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Low doses of arsenic cause cancer in male mice
Date:7/8/2014

Mice exposed to low doses of arsenic in drinking water, similar to what some people might consume, developed lung cancer, researchers at the National Institutes of Health have found.

Arsenic levels in public drinking water cannot exceed 10 parts per billion (ppb), which is the standard set by the U.S. Environmental Protection Agency. However, there are no established standards for private wells, from which millions of people get their drinking water.

In this study, the concentrations given to the mice in their drinking water were 50 parts per billion (ppb), 500 ppb, and 5,000 ppb. 50 ppb is the lowest concentration that has been tested in an animal study, and researchers say that because of differing rates of metabolism, mice need to be exposed to greater concentrations of arsenic in drinking water than humans to achieve the same biological dose and similar health effects.

The researchers used a model that duplicates how humans are exposed to arsenic throughout their entire lifetime. In the study, the mice were given arsenic three weeks before breeding and throughout pregnancy and lactation. Arsenic was then given to the offspring after weaning, and all through adulthood at concentrations relevant to human exposure. The researchers looked at the tumors in the adult offspring.

"This is the first study to show tumor development in animals exposed to very low levels of arsenic, levels similar to which humans might be exposed," said Michael Waalkes, Ph.D., lead author on the paper and director of the National Toxicology Program (NTP) Laboratory. "The results are unexpected and certainly give cause for concern."

Arsenic is present in the environment as a naturally occurring substance or due to contamination from human activity. Arsenic may be found in many foods, including grains, fruits, and vegetables, where it is present due to absorption from the soil and water. This study focused on inorganic arsenic, which o
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Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert  

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