Navigation Links
Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
Date:4/3/2012

ROCHESTER, Minn. -- Add lower gastrointestinal (GI) problems such as ulcers, bleeding and perforations to the list of serious complications facing many rheumatoid arthritis patients. They are at greater risk for GI problems and gastrointestinal-related death than people without the disease, a Mayo Clinic study shows. Researchers say their findings point out the need for new ways to prevent and treat lower GI disease in rheumatoid arthritis patients; the incidence of lower gastrointestinal complications is rising even as upper GI problems decrease significantly among rheumatoid arthritis patients.

Smoking, the use of steroids known as glucocorticoids, prior upper GI disease and abdominal surgery were associated with lower GI problems in rheumatoid arthritis patients, the study found. The research was published online this week in The Journal of Rheumatology.

Rheumatologists have long recognized that rheumatoid arthritis patients are at higher risk for upper GI problems such as stomach ulcers and bleeding. The study suggests increased awareness of that and likely, modern treatment strategies that emphasize the need to prevent ulcers and bleeding and control rheumatoid arthritis without relying as much on nonsteroidal drugs and corticosteroids have reduced upper GI complications, says co-author Eric Matteson, M.D., Chair of the Department of Rheumatology at Mayo Clinic in Rochester.

"What we are also seeing for the first time in a systematic way is that patients with rheumatoid arthritis also are at risk for problems of bleeding and ulcers in the lower gut, especially the colon," Dr. Matteson says.

Lung disease, heart problems, osteoporosis and carpal tunnel syndrome are among other potential complications for patients with rheumatoid arthritis, an often debilitating disorder in which the immune system attacks tissues, inflaming joints. To study the incidence of GI problems in rheumatoid arthritis patients, Mayo researchers identified 813 patients with rheumatoid arthritis and 813 without it, using data from 1980-2008 in the Rochester Epidemiology Project, a National Institutes of Health-supported effort in which Mayo and other Olmsted County, Minn., health care providers pool medical records.

The incidence of upper GI problems in rheumatoid arthritis patients declined over the years but was still higher in that group: 2.9 for every 100 person years compared with 1.7 in non-rheumatoid arthritis patients. The rate of lower GI problems in rheumatoid arthritis patients was 2.1, compared with 1.4 in others, the study found. Of the arthritis patients studied, 229 died. GI problems were significantly associated with their deaths, including bleeds, perforations and obstructions.

"Our findings emphasize that physicians and patients must be vigilant for these complications, which can occur without causing abdominal pain," Dr. Matteson says. "Especially stopping smoking and reducing the use of corticosteroids would appear to be important in reducing the risk of major lower GI complications."


'/>"/>

Contact: Sharon Theimer
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
2. Drinking Milk While Pregnant May Lower Kids MS Risk
3. Dark Chocolate May Lower Stroke Risk
4. Can Chocolate Lower Your Risk of Stroke?
5. Chocolate lovers could be lowering their risk of stroke: Study
6. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
7. Olde Towne Gaithersburg Welcomes Thibadeau Mortuary - A Lower-Cost Alternative In Funeral and Cremation Service
8. Prominent New York City Real Estate Investor, Attorney and Atlanta Nursing Home Chains Pay $14 Million to Settle Whistleblower Kickback Case
9. Successful treatment of periodontal disease lowered preterm birth incidences
10. Certain Bone Drugs May Lower Breast Cancer Risk
11. Congressional Concession On Medical Malpractice Awards Will Not Lower Health Care Costs And Will Hurt Patients' Rights, Washington, DC Attorney Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... June 26, 2017 , ... ... is revolutionizing the way women look and feel about themselves and their sexual ... female sexual dysfunction and urinary leakage head on with a ground breaking medical ...
(Date:6/26/2017)... Antonio, TX (PRWEB) , ... June 26, 2017 ... ... physicians, their coding staff, and consumers are seeing lots of red these days. ... receive contain inaccurate charges that result from medical coding errors(1). Some studies point ...
(Date:6/26/2017)... Fitchburg, WI (PRWEB) , ... June 26, 2017 , ... ... implant consultations from Dr. Angela Cotey, with or without a referral. Dr. Cotey is ... the benefits of this preferred tooth replacement option. , Patients with missing teeth in ...
(Date:6/25/2017)... Viejo, CA (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric music ... presets above footage and sound in the timeline and write in the lyrics to any ... before flying back out. Each line of the text can be added modularly for optimal ...
(Date:6/25/2017)... ... 25, 2017 , ... An increase in wetter weather in the Northern California ... with that; a humdinger of an allergy season. A relief from drought conditions is ... misery-causing grass and weed pollen. , “Our patients have been reporting the typical ...
Breaking Medicine News(10 mins):
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
(Date:5/30/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will present at ... on Tuesday, June 13, 2017, in Rancho Palos ... and chief executive officer, is scheduled to present at 3:20 ... be accessed at http://ir.hill-rom.com/events.cfm . A recorded replay will ... through September 13, 2017. ...
(Date:5/26/2017)... Calif. , May 25, 2017  In response ... States , Direct Relief is working with Pfizer ... Naloxone available at no cost to community health centers, ... nonprofit providers nationwide. "Pfizer has a ... to medicines and ensuring patient safety through educational activities," ...
Breaking Medicine Technology: