Navigation Links
Lower-dose fractionated stereotactic radiotherapy results in better hearing preservation
Date:12/17/2008

(PHILADELPHIA) Researchers at Thomas Jefferson University have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy. The study appeared online in the International Journal of Radiation Oncology*Biology*Physics.

"We previously had not determined the optimal dose of fractionated stereotactic radiotherapy for acoustic neuromas," said David W. Andrews, M.D., professor and vice-chairman of the Department of Neurological Surgery at Jefferson Medical College of Thomas Jefferson University, and the lead author. "This study was designed to compare the hearing preservation between the two doses. The lower-dose treatment resulted in a 100 percent tumor control rate, with the advantage of better hearing preservation."

Between 1994 and 2007, 101 patients with serviceable hearing were treated at Jefferson with fractionated stereotactic radiotherapy (FSR). Dr. Andrews and colleagues analyzed 89 patients within that cohort who had complete audiometric data available. Forty-three patients had received the high-dose of 50.4 Gruyere (Gy). Forty-six patients received the low-dose of 46.8 Gy.

The tumor local control rates were 100% for both the lower-dose cohort and the higher-dose cohort. The pure tone average was 33 decibels (dB) in the lower-dose cohort, which was significantly better than the 40 dB pure tone average in the high-dose cohort. The actuarial hearing preservation rate was also longer in the lower-dose cohort: 165 weeks vs. 79 weeks.

"This is a potentially practice-changing finding," Dr. Andrews said. "We are now working to design a study to directly compare FSR with other treatment options, including stereotactic single fraction radiosurgery."

According to Dr. Andrews, the tumor control rates for FSR are comparable to those of stereotactic single fraction radiosurgery, another treatment option for acoustic neuromas. But Dr. Andrews and colleagues found in a previous study that FSR preserves hearing better, and does not cause trigeminal or facial neuropathies.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
2. BrainLAB Announces 510(k) FDA Clearance of Monte Carlo Dose Engine for Stereotactic Radiosurgery and Radiation Therapy
3. IAME Goes Live With New Stereotactic Breast Program
4. ESF workshop makes major advance in cancer radiotherapy
5. Central California Doctors Now Using Fast RapidArc(TM) Radiotherapy Technology to Battle Cancer
6. Cancer Patients in Southeastern Florida Now Benefiting From RapidArc(TM) Radiotherapy Treatments
7. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
8. Varian Medical Systems Signs Collaboration Agreement to Bring Advanced Radiotherapy Equipment to Indonesia
9. Decatur Memorial Hospital Becomes First in Illinois to Treat Cancer Patients With RapidArc(TM) Radiotherapy Technology
10. Modulated radiotherapy can cut treatment time for cancer of the rectum without increasing toxicity
11. Elekta Launches Web-based Virtual Clinic, Offers Better Understanding of Radiotherapy Solutions for the Treatment of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... Sabah Shah MD, MBA has joined the Retina Group ... New York was founded by James M. Maisel, MD and has been providing tertiary medical ... always followed a legacy of surpassing expectations amongst her peers. Growing up in a ...
(Date:12/5/2016)... (PRWEB) , ... December 05, ... ... professional calibrations is an excellent way to ensure moisture measurements are consistently ... time-consuming and impractical. , Now, METTLER TOLEDO offers a solution: ...
(Date:12/5/2016)... ... 05, 2016 , ... A newly released study has found ... and accuracy of placing precordial electrodes with little cognitive effort and a high ... years, studies have shown that single electrode misplacement is one of the single ...
(Date:12/4/2016)... California (PRWEB) , ... December 03, 2016 , ... ... lower thirds, 4 transitions and many more tools allowing FCPX editors to create ... of Pixel Film Studios. , Perfect Harmony contains a beautifully designed 3D ...
(Date:12/4/2016)... Dallas, TX (PRWEB) , ... December 03, 2016 ... ... of the “Fastest growing Entrepreneurial Company in the Dallas area” Tuesday evening at ... the Omni Dallas Hotel, presented by SMU's Cox School’s Caruth Institute for Entrepreneurship. ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016 Sanovas, Inc., a life science ... launch of its wholly owned subsidiary, Intubation Science, Inc., and ...   Logo - http://photos.prnewswire.com/prnh/20161202/445251LOGO   ... Sanovas, Inc. ... There are over 40 million Endotracheal ...
(Date:12/5/2016)... , Dec. 5, 2016  Recently Zymo ... methylation age predictor, known as Horvath,s Clock. Based ... a sample analysis service to academic and biopharma ... any human sample, other than sperm. The ... accurately estimate biological age versus chronological age following ...
(Date:12/5/2016)... Dec. 5, 2016  BD (Becton, Dickinson and Company) ... technology company, will demonstrate an enhanced technology platform designed ... including the company,s leading Pyxis™ and Alaris™ systems, at ... 2016 Midyear Meeting being held in ... While national data show that approximately 68 percent of ...
Breaking Medicine Technology: