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Low vitamin D levels may increase risk of Type 1 diabetes
Date:2/4/2013

Boston, MA Having adequate levels of vitamin D during young adulthood may reduce the risk of adult-onset type 1 diabetes by as much as 50%, according to researchers at Harvard School of Public Health (HSPH). The findings, if confirmed in future studies, could lead to a role for vitamin D supplementation in preventing this serious autoimmune disease in adults. The study was published online February 3, 2013 and will appear in the March 1 print edition of the American Journal of Epidemiology.

"It is surprising that a serious disease such as type 1 diabetes could perhaps be prevented by a simple and safe intervention," said lead author Kassandra Munger, research associate in the Department of Nutrition at HSPH.

This study provides the strongest findings to date to suggest that vitamin D may be protective against type 1 diabetes.

In type 1 diabetes (once called juvenile-onset or insulin-dependent diabetes), the body's immune system attacks and permanently disables the insulin-making cells in the pancreas. About 5% of the estimated 25.8 million people in the United States with diabetes have type 1, according to the American Diabetes Association. Although it often starts in childhood, about 60% of type 1 diabetes cases occur after age 20.

Previous studies have suggested that a shortage of vitamin D might boost type 1 diabetes risk, although those studies mostly examined the link between vitamin D levels in pregnancy or childhood and the risk of type 1 diabetes in children. Other research, in young adults, uncovered an association between high vitamin D levels and a lowered risk of multiple sclerosisan autoimmune disease genetically and epidemiologically related to type 1 diabetessuggesting that inadequate vitamin D in adulthood may be an important risk factor for autoimmune diseases in general.

Long-term study of military personnel

The researchers conducted a prospective case-control study of U.
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Contact: Marge Dwyer
mhdwyer@hsph.harvard.edu
617-432-8416
Harvard School of Public Health
Source:Eurekalert

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