Navigation Links
Lumbar disc degeneration more likely in overweight and obese adults
Date:1/30/2012

One of the largest studies to investigate lumbar spine disc degeneration found that adults who are overweight or obese were significantly more likely to have disc degeneration than those with a normal body mass index (BMI). Assessments using magnetic resonance imaging (MRI) show elevated BMI is associated with an increased number of levels of degenerated disks and greater severity of disc degeneration, including narrowing of the disc space. Details of this study now appear in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

The World Health Organization (WHO) reports that obesityone of the most preventable risk factors for a number of diseaseshas more than doubled since 1980. According to WHO, in 2008 roughly 1.5 billion people aged 20 and older were overweight, with more than 200 million men and close to 300 million women considered obese. In the U.S., studies estimate one in three children is overweight or obese and excess weight could lead to more severe obesity in adulthood.

Moreover, previous research has linked higher BMI to low back pain, which is often debilitating and can limit function, impact psychological well being, diminish overall quality of life, and is associated with substantial socioeconomic and health-care costs. Experts suggest that disc degeneration is one cause of low back pain, and therefore, BMI could be involved in the development of degenerative disc disease. To expand the knowledge of this important health concern, a team of researchers led by Drs. Dino Samartzis and Kenneth M.C. Cheung at the University of Hong Kong in Hong Kong investigated the association between elevated BMI and presence, extent, and severity of lumbar spine disc degeneration on MRI in adults.

The team recruited 2,599 participants aged 21 and older from Southern China between 2001 and 2009. Participants were from diverse social and economic backgrounds and were recruited regardless of whether they had lower back pain or not. The study group included 1,040 men and 1,559 women who had a mean age of 42 years. Researchers conducted radiographic and clinical assessments, and MRIs of the lumbar spine were obtained for all subjects.

Study findings reveal that 73% of participants displayed disc degeneration, with men (76%) having a significantly higher prevalence of degeneration than women (71%). Not surprisingly, increasing age was found to increase the prevalence of disc degeneration. BMI assessments of the study group show that 7% of subjects were underweight, 48% were in the normal weight range, 36% were overweight, and 9% were obese.

"Our research confirms that with elevated BMI there is a significant increase in the extent and global severity of disc degeneration. In fact, end-stage disc degeneration with narrowing of the disc space was more pronounced in obese individuals," said Dr. Samartzis. The authors suggest that with weight gain, physical loading on the disc and/or a chronic low-grade inflammation from the fat cells may play a role in disc degeneration. Dr. Samartzis further added that "Since overweight and obesity are worldwide concerns whose prevalence continues to rise, our study's findings have considerable public health implications. If these issues continue to plague society, they can further affect spine health leading to low back pain and its consequences."

The authors note that disc degeneration is a complex process involving structural and chemical changes of the disc. They recommend that future studies that investigate risk factors for disc degeneration should take into account the impact of overweight and obesity on the disease. Dr. Cheung concludes, "Deeper understanding of how elevated BMI contributes to disc degeneration and low back pain could aid in the development of novel interventions that can improve quality of life for those with these disabling conditions."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Surgical treatment within six months of lumbar disc herniation
2. Transforaminal steroid injection for lumbar radicular pain proves superior to placebo
3. Disruption of biological clocks causes neurodegeneration, early death
4. Regulatory enzyme overexpression may protect against neurodegeneration in Huntingtons disease
5. Researchers ID genetic mutation associated with high risk of age-related macular degeneration
6. Mayo Clinic detective work shows possible side effect in macular degeneration drug
7. Single traumatic brain injury may prompt long-term neurodegeneration
8. Columbia researchers work to prevent blindness from age-related macular degeneration
9. Mayo Clinic finds new genetic cause of neurodegeneration
10. U-M researchers discover way to block neurodegeneration in an adult form of Fragile X syndrome
11. Diabetes gene linked to degeneration of enzyme involved in Alzheimers disease onset and progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... The Aging in Motion ... established an ICD-10-CM code for sarcopenia, giving it recognition for separate reporting and data ... October 1, 2016. , Sarcopenia is defined as a combination of low muscle mass ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... affected by a health insurance co-operative bankruptcy to receive their prescription medications ... receive over 1,500 FDA-approved prescription medications from over 180 American pharmaceutical companies ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... announced its latest offering, the Protocol Calendar Exchange , is officially open ... pre-built, pre-reviewed protocol calendars available for sites to download into their clinical trial ...
(Date:4/28/2016)... Vail, Colorado (PRWEB) , ... April 28, 2016 ... ... LaPrade, MD, PhD, Chief Medical Officer at the Steadman Philippon Research Institute ... Capitol Hill Day to raise awareness about the debilitating and costly musculoskeletal ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... intelligent business communication applications and infrastructure for telecommunication service providers is pleased ... at Bestel’s Communications Network. The ACONYX Number Portability solution fully meets ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... MARLTON, N.J. , April 28, 2016   ... solutions, today announced that leading IT market research and ... Player " in the IDC MarketScape: Worldwide Pharmaceutical Track ... March 2016).  The report provides an assessment of the ... pharmaceutical track and trace software market. Logo ...
(Date:4/27/2016)... 2016  Hologic, Inc. (Nasdaq: HOLX ... the fiscal second quarter ended March 26, 2016.  ... increased 41.2%, and non-GAAP diluted EPS of $0.47 ... on a reported basis, and 6.3% on a ... another good quarter, highlighted by 14.6% growth in ...
(Date:4/27/2016)... -- Elekta today announced that its leading-edge ... focal point of seven scientific presentations at ESTRO 35, ... & Oncology, taking place April 29 - May 3. ... and a high-field MRI scanner with sophisticated software that ... in real time. The MR-linac is designed to improve ...
Breaking Medicine Technology: