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Ludwig Cancer Research and CRI collaborate on VentiRx's investigational immunotherapy
Date:9/3/2014

ble to deliver powerful new treatments to cancer patients today while helping the field unlock immunotherapy's full potential more quickly."

Motolimod specifically binds and activates toll-like receptor-8 (TLR-8). TLR8 is found inside dendritic cells, which are patrolling immune cells that instigate, direct and fuel the immune response against infectious agents and malignant cells. When activated by motolimod, TLR-8 prompts dendritic cells within tumors to secrete factors that fuel a cascade of immune responses. This draws the innate immune system's natural killer (NK) cells into the fray, promotes the antibody-mediated destruction of malignant cells and, ultimately, supports the activation of T cells that specifically target the cancer.

"We are very excited to collaborate with Ludwig and CRI and benefit from their significant expertise in enabling this important clinical trial," said Robert Hershberg, MD, PhD, President and CEO at VentiRx. "Previous studies have shown that when motolimod (VTX-2337) is given in combination with certain chemotherapies, it enhances immune responses within the tumor microenvironment. We are confident that, as a potent activator of the innate immune response, motolimod will prove even more effective as a component of combination immunotherapy."


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Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

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