Navigation Links
Low vitamin D levels do not increase the risk of chronic obstructive pulmonary disease
Date:11/3/2011

Vitamin D levels are not related to acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with severe COPD, according to a large prospective cohort study involving 973 North American patients. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the study, a secondary analysis of data from a randomized, controlled trial of the effects of azithromycin on the frequency of AECOPD, no relationship was found between baseline Vitamin D levels and time to first AECOPD or between vitamin D levels and AECOPD exacerbation rates.

"Vitamin D insufficiency and deficiency are common in patients with COPD, and patients with severe COPD are at the highest risk for exacerbations, so we hypothesized that low vitamin D levels might increase the risk of AECOPDs," said Ken M. Kunisaki, M.D., of the Minneapolis Veterans Affairs Medical Center. "Our negative results are in contrast with earlier studies in which lower vitamin D levels were associated withhigher rates of respiratory infections in adults and more frequent asthma exacerbations in children."

In the current study, mean forced expiratory volume in one second (FEV1) was 1.12L, 40% of predicted. Mean vitamin D level at baseline was 25.7 12.8 ng/mL, with 33.1% of subjects categorized as vitamin D insufficient (≥20 ng/mLbut <30 ng/mL), 32.0% as vitamin D deficient (<20 ng/mL) and 8.4% as having severe vitamin D deficiency (<10 ng/mL).AECOPDs were defined as a complex of respiratory symptoms (increased or new-onset) of at least 1 of thefollowing: cough, sputum, wheezing, dyspnea, or chest tightness with a durationof at least 3 days and requiring treatment with an antibiotic or systemiccorticosteroid.

During 1 year of follow-up, study subjects experienced a total of 1415 AECOPDs. Of 973 patients,360 (37%)remained AECOPD-free, 278 (29%) had 1 AECOPD, 133 (14%)had 2 AECOPDs, and 202 (21%) had 3 or moreAECOPDs.

In the primary analysis, vitamin D levels had no relationship to time to first AECOPD; for a 10 ng/mL increment in vitamin D level, the estimated hazard ratio was 1.04 (95% confidence interval: 0.97-1.12). In secondary analyses, vitamin D levels were not related to annualized rates of AECOPDs in either Poisson (p=0.82)or negative binomial analyses (p=0.87).

Patients with severe vitamin D deficiency had a higher mean rateof AECOPDs, but this difference was not statistically significant. Patients with severe vitamin D deficiency did not exhibit faster time to first AECOPD than other patients.

The study had some limitations. Vitamin D levels were only assessed at baseline, and so may have changed during the study period. Seasonal changes in vitamin D levels may also have occurred.

"Contrary to what we expected, baseline vitamin D levelswere not related to the risk of subsequent AECOPDs in this large group of COPD patients at high risk of AECOPD," Dr. Kunisaki said. "Vitamin D supplementation is unlikely to have an effect on AECOPD risk in these patients."


'/>"/>
Contact: Nathanial Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Caucasians who avoid sun exposure more likely to be vitamin D deficient, Stanford study suggests
2. Low vitamin D common in spine surgery patients
3. Vitamin B-based treatment for corneal disease may offer some patients a permanent solution
4. Women do not get enough vitamin D during the menopause
5. Research Sheds Light on Vitamin Ds Role in Immunity
6. Extra Vitamin E May Be Associated With Prostate Cancer
7. National study finds vitamin E supplement may increase prostate cancer risk
8. Oral steroids linked to severe vitamin D deficiency in nationwide study
9. Could Too Little Vitamin B-12 Shrink the Aging Brain?
10. Many Black Men in Cold Climates Lack Vitamin D
11. Vitamin D deficiency linked with airway changes in children with severe asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... ... in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation ... providing proof of successfully certified products, services and staff. , Validation Center is ...
(Date:5/26/2016)... , ... May 26, 2016 , ... W.S. Badger ... has been honored with a 2016 When Work Works Award for its use of ... of the national When Work Works project administered by the Families and Work Institute ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University College ... academic programs. , Answering to the increasing demand for curricular specializations, the Certificate ... and environmental and land use law. ,  , “The demand for lawyers with ...
(Date:5/26/2016)... ... 2016 , ... The Woodlands at John Knox Village , Florida’s first ... for living and healing, celebrated its grand opening, today. The Woodlands at John Knox ... by Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line of ... Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than 100 ... government agencies, including NASA. , In 2012, NASA strategically set up 17 RHTemp101A ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... -- Since its commercial introduction in 2005, ... science tool for conducting genetic studies in a range ... its new report that the industry sits on the ... a range of new applications in the clinical diagnostics ... ) , Since the Human Genome ...
(Date:5/25/2016)...  Zymo Research Corp. announced today the final ... that help researchers obtain the most accurate and ... rapid growth of the study of microbiomes has ... methods to improve the reproducibility and quality of ... every step of the measurement process including collection ...
(Date:5/25/2016)... , May 25, 2016 Digital ... issuance to it by the US Patent and ... company,s technology includes proprietary processes for electronic opt-­in ... health and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows ...
Breaking Medicine Technology: