Navigation Links
Low steroid levels linked to increased risk of cardiovascular disease

Low levels of a naturally occurring steroid are associated with an increased risk of heart and blood-vessel disease in elderly men, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

The steroid in question is dehydroepiandrosterone, or DHEA, which is secreted by the adrenal gland and circulates in blood mainly in a sulfated form, DHEA-S. In other tissues, DHEA-S is converted into the sex hormones testosterone and estrogen.

Previous, smaller studies found an association between low DHEA-S levels and heart and blood-vessel, or cardiovascular, disease, although their results were inconclusive. At this time, while we know that DHEA production decreases with age, the exact health effects of its decline are unclear.

In this large-scale study, investigators study found that elderly men with the lowest DHEA-S blood levels were significantly more likely than those with higher concentrations to develop cardiovascular-disease events within five years. The increased risk persisted even after controlling for other influences, indicating that low DHEA-S levels are independently associated with a greater risk of disease.

"Our findings may be the result of DHEA-S being protective, or that lower DHEA-S level is a marker for poor general health," said study lead author sa Tivesten, M.D., Ph.D., associate professor at the University of Gothenburg, Sweden. "More research is needed to understand underlying mechanisms and to evaluate the potential benefits of hormone replacement."

Investigators used an advanced laboratory technique to isolate, identify, and measure DHEA-S levels in the blood. During the five-year follow-up, they used nationwide medical registries to document 485 cases of cardiovascular disease among the study participants.

Patients included 2,416 men between the ages of 69 and 81 years. All were participants in the Osteoporotic Fractures in Men Sweden study, which is a long-term project designed to examine risk factors for a number of diseases.

According to Tivesten, it is important to note that this study's findings only indicate that low DHEA-S levels may be related to a greater risk of cardiovascular disease. "We cannot say that DHEA-S is protective because we have only studied an association," she said.

"A potential practical implication is that established cardiovascular risk factors perhaps should be assessed and treated more aggressively in men with lower DHEA-S levels. However, this must be evaluated in future studies; today, DHEA-S level is not part of cardiovascular-risk assessment."


Contact: Aaron Lohr
The Endocrine Society

Related medicine news :

1. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
2. Identifying asthma patients who tolerate lower doses of steroids remains problematic
3. Steroid Nasal Sprays Show Small Benefit for Sinusitis: Study
4. Inhaled Steroids Lead to Big Drop in Asthma Deaths at Texas Hospital: Study
5. Gatekeeper of brain steroid signals boosts emotional resilience to stress
6. Declining testosterone levels in men not part of normal aging, study finds
7. EPA Proposes New Cuts on Levels of Soot in Air
8. New device warns workers of high levels of airborne metals in minutes rather than weeks
9. Aggressively controlling glucose levels may not reduce kidney failure in Type 2 diabetes
10. Revised ARDS definition sets out levels of severity
11. Dieting May Lower Hormone Levels Tied to Breast Cancer
Post Your Comments:
(Date:10/13/2017)... ... 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud ... and unique items from across the nation, this holiday-themed event will raise funds and ... the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a ... has been awarded a contract by the Center for Medicare and Medicaid Services ... accelerate the enterprise use of Agile methodologies in a consistent and high value ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... ... 2017 , ... Information about the technology: , Otomagnetics has ... prevention of a major side effect of chemotherapy in children. Cisplatin and carboplatin ... cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. Hearing ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... named one of Michigan’s 2017 Best and Brightest in Wellness® by Best and ... Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
Breaking Medicine Technology: