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Lowering Blood Protein Won't Help Kidney Patients
Date:9/11/2007

. And, people with kidney disease also have significantly higher levels of vascular disease than the general population. Complications from vascular disease are so common in kidney patients that as many as one out of every five dies each year from vascular disease, according to the researchers.

Because of the association between homocysteine and vascular disease, Jamison's group hoped that if they could lower homocysteine levels, they could also reduce mortality and the rates of heart attack, stroke and amputations.

They enrolled more than 2,000 veterans at 36 Veterans Administration medical centers across the country. All had advanced chronic kidney disease or end-stage renal failure.

Half of the participants were given a placebo, and the other half were instructed to take a daily capsule that contained 40 milligrams (mg) folic acid, 100 mg vitamin B6 and 2 mg of vitamin B12.

The study lasted five years, and the average follow-up time was 3.2 years.

The vitamin therapy was successful in lowering homocysteine levels. Homocysteine went down almost 26 percent in the treatment group, but less than 2 percent in the placebo group.

However, those lowered levels did not translate into saved lives. In total, 448 people from the vitamin group and 436 people in the placebo group died during the study -- statistically nearly equal. Additionally, the researchers found no statistically significant differences in the rates of heart attack, stroke and amputation.

While this study wasn't designed to determine why lowering homocysteine levels was ineffective in preventing deaths and disease, Jamison said there are several possibilities. "One is that homocysteine is a marker of vascular disease, rather than a cause of it. Another is that the vascular burden in these patients may be too great. It may be that we started too late to make a difference in these patients."

Dr. Robert Provenzano, chief
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