Navigation Links
Loyola researchers identify risk factor for life-threatening disease in preemies
Date:1/16/2014

Many premature infants suffer a life-threatening bowel infection called necrotizing enterocolitis (NEC).

Researchers at Loyola University Health System have identified a marker to identify those infants who are at risk for the infection, enabling doctors to employ early preventive strategies. These findings were published in the latest issue of the Journal of Pediatric Surgery.

"This information will allow us to better care for these premature infants," said Jonathan Muraskas, MD, study investigator and co-medical director of Loyola's neonatal ICU. "Simple changes to blood transfusion practices, feeding patterns and treatment of these infants may significantly reduce the incidence of NEC."

NEC is the most common serious gastrointestinal disorder among preterm newborns. It affects up to 10 percent of extremely low birth weight infants and has a mortality rate of nearly 30 percent. There is no known cause for the disease, yet researchers believe it may result from a combination of decreased blood flow to the bowel, feeding patterns, infection, mechanical injury or abnormal immune response.

NEC occurs when the lining of the intestinal wall dies and tissue falls off. Most cases of NEC are mild to moderate and can be successfully treated with antibiotics. But in severe cases, a hole can develop in the intestine, allowing bacteria to leak into the abdomen causing a life-threatening infection.

This study evaluated 177 infants born at less than 32 weeks' gestation and/or babies who were less than 3 pounds, 3 ounces. Blood samples were collected from these infants within 72 hours of birth and weekly for four weeks to measure reticulated platelets (RP) and intestinal alkaline phosphatase (iAP). Of the 177 infants, 15 (8.5 percent) developed NEC. Of these, 93 percent had low RP levels and 60 percent had high iAP. Those infants with low RP levels were significantly more likely to develop NEC while those with high iAP showed a similar trend.

"Decreased reticulated platelets serve as a sensitive indicator for NEC onset," Dr. Muraskas said. "Further research also may find that infants with elevated iAP levels may be at risk for this serious illness."


'/>"/>
Contact: Nora Dudley
nodudley@lumc.edu
708-216-6268
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Loyola receives Innovation Award for clinical research database
2. Loyola University New Orleans’ School of Nursing is Ranked Among Best Online Nursing Programs for Third Straight Year
3. Loyola bioethics study finds medical students concerned about desensitization to dying patients
4. Loyola neurologist is co-editor of 3-volume, 1,480-page guide to clinical neurology
5. Osteoporosis drugs compared for side effects, efficacy in Loyola study
6. Risk of osteoporosis drugs side effects not significant, Loyola researchers find
7. Loyola study assesses use of fingerstick blood sample with i-STAT point-of-care device
8. Loyola University New Orleans Hosts Newly Appointed U.S. Commerce Secretary
9. Loyola School of Nursing Online DNP Program Receives Federal Grant for Health Training
10. Loyola nuclear medicine technologist named National Technologist of the Year
11. Loyola receives $1.5 million grant to study vitamin D for diabetes and depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... December 07, 2016 , ... When it came time to blow out his candles on ... later, the Pediatric Heart Transplant team at Joe DiMaggio Children’s Hospital surprised his ... the hospital’s 30th heart transplant recipient. , “He was playing at home, when we ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... financial consultation services to residents in the Sacramento/Folsom region, is initiating a charity ... facility. , The Another Choice Another Chance treatment center in Sacramento works to ...
(Date:12/7/2016)... , ... December 07, 2016 , ... AlignLife clinics nationwide ... Many children are not fortunate enough to receive bountiful gifts wrapped tightly under a ... can bring to the children of the world. , In exchange for generous donations, ...
(Date:12/7/2016)... OR (PRWEB) , ... December 07, 2016 , ... Sharon ... Water, Global Climate Change and Your Health on Voice of America, declared on her ... to call attention to the fact that when these bullies attack leaders in corporate ...
(Date:12/7/2016)... ... December 07, 2016 , ... Delete® - Tattoo Removal and Laser Salon Offers ... Season. Save Up To 33% Off Botox® and Juvederm® Products Now Through December 31, ... with Delightful Deals on Botox® and Juvederm® just in time for the ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Research and Markets has announced the addition of the ... to 2021" report to their offering. ... , , The immunohistochemistry (IHC) ... a CAGR of 7.3% during the forecast period of 2016 to 2021. ... rapidly increasing geriatric population across the globe are the primary driving the ...
(Date:12/7/2016)... 7, 2016  Palatin Technologies, Inc. ("Palatin") (NYSE ... a previously disclosed underwritten public offering of units ... as sole book-running manager, Roth Capital Partners acted ... as co-manager for the offering. "This ... net proceeds, allowing us to continue advancing bremelanotide ...
(Date:12/7/2016)... , Dec. 7, 2016 DelveInsight,s, ... report provides in depth insights on the ... the Janus Kinase 3 (JAK3) Inhibitors. The ... various stages of development including Discovery, Pre-clinical, ... and Preregistration. Report covers the product clinical ...
Breaking Medicine Technology: