Navigation Links
Lower-dose fractionated stereotactic radiotherapy results in better hearing preservation
Date:12/17/2008

(PHILADELPHIA) Researchers at Thomas Jefferson University have found that a lower dose of fractionated stereotactic radiotherapy for acoustic neuromas results in better hearing preservation and has the same tumor local control rate as a higher dose of therapy. The study appeared online in the International Journal of Radiation Oncology*Biology*Physics.

"We previously had not determined the optimal dose of fractionated stereotactic radiotherapy for acoustic neuromas," said David W. Andrews, M.D., professor and vice-chairman of the Department of Neurological Surgery at Jefferson Medical College of Thomas Jefferson University, and the lead author. "This study was designed to compare the hearing preservation between the two doses. The lower-dose treatment resulted in a 100 percent tumor control rate, with the advantage of better hearing preservation."

Between 1994 and 2007, 101 patients with serviceable hearing were treated at Jefferson with fractionated stereotactic radiotherapy (FSR). Dr. Andrews and colleagues analyzed 89 patients within that cohort who had complete audiometric data available. Forty-three patients had received the high-dose of 50.4 Gruyere (Gy). Forty-six patients received the low-dose of 46.8 Gy.

The tumor local control rates were 100% for both the lower-dose cohort and the higher-dose cohort. The pure tone average was 33 decibels (dB) in the lower-dose cohort, which was significantly better than the 40 dB pure tone average in the high-dose cohort. The actuarial hearing preservation rate was also longer in the lower-dose cohort: 165 weeks vs. 79 weeks.

"This is a potentially practice-changing finding," Dr. Andrews said. "We are now working to design a study to directly compare FSR with other treatment options, including stereotactic single fraction radiosurgery."

According to Dr. Andrews, the tumor control rates for FSR are comparable to those of stereotactic single fraction radiosurgery, another treatment option for acoustic neuromas. But Dr. Andrews and colleagues found in a previous study that FSR preserves hearing better, and does not cause trigeminal or facial neuropathies.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. Grupo IMO Hosts Symposium on Use of TomoTherapy for Stereotactic Radiosurgery and Stereotactic Body Radiation Procedures : Experts Detail HiArt Platform Advantages for Treatment of Brain, Lung, Pancreatic and Metastatic Cancers
2. BrainLAB Announces 510(k) FDA Clearance of Monte Carlo Dose Engine for Stereotactic Radiosurgery and Radiation Therapy
3. IAME Goes Live With New Stereotactic Breast Program
4. ESF workshop makes major advance in cancer radiotherapy
5. Central California Doctors Now Using Fast RapidArc(TM) Radiotherapy Technology to Battle Cancer
6. Cancer Patients in Southeastern Florida Now Benefiting From RapidArc(TM) Radiotherapy Treatments
7. Clinicians in Netherlands Treat Lung Cancer Patients Using New RapidArc Radiotherapy Technology from Varian Medical Systems
8. Varian Medical Systems Signs Collaboration Agreement to Bring Advanced Radiotherapy Equipment to Indonesia
9. Decatur Memorial Hospital Becomes First in Illinois to Treat Cancer Patients With RapidArc(TM) Radiotherapy Technology
10. Modulated radiotherapy can cut treatment time for cancer of the rectum without increasing toxicity
11. Elekta Launches Web-based Virtual Clinic, Offers Better Understanding of Radiotherapy Solutions for the Treatment of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
Breaking Medicine Technology: