Navigation Links
Loyola researchers identify risk factor for life-threatening disease in preemies

Many premature infants suffer a life-threatening bowel infection called necrotizing enterocolitis (NEC).

Researchers at Loyola University Health System have identified a marker to identify those infants who are at risk for the infection, enabling doctors to employ early preventive strategies. These findings were published in the latest issue of the Journal of Pediatric Surgery.

"This information will allow us to better care for these premature infants," said Jonathan Muraskas, MD, study investigator and co-medical director of Loyola's neonatal ICU. "Simple changes to blood transfusion practices, feeding patterns and treatment of these infants may significantly reduce the incidence of NEC."

NEC is the most common serious gastrointestinal disorder among preterm newborns. It affects up to 10 percent of extremely low birth weight infants and has a mortality rate of nearly 30 percent. There is no known cause for the disease, yet researchers believe it may result from a combination of decreased blood flow to the bowel, feeding patterns, infection, mechanical injury or abnormal immune response.

NEC occurs when the lining of the intestinal wall dies and tissue falls off. Most cases of NEC are mild to moderate and can be successfully treated with antibiotics. But in severe cases, a hole can develop in the intestine, allowing bacteria to leak into the abdomen causing a life-threatening infection.

This study evaluated 177 infants born at less than 32 weeks' gestation and/or babies who were less than 3 pounds, 3 ounces. Blood samples were collected from these infants within 72 hours of birth and weekly for four weeks to measure reticulated platelets (RP) and intestinal alkaline phosphatase (iAP). Of the 177 infants, 15 (8.5 percent) developed NEC. Of these, 93 percent had low RP levels and 60 percent had high iAP. Those infants with low RP levels were significantly more likely to develop NEC while those with high iAP showed a similar trend.

"Decreased reticulated platelets serve as a sensitive indicator for NEC onset," Dr. Muraskas said. "Further research also may find that infants with elevated iAP levels may be at risk for this serious illness."

Contact: Nora Dudley
Loyola University Health System

Related medicine news :

1. Loyola receives Innovation Award for clinical research database
2. Loyola University New Orleans’ School of Nursing is Ranked Among Best Online Nursing Programs for Third Straight Year
3. Loyola bioethics study finds medical students concerned about desensitization to dying patients
4. Loyola neurologist is co-editor of 3-volume, 1,480-page guide to clinical neurology
5. Osteoporosis drugs compared for side effects, efficacy in Loyola study
6. Risk of osteoporosis drugs side effects not significant, Loyola researchers find
7. Loyola study assesses use of fingerstick blood sample with i-STAT point-of-care device
8. Loyola University New Orleans Hosts Newly Appointed U.S. Commerce Secretary
9. Loyola School of Nursing Online DNP Program Receives Federal Grant for Health Training
10. Loyola nuclear medicine technologist named National Technologist of the Year
11. Loyola receives $1.5 million grant to study vitamin D for diabetes and depression
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Smiles by Stevens is pleased to ... facial wrinkling. While many patients are aware of the benefits of Botox® in the ... to those suffering with discomfort, soreness, and pain as a result of Jaw Tension, ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, ... from Bronx, N.Y. “I thought there had to be a convenient and comfortable way ... , The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately ... has undertaken significant expansion of its current state of the art research, development ... PharmaTech’s strategy to increase its manufacturing capacity as well as to support its ...
(Date:11/25/2015)... San Mateo, CA (PRWEB) , ... November 25, 2015 , ... ... $15,000 in prizes were awarded to winners of the Create Real Impact awards. ... and creative expression to help stem the tide of distracted and reckless driving, the ...
(Date:11/24/2015)... , ... November 24, 2015 , ... New patients who ... a referral for dental implants at her Mississauga, ON practice. Dr. Williams ... in the placement of dental implants. , Missing teeth can lead to a ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and GE ... an agreement for DILON to distribute GE,s Discovery NM750b ... globe. The signing of this distribution agreement will provide Dilon,s ... Breast Imaging system and is considered an initial step ... healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... Sectra (STO: SECT B) announces that ... agreement to deploy Breast Imaging PACS in its ... Breast Center a future-proof platform capable of expanding with the ... that Breast Center of Acadiana has entered into ... in its two freestanding imaging centers. This investment will ...
(Date:11/24/2015)... --  HeartWare International, Inc . (NASDAQ: HTWR ), ... that are revolutionizing the treatment of advanced heart failure, ... Doug Godshall is scheduled to present at the ... December 1, 2015 at 3:00 p.m. ET.  The conference ... York . .  A ...
Breaking Medicine Technology: