/23/2011

WEDNESDAY, March 23 (HealthDay News) -- A new study helps explain how some lung cancers become resistant to targeted drug therapy.

Researchers at the Massachusetts General Hospital Cancer Center analyzed tumor samples from 37 patients with non-small cell lung cancer, the leading cause of cancer death worldwide, and identified two new genetic changes associated with resistance.

They also confirmed resistance-related genetic changes identified in previous studies.

The MGH team also discovered that the cellular nature of some tumors changes in response to treatment and that genetic mutations associated with drug resistance can disappear after treatment is halted.

The findings highlight the importance of monitoring the molecular status of lung cancer tumors throughout the treatment process, the researchers said.

"It is really remarkable how much we oncologists assume about a tumor based on a single biopsy taken at one time, usually the time of diagnosis," lead author Dr. Lecia Sequist said in an MGH news release. "Many cancers can evolve in response to exposure to different therapies over time, and we may be blind to the implications of these changes simply because we haven't been looking for them."

"Our findings suggest that, when feasible, oncogene-driven cancers should be interrogated with repeat biopsies throughout the course of the disease," Sequist said. "Doing so could both contribute to greater understanding of acquired resistance and give caregivers better information about whether resumption of targeted therapy or initiation of a standard therapy would be most appropriate for an individual patient."

The study appears March 23 in the journal Science Translational Medicine.

More information

The American Cancer Society has more about non-small-cell lung cancer.

-- Robert Preidt

SOURCE: Massachusetts General Hospital, news release, March 23, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Statins make radiation more effective at curing prostate cancer
2. UT MD Anderson receives grant for study of acupuncture in cancer
3. Discovery in liver cancer cells provides new target for drugs
4. Tamoxifen May Offer Long-Term Heart, Cancer Protection
5. Jefferson clinical trial: Can a cholesterol drug prevent colon cancer?
6. Good news for meat lovers: Most ready-to-eat meat products contain very few cancerous compounds
7. Philanthropic pledge triples funds for TGen ovarian cancer research
8. Smoke-Free Environments Linked to Less Breast Cancer
9. The MMRF and John Theurer Cancer Center to host patient symposium
10. Does selenium prevent cancer? It may depend on which form people take
11. Malaria drug slows pancreatic cancer growth in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Lung Cancer  Evolves With Treatment, Study Finds
(Date:5/4/2016)... , ... May 04, 2016 , ... Nike Rugby Camp's ... rugby in San Diego. Willis, founder of Elite Rugby Camps and current Nike Camp ... players every year since 2009. , “I’m excited for our eighth summer here ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... Continence Nurses (WOCN) Society™ and Canadian Association for Enterostomal Therapy (CAET) will ... time saving and planning tools to attendees and exhibitors for the 2016 WOCN ...
(Date:5/4/2016)... , ... May 04, 2016 , ... A new collaboration ... world. The Duke Clinical Research Institute (DCRI) and analytics leader SAS will provide researchers ... data collected by the Duke University Health System. , The DCRI and SAS ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... Hight-Doland Insurance ... area has teamed up with Big Brothers Big Sisters of Southwest Louisiana to help ... accepted here . , Big Brothers Big Sisters of Southwest Louisiana has been ...
(Date:5/4/2016)... ... 2016 , ... All-Star Insurance of Northeast TX has announced ... their local community. The agency pledges to select a new beneficiary every 60 ... bring awareness to important local causes with fundraising and other support, by forming ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 2016 According to market research "Global ... Forecast to 2022 - Industry Insights by Slice Type (High, ... Others)" by P&S Market Research, the global computed tomography ... it is expected to grow at a CAGR of 5.0% ... segment is expected to witness the faster growth, CAGR of ...
(Date:5/4/2016)... 2016 Yissum Research Development ... today that it had signed an exclusive world-wide licensing ... of novel protein degradation and immunomodulatory drugs for cancer ... drug candidates representing first-in-class therapy for hematologic and solid ... The novel technology was developed by ...
(Date:5/4/2016)... 4, 2016 In March, ... series of free workshops across Africa ... requirements for Good Distribution Practices (GDP). Good Distribution ... that products are consistently stored, transported and handled under ... or product specification. Only a few years ago, there ...
Breaking Medicine Technology: