Navigation Links
Ludwig Cancer Research and CRI collaborate on VentiRx's investigational immunotherapy
Date:9/3/2014

September 3, 2014, New York, NY and Seattle, WA The nonprofits Ludwig Cancer Research (Ludwig) and the Cancer Research Institute (CRI) announced today an agreement with VentiRx Pharmaceuticals Inc., a clinical stage biopharmaceutical company, to conduct a clinical trial with motolimod (VTX-2337) combined with other immunotherapy agents available to Ludwig and CRI through other industry partnerships. VentiRx will provide motolimod, the company's lead immuno-oncology agent, for the study, which will be conducted by Ludwig and CRI through their jointly coordinated CVC Trials Network.

"Ludwig's mission is to conduct basic, applied and clinical research to support the swift development of game-changing cancer therapies," said Jonathan Skipper, PhD, Ludwig's executive director of technology development. "Motolimod holds considerable promise as a cancer drug, particularly as a component of combination immunotherapies. We look forward to working with VentiRx to assess its potential in clinical trials, as part of our effort to bring powerful new immunotherapies as quickly as possible to cancer patients."

Immuno-oncology, as the name implies, recruits the immune system into the battle against cancer, either by boosting its existing but latent anti-tumor responses or honing its recognition of malignant cells. Several recent studies have shown that such therapies, especially when used in combination, can induce potent and durable control of advanced cancers, in some cases resulting in lasting remissions.

"Our collaboration with VentiRx is part of a broader programmatic effort to partner with top biotech and pharmaceutical companies to develop novel combinations of treatments that may work better together than each would alone," said Adam Kolom, managing director of CRI's venture fund. "By making it possible for leading academic oncologists to bring together the most promising and mechanistically distinct drugs from different companies, we are able to deliver powerful new treatments to cancer patients today while helping the field unlock immunotherapy's full potential more quickly."

Motolimod specifically binds and activates toll-like receptor-8 (TLR-8). TLR8 is found inside dendritic cells, which are patrolling immune cells that instigate, direct and fuel the immune response against infectious agents and malignant cells. When activated by motolimod, TLR-8 prompts dendritic cells within tumors to secrete factors that fuel a cascade of immune responses. This draws the innate immune system's natural killer (NK) cells into the fray, promotes the antibody-mediated destruction of malignant cells and, ultimately, supports the activation of T cells that specifically target the cancer.

"We are very excited to collaborate with Ludwig and CRI and benefit from their significant expertise in enabling this important clinical trial," said Robert Hershberg, MD, PhD, President and CEO at VentiRx. "Previous studies have shown that when motolimod (VTX-2337) is given in combination with certain chemotherapies, it enhances immune responses within the tumor microenvironment. We are confident that, as a potent activator of the innate immune response, motolimod will prove even more effective as a component of combination immunotherapy."


'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Related medicine news :

1. The Ludwig Institute for Cancer Research announces launch of iTeos Therapeutics SA
2. LSU Health New Orleans awarded grant to provide early data on cancer in kids
3. Global snapshot of infectious canine cancer shows how to control the disease
4. Breast cancer patients with bilateral mastectomy dont have better survival rates
5. ‘Prepped’ by tumor cells, lymphatic cells encourage breast cancer cells to spread
6. New Guidelines for Treating Form of Advanced Breast Cancer
7. Enzyme controlling metastasis of breast cancer identified
8. New method for non-invasive prostate cancer screening
9. DynaMed™ to Utilize Information from the National Comprehensive Cancer Network®
10. Family conflicts, other non-physical worries before cancer surgery raise patients complication risk
11. New York Law Firm Discusses Allegedly Dangerous Surgical Morcellator Devices And Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, ... the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where ... city’s history as home to some of the world’s leading providers of cereal and ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... awareness about the dangers associated with chronic pain and the benefits of holistic treatments, ... for individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
Breaking Medicine Technology: