Navigation Links
Low levels of pro-inflammatory agent help cognition in rats
Date:1/28/2014

SAN ANTONIO (Jan. 28, 2014) Although inflammation is frequently a cause of disease in the body, research from The University of Texas Health Science Center at San Antonio indicates that low levels of a pro-inflammatory cytokine in the brain are important for cognition. Cytokines are proteins produced by the immune system.

Jennifer Donegan, graduate student, and David Morilak, Ph.D., professor of pharmacology in the School of Medicine, found that neutralizing the cytokine interleukin-6 in the brain impaired reversal learning in both stressed and nonstressed rats. Reversal learning is a form of cognitive flexibility that is diminished in psychiatric diseases such as depression, schizophrenia and post-traumatic stress disorder. Cognitive flexibility is the ability to change previously learned thoughts and behaviors in response to changes in the environment.

"When we started the project, we thought cognitive flexibility would be impaired by stress-induced inflammation in a region of the brain called the prefrontal cortex," Donegan said. "We decided to block interleukin-6 during stress to prevent the cognitive deficit, and to our surprise this made things worse. This suggested that it may actually be beneficial to maintain a low level of this pro-inflammatory cytokine in the brain."

Low level corrected deficit

As a key next step, the scientists were then able to fix the cognitive deficit caused by stress by restoring a low level of the cytokine specifically in the prefrontal cortex. Both scientists caution, however, that there is still much to learn about interleukin-6's role in cognition and in diseases like depression. "We've replicated just one piece of a very complex disease so we can understand the biology," Dr. Morilak said. "We found that, in one brain region, one cytokine facilitates cognitive flexibility and is beneficial after chronic stress. But we delivered the cytokine specifically into that brain region usi
'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1 2

Related medicine news :

1. GameStop Levels Up To Cherwell Service Management
2. RF Safe List of Lowest Radiation Cell Phones by Specific Absorption Rate (SAR) Levels
3. How to Increase Testosterone Levels Naturally Discussed in New Video by Diet Recommendations
4. In Light of Increased Levels of Personal Stress Over the Holiday Season, Lanahan Insurance Recommends Staying Covered with Health Insurance
5. A New “15 Blood Sugar Control Tips” Article Teaches People How To Control Their Blood Sugar Levels Naturally – V-kool
6. A New “11 Ways To Increase Testosterone” Article Helps Men Boost Testosterone Levels Naturally – V-kool
7. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
8. Diet Doc Hormone Diets & Weight Loss Plans Introduce Weight Loss Supplements Containing Prescription Hormone Levels to Increase the Effectiveness of Paleo Diets
9. “Crunch Cholesterol” Teaches People How To Reduce High Cholesterol Levels Quickly And Easily – Vkoolelite
10. Study reveals higher levels of control and support at work increases wellbeing
11. Oxygen levels in tumors affect response to treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... July 24, 2014 (HealthDay News) -- Women who compete ... disorders, including incontinence, and other health problems, a new ... popularity of high-impact sports such as triathlons, but little ... pelvic health and certain other issues associated with endurance ... physiatrist at Loyola University Health System, said in a ...
(Date:7/25/2014)... initial romantic encounters determine the fate of a potential ... necessary to fuel sexual desire and land a second ... for both men and women on a first date. ... Do men perceive responsive women as more attractive, and ... men? A study published in Personality and Social ...
(Date:7/25/2014)... 25, 2014 The Futon Shop ... Futon Sale. The Futon Shop has been around since 1976 ... has grown from a few handmade futon mattresses a month, ... of futon mattresses. , The Futon Shop futon mattresses ... the desire to sleep on natural fibers was a growing ...
(Date:7/25/2014)... July 25, 2014 Stwd.co.uk, one of ... new collection of cheap evening dress for ... launch a big promotion for these items. They are ... promotion will last until August 30. , “We are ... Beside evening outfits, we have a large number of ...
(Date:7/25/2014)... Mirada (PRWEB) July 25, 2014 ... La Mirada clinic is offering Occupational Medicine ... Center is happily accepting referrals and workers’ compensation ... the La Mirada clinic include wound care treatment ... and ergonomic assessments, pre-employment screening & physicals, and ...
Breaking Medicine News(10 mins):Health News:Female Triathletes May Face Health Problems Such as Incontinence 2Health News:Why do men prefer nice women? 2Health News:Why do men prefer nice women? 3Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 2Health News:Organic Mattress Manufacturer Celebrates 38 Years Of Being In Business 3Health News:Famous Supplier Stwd.co.uk Announces Its New Selection of Evening Dresses for Women 2Health News:Healthpointe Offering Occupational Medicine Services in La Mirada 2
... of deep concern and disappointment about reports that the ... issues that are critical to access to care for ... the American College of Physicians (ACP). David C. ... behalf of the 124,000 internal medicine physicians and medical ...
... Supplier, WAKEFIELD, Mass., Sept. 21 Friends ... research and programs,today announced that it is recalling ... to donors who contribute to its cancer-related programs. ... supplier that the,bracelets did not contain lead. When ...
... and treatments to save dogs,from cancer and the benefits ... subject of a news report that debuted on ABC ... picked up by about 15,stations nationwide, detailed the innovative ... the University of California-Davis and,being funded and supported by ...
... is a,statement by Robert Greenstein, executive director of ... new congressional SCHIP agreement:, "Today,s agreement would ... a major accomplishment. Contrary to White,House rhetoric, the ... are poor,and near-poor children who are uninsured, not ...
... patients with incurable disease fared better, doctor says , FRIDAY, ... tumors may help improve treatment for some patients with incurable ... president of Oncology Care Associates in St. Joseph, Mich., had ... drugs might offer them the most benefit, Lester used DNA ...
... 20 -- A new study led by investigators from the ... of necrosis, long thought to be a chaotic, irreversible pathway ... a regulated response to stress by a powerful protein, SRP-6, ... research team realized that this protein might be harnessed to ...
Cached Medicine News:Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 2Health News:'Deep concern and disappointment' with exclusion of Medicare from SCHIP legislation 3Health News:Friends of Mel Announce Recall of Jewelry Due to Lead 2Health News:Friends of Mel Announce Recall of Jewelry Due to Lead 3Health News:ABC TV San Francisco Features Canine Cancer Research Story: Saving Our Dogs, Helping Humans Beat Cancer - Work at Morris Animal Foundation, UC-Davis 2Health News:Statement by Robert Greenstein, Executive Director of the Center on Budget and Policy Priorities, on the New Congressional SCHIP Agreement 2Health News:Pathway to cell death redefined in landmark study 2Health News:Pathway to cell death redefined in landmark study 3Health News:Pathway to cell death redefined in landmark study 4
(Date:7/25/2014)... /PRNewswire-iReach/ -- Dr. Michael Gabriel of a prominent ... a recent study, which shows how grief in pregnancy may ... According to US News , ... likely than others to grow up overweight or obese, even ... were two specific types of stress that caused obesity: "Children ...
(Date:7/24/2014)... 24, 2014  Parnell Pharmaceuticals Holdings Ltd announces ... be added to Parnell,s already extensive pipeline through ... a biotechnology company. The compounds now known as ... in bone regeneration and dermal regeneration, respectively. Parnell ... for the veterinary market with the potential to ...
(Date:7/24/2014)... Wis. , July 24, 2014  Restore ... specialty and compounded pharmaceuticals, announced that it is ... information unique to each individual based upon their ... possible by understanding the interaction between a patient,s ... "We,re very excited to provide this new ...
Breaking Medicine Technology:Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 2Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 3Parnell Acquires License for Intellectual Property and Rights to Develop Compounds for Bone and Dermal Regeneration 4Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 2Restore Health Launches Pharmacogenetic Testing, Enhancing Its Suite of Personalized Medicine Goods and Services 3
... Neuralstem, Inc. (NYSE Amex: CUR ) updated the ... the company,s spinal cord stem cells in the treatment of ... University in Atlanta, Georgia. The company announced that, after reviewing the ... Monitoring Board has unanimously approved moving to the last group ...
... Science Corporation , a global leader in automated external defibrillator ... has been awarded a contract to deploy Powerheart® AEDs at ... Postal Inspection Service is the primary law enforcement arm of ... to have been selected to protect the men and women ...
Cached Medicine Technology:Neuralstem Updates ALS Clinical Trial Progress 2Neuralstem Updates ALS Clinical Trial Progress 3Neuralstem Updates ALS Clinical Trial Progress 4U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 2U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 3U.S. Postal Inspection Service Awards AED Contract to Cardiac Science 4
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... chairs are recommended for the following ... static control, health care and office. ...
... Basic ergonomic chairs with concave ... support • Select options like seats, ... are recommended for the following environments: ... control, health care and office. • ...
... Basic ergonomic chairs with ... with lumbar support • Select ... and casters and glides. • ... the following environments: industry, education, ...
Medicine Products: