Navigation Links
Loyola researchers identify risk factor for life-threatening disease in preemies
Date:1/16/2014

Many premature infants suffer a life-threatening bowel infection called necrotizing enterocolitis (NEC).

Researchers at Loyola University Health System have identified a marker to identify those infants who are at risk for the infection, enabling doctors to employ early preventive strategies. These findings were published in the latest issue of the Journal of Pediatric Surgery.

"This information will allow us to better care for these premature infants," said Jonathan Muraskas, MD, study investigator and co-medical director of Loyola's neonatal ICU. "Simple changes to blood transfusion practices, feeding patterns and treatment of these infants may significantly reduce the incidence of NEC."

NEC is the most common serious gastrointestinal disorder among preterm newborns. It affects up to 10 percent of extremely low birth weight infants and has a mortality rate of nearly 30 percent. There is no known cause for the disease, yet researchers believe it may result from a combination of decreased blood flow to the bowel, feeding patterns, infection, mechanical injury or abnormal immune response.

NEC occurs when the lining of the intestinal wall dies and tissue falls off. Most cases of NEC are mild to moderate and can be successfully treated with antibiotics. But in severe cases, a hole can develop in the intestine, allowing bacteria to leak into the abdomen causing a life-threatening infection.

This study evaluated 177 infants born at less than 32 weeks' gestation and/or babies who were less than 3 pounds, 3 ounces. Blood samples were collected from these infants within 72 hours of birth and weekly for four weeks to measure reticulated platelets (RP) and intestinal alkaline phosphatase (iAP). Of the 177 infants, 15 (8.5 percent) developed NEC. Of these, 93 percent had low RP levels and 60 percent had high iAP. Those infants with low RP levels were significantly more likely to develop NEC while those with high iAP showed a similar trend.

"Decreased reticulated platelets serve as a sensitive indicator for NEC onset," Dr. Muraskas said. "Further research also may find that infants with elevated iAP levels may be at risk for this serious illness."


'/>"/>
Contact: Nora Dudley
nodudley@lumc.edu
708-216-6268
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Loyola receives Innovation Award for clinical research database
2. Loyola University New Orleans’ School of Nursing is Ranked Among Best Online Nursing Programs for Third Straight Year
3. Loyola bioethics study finds medical students concerned about desensitization to dying patients
4. Loyola neurologist is co-editor of 3-volume, 1,480-page guide to clinical neurology
5. Osteoporosis drugs compared for side effects, efficacy in Loyola study
6. Risk of osteoporosis drugs side effects not significant, Loyola researchers find
7. Loyola study assesses use of fingerstick blood sample with i-STAT point-of-care device
8. Loyola University New Orleans Hosts Newly Appointed U.S. Commerce Secretary
9. Loyola School of Nursing Online DNP Program Receives Federal Grant for Health Training
10. Loyola nuclear medicine technologist named National Technologist of the Year
11. Loyola receives $1.5 million grant to study vitamin D for diabetes and depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)...  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported ... required to build a strong and stable market for ... on the OTC Markets-pink current trading platform. ... are seeing an anomaly in market trading activities that ... the Company, but shareholders and market players as well. ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: