Navigation Links
Low vitamin D levels may increase risk of Type 1 diabetes
Date:2/4/2013

Boston, MA Having adequate levels of vitamin D during young adulthood may reduce the risk of adult-onset type 1 diabetes by as much as 50%, according to researchers at Harvard School of Public Health (HSPH). The findings, if confirmed in future studies, could lead to a role for vitamin D supplementation in preventing this serious autoimmune disease in adults. The study was published online February 3, 2013 and will appear in the March 1 print edition of the American Journal of Epidemiology.

"It is surprising that a serious disease such as type 1 diabetes could perhaps be prevented by a simple and safe intervention," said lead author Kassandra Munger, research associate in the Department of Nutrition at HSPH.

This study provides the strongest findings to date to suggest that vitamin D may be protective against type 1 diabetes.

In type 1 diabetes (once called juvenile-onset or insulin-dependent diabetes), the body's immune system attacks and permanently disables the insulin-making cells in the pancreas. About 5% of the estimated 25.8 million people in the United States with diabetes have type 1, according to the American Diabetes Association. Although it often starts in childhood, about 60% of type 1 diabetes cases occur after age 20.

Previous studies have suggested that a shortage of vitamin D might boost type 1 diabetes risk, although those studies mostly examined the link between vitamin D levels in pregnancy or childhood and the risk of type 1 diabetes in children. Other research, in young adults, uncovered an association between high vitamin D levels and a lowered risk of multiple sclerosisan autoimmune disease genetically and epidemiologically related to type 1 diabetessuggesting that inadequate vitamin D in adulthood may be an important risk factor for autoimmune diseases in general.

Long-term study of military personnel

The researchers conducted a prospective case-control study of U.S. military personnel on active duty, using blood samples from the Department of Defense Serum Repository, which contains more than 40 million samples collected from 8 million military personnel since the mid-1980s. Identifying 310 individuals diagnosed with type 1 diabetes between 1997 and 2009, the team examined blood samples taken before onset of the disease, and compared the samples with those of 613 people in a control group.

The researchers found that white, non-Hispanic, healthy young adults with higher serum levels (>75 nmol/L) of vitamin D had about half the risk of developing type 1 diabetes than those with the lowest levels of vitamin D (<75 nmol/L). Although the researchers found no significant association among Hispanics and blacks, the authors said this may be due to the small number of individuals in these groups.

"The risk of type 1 diabetes appears to be increased even at vitamin D levels that are commonly regarded as normal, suggesting that a substantial proportion of the population could benefit from increased vitamin D intake," said Alberto Ascherio, professor of epidemiology and nutrition at HSPH, the study's senior author.

About vitamin D

Worldwide, an estimated 1 billion people have inadequate levels of vitamin D in their blood, and deficiencies can be found in all ethnicities and age groups. While sun exposure is an excellent source of vitamin D, sunscreen, clothing, skin pigmentation, and winter months reduce vitamin D production. Food tends to be a poor source of vitamin D, with "good" sources, such as salmon and fortified milk, containing 400IU or less per serving. "Whereas it is premature to recommend universal use of vitamin D supplements for prevention of type 1 diabetes, the possibility that many cases could be prevented by supplementation with 1,000-4,000 IU/day, which is largely considered safe, is enticing," the authors said.


'/>"/>

Contact: Marge Dwyer
mhdwyer@hsph.harvard.edu
617-432-8416
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. Vitamin E in diet protects against many cancers
2. Researchers determine vitamin D blood level for reducing major medical risks in older adults
3. Vitamin K2: New hope for Parkinsons patients?
4. Experts call for clinical trials to test non-skeletal benefits of vitamin D
5. Vitamin D + TB vaccine: Allies in fight against bladder cancer?
6. Vitamin C improves pulmonary function in newborns of pregnant smoking women
7. Vitamin C improves lung function in newborns of pregnant smoking women
8. Japanese-American Men With Low Vitamin-D Diet Face Higher Stroke Risk
9. Too much vitamin D can be as unhealthy as too little
10. Older adults may need more vitamin D to prevent mobility difficulties
11. Older Women Should Not Take Calcium, Vitamin D: Task Force
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... W.S. ... products, has been honored with a 2016 When Work Works Award for its use ... part of the national When Work Works project administered by the Families and Work ...
(Date:5/26/2016)... ... , ... Connor Sports, through its Connor Cares initiative, will continue ... Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career and ... forms and levels of the game, Connor Sports has committed to a significantly increased ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are nearly 14.5 million people living with ... worldwide. On Sunday, June 5, 2016, communities around the world will gather to recognize ... , National Cancer Survivors Day® is an annual worldwide Celebration of Life that is ...
(Date:5/26/2016)... ... May 26, 2016 , ... An April Gallup survey found rising health care ... of Sun Health Senior Living (SHSL) may not share those same worries ... prescription copays for the year, while holding the line on increasing their contributions, including ...
(Date:5/26/2016)... ... 26, 2016 , ... Eating Recovery Center, Washington ... a brand new child and adolescent residential treatment center on June 1. The ... more specialized eating disorder treatment and access to life-saving care. , To celebrate, ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 Cirujanos holandeses han ... a los médicos a compartir sus mejores prácticas por ... mundial. Profesionales médicos de Europa, África, Asia ... a la aplicación, que combina la transmisión en vivo ... seguro. Educación   "Imagine un médico ...
(Date:5/24/2016)... 2016   , Study ... overall bowel cleansing and superiority in , ... of the ascending colon ... Norgine B.V. today announced new positive data from the ... bowel preparation) versus standard 2 litre PEG with ascorbate. The study ...
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
Breaking Medicine Technology: