Navigation Links
Low levels of pro-inflammatory agent help cognition in rats
Date:1/28/2014

SAN ANTONIO (Jan. 28, 2014) Although inflammation is frequently a cause of disease in the body, research from The University of Texas Health Science Center at San Antonio indicates that low levels of a pro-inflammatory cytokine in the brain are important for cognition. Cytokines are proteins produced by the immune system.

Jennifer Donegan, graduate student, and David Morilak, Ph.D., professor of pharmacology in the School of Medicine, found that neutralizing the cytokine interleukin-6 in the brain impaired reversal learning in both stressed and nonstressed rats. Reversal learning is a form of cognitive flexibility that is diminished in psychiatric diseases such as depression, schizophrenia and post-traumatic stress disorder. Cognitive flexibility is the ability to change previously learned thoughts and behaviors in response to changes in the environment.

"When we started the project, we thought cognitive flexibility would be impaired by stress-induced inflammation in a region of the brain called the prefrontal cortex," Donegan said. "We decided to block interleukin-6 during stress to prevent the cognitive deficit, and to our surprise this made things worse. This suggested that it may actually be beneficial to maintain a low level of this pro-inflammatory cytokine in the brain."

Low level corrected deficit

As a key next step, the scientists were then able to fix the cognitive deficit caused by stress by restoring a low level of the cytokine specifically in the prefrontal cortex. Both scientists caution, however, that there is still much to learn about interleukin-6's role in cognition and in diseases like depression. "We've replicated just one piece of a very complex disease so we can understand the biology," Dr. Morilak said. "We found that, in one brain region, one cytokine facilitates cognitive flexibility and is beneficial after chronic stress. But we delivered the cytokine specifically into that brain region using a virus, which we cannot do in people. And its role in inflammation may be very different than in normal conditions. There's still a lot of work to do."

Donegan is on track to receive her Ph.D. later this year. She is lead author and Dr. Morilak is senior author of the study, published this month in the Journal of Neuroscience. The research is funded by the National Institute of Mental Health and the Brain & Behavior Research Foundation.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related medicine news :

1. GameStop Levels Up To Cherwell Service Management
2. RF Safe List of Lowest Radiation Cell Phones by Specific Absorption Rate (SAR) Levels
3. How to Increase Testosterone Levels Naturally Discussed in New Video by Diet Recommendations
4. In Light of Increased Levels of Personal Stress Over the Holiday Season, Lanahan Insurance Recommends Staying Covered with Health Insurance
5. A New “15 Blood Sugar Control Tips” Article Teaches People How To Control Their Blood Sugar Levels Naturally – V-kool
6. A New “11 Ways To Increase Testosterone” Article Helps Men Boost Testosterone Levels Naturally – V-kool
7. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
8. Diet Doc Hormone Diets & Weight Loss Plans Introduce Weight Loss Supplements Containing Prescription Hormone Levels to Increase the Effectiveness of Paleo Diets
9. “Crunch Cholesterol” Teaches People How To Reduce High Cholesterol Levels Quickly And Easily – Vkoolelite
10. Study reveals higher levels of control and support at work increases wellbeing
11. Oxygen levels in tumors affect response to treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... MA (PRWEB) , ... August 17, 2017 , ... ... will come together on September 19, 2017 for Anti-Infectives Rx. This off-the-record networking ... B. Martin Conference Center at Harvard Medical School. , Industry leaders and decision ...
(Date:8/17/2017)... City, Utah (PRWEB) , ... August 17, 2017 , ... ... share how to efficiently and effectively grow a dental practice in a competitive market ... hours of dental C.E. that could just transform you and your practice.” says Daniel ...
(Date:8/17/2017)... ... August 17, 2017 , ... The 2017 ... and healthcare systems to interact with their GPO and supplier partners. This year, ... BCN, CVAHP, System Director of Clinical Value Analytics, have been invited to present ...
(Date:8/17/2017)... ... August 17, 2017 , ... Aeroflow Healthcare today announced ... America’s fastest growing private companies. Inc. magazine ranked Aeroflow Healthcare #2450 on its ... , The Inc. 5000 represents the most comprehensive study of American entrepreneurial ...
(Date:8/17/2017)... Prairie, Minnesota (PRWEB) , ... August 17, 2017 , ... ... business publication has ranked the multichannel growth agency among the fastest-growing private companies in ... the tens of thousands of companies that have applied to the Inc. 5000 ...
Breaking Medicine News(10 mins):
(Date:7/31/2017)... FLINT, Mich. , July 31, 2017  Diplomat Pharmacy, ... companies in southeast Michigan by ... feature ranks private and public companies by three-year revenue growth. ... To view the complete list, ... Crain,s Fast 50 is an incredible triumph," said Phil ...
(Date:7/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: ... quarter ended June 30, 2017, and updated its financial ... For the fiscal third quarter, Hill-Rom reported ... per diluted share in the prior-year period. These results ... per diluted share primarily related to the non-cash write-down ...
(Date:7/27/2017)... July 27, 2017  West Pharmaceutical Services, Inc. (NYSE: ... for the second-quarter 2017 and updated financial guidance for ... Second-Quarter 2017 Highlights Reported net sales ... the prior-year quarter. Net sales at constant currency (organic) ... EPS was $0.51, compared to $0.60 in the prior-year ...
Breaking Medicine Technology: