Navigation Links
Lower antioxidant level might explain higher skin-cancer rate in males
Date:12/1/2011

COLUMBUS, Ohio Men are three times more likely than women to develop a common form of skin cancer but medical science doesn't know why. A new study may provide part of the answer.

Researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) have found that male mice had lower levels of an important skin antioxidant than female mice and higher levels of certain cancer-linked inflammatory cells.

The antioxidant, a protein called catalase, inhibits skin cancer by mopping up hydrogen peroxide and other DNA-damaging reactive-oxygen compounds that form during exposure to ultraviolet B light (UVB), a common source of sunburn and cancer-causing skin damage. Studies by others have linked low catalase activity to skin cancer progression.

The research is published online in the Journal of Investigative Dermatology.

The findings suggest that women may have more natural antioxidant protection in the skin than men, say study co-leaders Gregory Lesinski and Tatiana Oberyszyn, both of the OSUCCC James.

"As a result, men may be more susceptible to oxidative stress in the skin, which may raise the risk of skin cancer in men compared to women," says Lesinski, an assistant professor of molecular virology, immunology and medical genetics and a member of the OSUCCC James Innate Immunity Program.

The study also found that UVB exposure caused a unique inflammatory white blood cell population called 'myeloid-derived suppressor cells' to migrate from the bone marrow into the exposed skin. Furthermore, higher numbers of these cells moved into the skin of male mice than female mice.

"To our knowledge, we've shown for the first time that UVB exposure causes a migration of systemic myeloid-derived suppressor cells, and it suggests that these cells might be a novel source of UVB-induced immune suppression," says first author Nicholas Sullivan, a resea
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Drinking Milk While Pregnant May Lower Kids MS Risk
3. Dark Chocolate May Lower Stroke Risk
4. Can Chocolate Lower Your Risk of Stroke?
5. Chocolate lovers could be lowering their risk of stroke: Study
6. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
7. Olde Towne Gaithersburg Welcomes Thibadeau Mortuary - A Lower-Cost Alternative In Funeral and Cremation Service
8. Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case
9. Successful treatment of periodontal disease lowered preterm birth incidences
10. Certain Bone Drugs May Lower Breast Cancer Risk
11. Congressional Concession On Medical Malpractice Awards Will Not Lower Health Care Costs And Will Hurt Patients' Rights, Washington, DC Attorney Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 As transvaginal mesh ... Johnson & Johnson’s Ethicon Inc. unit continue to ... that the Texas Attorney General’s Office has acknowledged ... surgical mesh products used to treat pelvic organ ... report from kens5.com, the probe began nearly two ...
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July 10, 2014 ... was thought to be cured by immediate and aggressive drug ... the AIDS-causing virus in her bloodstream, disappointed federal officials announced ... had remained virus-free even though she stopped taking HIV medications ... remission would open the door to a functional cure for ...
(Date:7/11/2014)... The report, “Specialty Synthetic Fibers & ... - 2018,” defines and segments the specialty synthetic ... and forecast of the volumes and values of ... meta aramids, UHMW Polyethylene, carbon fiber, partially oxidized ... fiber, PBO fiber, and liquid crystal polymer fiber ...
(Date:7/11/2014)... 11, 2014 Operators and ... billion in fuel costs now that model ... current GHG standards are phasing in ... upon themselves to install new features into ... reduction technologies , 2.    Efficient driveline components which ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Ticket Down ... at the Concord Pavilion . When it comes to the ... Luke Bryan. The 37-year-old Georgia native is one of the biggest ... the entertainment business. Bryan is currently out on his “That’s My ... the many stops the tour will be making through the rest ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 2Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 3Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3
... Oct. 8 Thousands of people around the world ... poetry and speak out to raise awareness and funds ... on Saturday, October 10, 2009. , "Discovering your Voice," ... 2009, stresses the need to hear the voices of ...
... Quantros, a leading provider of safety and quality ... industry, today announced significant updates to its Regulatory ... coincide with National Hospital Quality Measures (NHQM) updates ... will now include expanded tracking of venous thromboembolism ...
... Sysmex America, Inc. today announced that Tom Lindsay ... Sales. Lindsay will be responsible for sales strategy ... and retention of the company,s sales professionals. ... will focus on cross-functional collaboration that enables Sysmex to ...
... 8 American Laser Centers, the leading provider of aesthetic ... CEO, to oversee the continued growth and national expansion of ... ALC,s board of managers, and is responsible for the strategic ... the role of CEO from James McDermott. , American Laser ...
... The University of Guam received an $8,000,000 five-year ... to support a strong national cancer program aimed ... and the impact on minority populations. The grant ... research capabilities at the University of Guam, Increase ...
... Elsevier, a world-leading publisher of medical information products and ... Medical Press (PUMP) it has donated over 5,000 books ... The initiative is supported by the Development Centre for ... book donation is in line with the spirit of ...
Cached Medicine News:Health News:Discovering the Voice of Hospice and Palliative Care Worldwide: World Hospice and Palliative Care Day - October 10, 2009 2Health News:Quantros Expands RRM Solution With New Quality Measures 2Health News:Sysmex America Names National Sales Director 2Health News:American Laser Centers Names Health Care Veteran Steven Straus CEO 2Health News:University of Guam Cancer Research Center receives $8M grant 2Health News:Elsevier's Health Sciences Division and Peking University Medical Press cooperate on book donation 2
(Date:7/11/2014)... /PRNewswire-iReach/ -- VAPETEK™, Inc. has announced a new ... in portable vaporizers, which contains CBD, or cannabodiol. ... cannabidiol offers consumers a THC-free product made for ... technology. Photo - http://photos.prnewswire.com/prnh/20140711/126344 ... compounds which are currently known, two of which ...
(Date:7/11/2014)... 11, 2014 Patient engagement has become ... organizations are turning to an assortment of marketing ... part of this evolving approach to patient engagement, ... and engage patients throughout their experiences with a ... By mapping the patient journey and employing a ...
(Date:7/11/2014)... , July 11, 2014 The ... are evolving across industry sectors to better identify ... better ways to engage with and understand consumers, ... themselves and make critical purchasing decisions. ... Best Practices, LLC, one area where organizations can ...
Breaking Medicine Technology:VAPETEK Releases CBD-Infused eLiquid For The Consumer Market 2New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2New Technologies Transforming Consumer Marketing Research Playbook 2
... treatment initiation and longer exposure to Betaseron ... sclerosis, MONTREAL, Sept. 19 Data ... Research in Multiple Sclerosis (WCTRIMS) demonstrated that,early ... a,greater impact on long-term outcomes, when compared ...
... 19 Novavax, Inc.,(Nasdaq: NVAX ) a clinical-stage ... Chief Executive Officer, will be presenting at,the 2008 UBS ... is being held September 22-25, 2008 at The Grand ... 2008 at 10:30 am.,Eastern Time. Dr. Singhvi will provide ...
Cached Medicine Technology:New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R) 2New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R) 3New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R) 4New Data Presented at WCTRIMS* Supports the Importance of Early and Sustained Treatment with Betaseron(R) 5
... to use instruments for nerve location: our ... stimulator, and muscle locator, together with a ... pencil point needles., ,The RDG Nerve ... to use stimulator, designed to facilitate the ...
... Based on the original MS-III ... electrosurgery certification, enhanced keypad ... ,The MiniStim® MS-IV peripheral ... for neuromuscular monitoring in operating ...
... beyond your investment., ,The Centiva/5 Critical Care ... time demands of the critical care environment. The ... mind combining a compact size with high levels ... valuable space around the patients bed and allows ...
... is combining a lightweight mesh material with the ... hernia plug which stands for a high patient ... material is included in Premilene Mesh LP Self-Forming ... for a softer and less bulky Plug Premilene ...
Medicine Products: