Navigation Links
Low vitamin D levels do not increase the risk of chronic obstructive pulmonary disease
Date:11/3/2011

Vitamin D levels are not related to acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in patients with severe COPD, according to a large prospective cohort study involving 973 North American patients. The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

In the study, a secondary analysis of data from a randomized, controlled trial of the effects of azithromycin on the frequency of AECOPD, no relationship was found between baseline Vitamin D levels and time to first AECOPD or between vitamin D levels and AECOPD exacerbation rates.

"Vitamin D insufficiency and deficiency are common in patients with COPD, and patients with severe COPD are at the highest risk for exacerbations, so we hypothesized that low vitamin D levels might increase the risk of AECOPDs," said Ken M. Kunisaki, M.D., of the Minneapolis Veterans Affairs Medical Center. "Our negative results are in contrast with earlier studies in which lower vitamin D levels were associated withhigher rates of respiratory infections in adults and more frequent asthma exacerbations in children."

In the current study, mean forced expiratory volume in one second (FEV1) was 1.12L, 40% of predicted. Mean vitamin D level at baseline was 25.7 12.8 ng/mL, with 33.1% of subjects categorized as vitamin D insufficient (≥20 ng/mLbut <30 ng/mL), 32.0% as vitamin D deficient (<20 ng/mL) and 8.4% as having severe vitamin D deficiency (<10 ng/mL).AECOPDs were defined as a complex of respiratory symptoms (increased or new-onset) of at least 1 of thefollowing: cough, sputum, wheezing, dyspnea, or chest tightness with a durationof at least 3 days and requiring treatment with an antibiotic or systemiccorticosteroid.

During 1 year of follow-up, study subjects experienced a total of 1415 AECOPDs. Of 973 patients,360 (37%)remained AECOPD-free, 278 (29%) had 1 AECOPD, 133 (14%)had 2 AECOPDs, and 202 (21%) had 3 or moreAECOPDs.

In the primary analysis, vitamin D levels had no relationship to time to first AECOPD; for a 10 ng/mL increment in vitamin D level, the estimated hazard ratio was 1.04 (95% confidence interval: 0.97-1.12). In secondary analyses, vitamin D levels were not related to annualized rates of AECOPDs in either Poisson (p=0.82)or negative binomial analyses (p=0.87).

Patients with severe vitamin D deficiency had a higher mean rateof AECOPDs, but this difference was not statistically significant. Patients with severe vitamin D deficiency did not exhibit faster time to first AECOPD than other patients.

The study had some limitations. Vitamin D levels were only assessed at baseline, and so may have changed during the study period. Seasonal changes in vitamin D levels may also have occurred.

"Contrary to what we expected, baseline vitamin D levelswere not related to the risk of subsequent AECOPDs in this large group of COPD patients at high risk of AECOPD," Dr. Kunisaki said. "Vitamin D supplementation is unlikely to have an effect on AECOPD risk in these patients."


'/>"/>
Contact: Nathanial Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Caucasians who avoid sun exposure more likely to be vitamin D deficient, Stanford study suggests
2. Low vitamin D common in spine surgery patients
3. Vitamin B-based treatment for corneal disease may offer some patients a permanent solution
4. Women do not get enough vitamin D during the menopause
5. Research Sheds Light on Vitamin Ds Role in Immunity
6. Extra Vitamin E May Be Associated With Prostate Cancer
7. National study finds vitamin E supplement may increase prostate cancer risk
8. Oral steroids linked to severe vitamin D deficiency in nationwide study
9. Could Too Little Vitamin B-12 Shrink the Aging Brain?
10. Many Black Men in Cold Climates Lack Vitamin D
11. Vitamin D deficiency linked with airway changes in children with severe asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... ... A new collaboration will give more researchers access to the largest and oldest ... SAS will provide researchers worldwide with data management and analytics tools to explore 45 ... The DCRI and SAS share the goal of greater transparency and openness in research ...
(Date:5/4/2016)... TX (PRWEB) , ... May 04, 2016 , ... ... of a master charity program created to assist the people of their local ... closely with nonprofit organizations and community leaders. Their hope is to bring awareness ...
(Date:5/4/2016)... ... 04, 2016 , ... May kicked off with Melanoma Monday , a ... Dr. Ellen Turner is encouraging her patients, as well as residents all around Dallas, ... and health now and in the future. , The dermatology-specific awareness month ends with ...
(Date:5/4/2016)... ... May 04, 2016 , ... Dr. Elyson and Dr. Assili, dentist in ... office. Wisdom tooth removal, a common dental procedure, is performed for many adolescents and ... erupted, resulting in risks of complications. By providing wisdom tooth removal surgery at their ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... of foundational nutrients that supports cellular and metabolic health. This synergistic combination of ... mg free-form curcumin, along with 150 mg of reduced glutathione and 200 mg ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... KANSAS CITY, Mo. , May 3, 2016 ... of Kansas Medical Center,s Institute for Advancing Medical ... develop and commercialize new drugs, diagnostics and medical ... organizations provides BioNovus Innovations with rights to license, ... "This partnership ...
(Date:5/3/2016)... -- As a teenager, an active and athletic Randy ... heart. He continued enjoying sports and recreation throughout his ... was giving out and he was a few hours ... Mesa, Arizona resident received a ... transplant, the SynCardia TAH-t is the only approved device ...
(Date:5/3/2016)...  While you may be familiar with watching a film or TV show in high definition, ... 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller of the medical industry,s ... - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
Breaking Medicine Technology: