Navigation Links
Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
Date:5/1/2012

Low dose whole body CT is nearly four times better than radiographic skeletal survey, the standard of care in the U.S., for determining the extent of disease in patients with multiple myeloma, a new study shows.

The study, conducted at the University of Maryland in Baltimore, included 51 patients who had both a radiographic skeletal survey as well as a low dose whole body CT examination. The total number of lesions detected in these patients with low dose whole body CT was 968 versus 248 detected by radiographic skeletal survey, said Kelechi Princewill, MD, the lead author of the study. "The stage of disease determines treatment, and the study found that in 31 patients, the stage of disease would have been different with low dose whole body CT. Thirteen patients would have been upstaged from stage I to stage II; nine patients would have been upstaged from stage I to stage III and nine patients would have been upstaged from stage II to III based on additional lesions detected on the low dose whole body CT," said Dr. Princewill.

Low dose whole body CT was significantly better than radiographic skeletal survey in detecting lesions in the spine, ribs, sternum and flat bones, added Dr. Princewill.

The use of low dose whole body CT is accepted in Europe as an accurate alternative to radiographic skeletal survey for detecting bone lesions in these patients, said Dr. Princewill. A concern about radiation dose may be one of the reasons why it is not widely accepted in the U.S., he said. "Our study employed a low dose protocol, with an average recorded CT dose of 4.1 mSv. That compares to 1.8 mSv for the radiographic skeletal survey. Using modified protocols and exposure parameters, we were able to significantly reduce the radiation doses to our patients without significantly compromising the image quality required to detect myeloma lesions. The average CT dose used in our study was approximately nine times lower than doses used in the acquisition of standard body CT studies," Dr. Princewill said.

The study is being presented on May 2 at the American Roentgen Ray Society annual meeting in Vancouver, Canada.


'/>"/>

Contact: Samantha Schmidt
sschmidt@arrs.org
703-858-4316
American Roentgen Ray Society
Source:Eurekalert

Related medicine news :

1. Low-Dose Aspirin to Prevent First Heart Attack or Stroke? Not So Fast
2. Low-Dose Aspirin After Lung Clot Could Prevent Recurrence
3. Even low-dose aspirin may increase risk of GI bleeding
4. Screening with low-dose spiral CT scanning reduces lung cancer deaths by 20 percent
5. New Blood Thinner Beats Plavix When Paired With Low-Dose Aspirin
6. Low-dose sorafenib may improve therapy for head and neck cancer
7. Low-dose chest CT effective in reducing radiation for evaluation of cardiothoracic surgery patients
8. Risk of cancer increases with exposure to low-dose radiation
9. Small bowel blood flow in healthy subjects receiving low-dose aspirin
10. Low-Dose Aspirin Boosts Accuracy of Colon Cancer Test
11. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... ... The Hong Kong Polytechnic University (PolyU) launched today the University Research Facility ... Hong Kong to support teaching, learning and research. It is also the largest research ... Hong Kong. , With an area of 620 square metres and more than ...
(Date:4/21/2017)... ... 21, 2017 , ... Airway Management, the medical device manufacturer ... regarded and well renowned Asian distributor, Discovery Sleep. The agreement involves ... Mask, and will stabilize and strengthen Airway’s presence with a dedicated, reputable medical ...
(Date:4/21/2017)... CA (PRWEB) , ... April 21, 2017 , ... Providing ... not understand the estate planning process, or where to even begin. “Now more than ... if you are to properly protect yourself and your family,” said attorney Lisa Edgar ...
(Date:4/21/2017)... , ... April 21, 2017 , ... Each year, everyone ... a day to clean, plant trees and look forward to a better future. However, ... about doing something outdoors. Indoor air quality can be two to five times more ...
(Date:4/21/2017)... ... April 21, 2017 , ... Indiana ... significant bandwidth upgrade infrastructure service to Tele-Media Solutions. IFN is delivering Multi-Gigabit ... IFN’s consortium member-owners, Tele-Media Solution’s protect transport with 3GB Dual Access Internet access ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... Mass. , April 20, 2017  RXi ... developing innovative therapeutics that address significant unmet medical ... data from the Company,s consumer product development program, ... at the Society for Investigative Dermatology (SID) 76 ... to advance and promote the sciences relevant to ...
(Date:4/20/2017)... 20, 2017  AbbVie (NYSE: ABBV), a global ... of chronic hepatitis C virus (HCV) infected patients ... and compensated cirrhosis (Child-Pugh A) achieved sustained virologic ... with its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). ... following 12 weeks of G/P treatment without ribavirin. ...
(Date:4/20/2017)... -- Research and Markets has announced the addition ... Analysis By Service (Manufacturing, Research), By Country, (Brazil, Mexico, Colombia, ... report to their offering. ... The Latin American pharmaceutical contract manufacturing services market is ... Low drug registration cost in Latin American countries and continuous ...
Breaking Medicine Technology: