Navigation Links
Lower-dose fractionated stereotactic radiotherapy results in better hearing preservation
Date:12/17/2008

(PHILADELPHIA) Researchers at Thomas Jefferson University have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy. The study appeared online in the International Journal of Radiation Oncology*Biology*Physics.

"We previously had not determined the optimal dose of fractionated stereotactic radiotherapy for acoustic neuromas," said David W. Andrews, M.D., professor and vice-chairman of the Department of Neurological Surgery at Jefferson Medical College of Thomas Jefferson University, and the lead author. "This study was designed to compare the hearing preservation between the two doses. The lower-dose treatment resulted in a 100 percent tumor control rate, with the advantage of better hearing preservation."

Between 1994 and 2007, 101 patients with serviceable hearing were treated at Jefferson with fractionated stereotactic radiotherapy (FSR). Dr. Andrews and colleagues analyzed 89 patients within that cohort who had complete audiometric data available. Forty-three patients had received the high-dose of 50.4 Gruyere (Gy). Forty-six patients received the low-dose of 46.8 Gy.

The tumor local control rates were 100% for both the lower-dose cohort and the higher-dose cohort. The pure tone average was 33 decibels (dB) in the lower-dose cohort, which was significantly better than the 40 dB pure tone average in the high-dose cohort. The actuarial hearing preservation rate was also longer in the lower-dose cohort: 165 weeks vs. 79 weeks.

"This is a potentially practice-changing finding," Dr. Andrews said. "We are now working to design a study to directly compare FSR with other treatment options, including stereotactic single fraction radiosurgery."

According to Dr. Andrews, the tumor control rates for FSR are comparable to those of stereotactic single fraction radiosurgery, another treatment option for acoustic neuromas. But Dr. Andrews and colleagues found in a previous study that FSR preserves hearing better, and does not cause trigeminal or facial neuropathies.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
2. BrainLAB Announces 510(k) FDA Clearance of Monte Carlo Dose Engine for Stereotactic Radiosurgery and Radiation Therapy
3. IAME Goes Live With New Stereotactic Breast Program
4. ESF workshop makes major advance in cancer radiotherapy
5. Central California Doctors Now Using Fast RapidArc(TM) Radiotherapy Technology to Battle Cancer
6. Cancer Patients in Southeastern Florida Now Benefiting From RapidArc(TM) Radiotherapy Treatments
7. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
8. Varian Medical Systems Signs Collaboration Agreement to Bring Advanced Radiotherapy Equipment to Indonesia
9. Decatur Memorial Hospital Becomes First in Illinois to Treat Cancer Patients With RapidArc(TM) Radiotherapy Technology
10. Modulated radiotherapy can cut treatment time for cancer of the rectum without increasing toxicity
11. Elekta Launches Web-based Virtual Clinic, Offers Better Understanding of Radiotherapy Solutions for the Treatment of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... February 08, 2016 , ... Delta Dental of California and its affiliated ... , Gary D. Radine, who recently retired as president and CEO of Delta Dental ... 2015 CEO of the Year , helped lead the effort to raise funds for ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... of organizations. DocuSyst provides a cloud hosted environment for FileHold software that ... integration with various 3rd party applications using the FileHold web services API. DocuSyst ...
(Date:2/8/2016)... ... 08, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to a ... derived from a cluster of melanin when exposed to sunlight. Although most moles are ... lifetime of embarrassment. Historically, mole removal has involved a painful, often expensive ...
(Date:2/8/2016)... ... , ... According to research by the National Association of ... be certified or obtain continuing education. To increase patient awareness of the lack ... campaign to inform dentists and patients about the possible lack of skills and ...
(Date:2/7/2016)... , ... February 07, 2016 , ... ... Facial Plastics, has added Kybella® to his medical and surgical expertise. Technically known ... approved FDA injectable medication used as a non-surgical alternative for reduction of fat ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... HEIGHTS, Utah , Feb. 8, 2016 /PRNewswire/ ... and distributor of advanced-technology medical devices and rehabilitation ... related markets, congratulates the Denver Broncos, football team ... Kelvyn H. Cullimore Jr. , Chairman and Chief ... of excellence and we look forward to enhancing ...
(Date:2/8/2016)... 2016 --> ... Allied Market Research titled, "World Synthetic Biology ... estimates the world synthetic biology market to be ... technology segment would continue to lead the market ... collectively, held around half of the market share ...
(Date:2/5/2016)... OAKS, Calif. , Feb. 5, 2016 Amgen ... 5 th Annual Global Healthcare Conference at 9:15 a.m. ... York City . David W. Meline , executive ... at the conference. Live audio of the presentation can be ... , under Investors. A replay of the webcast will also ...
Breaking Medicine Technology: